GATA1
-
Official Full Name
GATA binding protein 1 (globin transcription factor 1)
-
Overview
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] -
Synonyms
GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GATA1 Related Articles
GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| C-MYB transcription factor network | MYB;TOM1;CEBPA;MYOD1;YEATS4;PTCRA;CSF1R;GATA1;CLTA |
| Factors involved in megakaryocyte development and platelet production | GATA2;KIF4A;KLC3;MAFF;BA2;OSTN;DOCK1;ITPK1;MAFGB |
| Hemostasis | BSG;BA1L;STXBP3A;JAM2B;CXADR;PDE10A;TREM1;MFN1;LRRC16A |
| IL-3 Signaling Pathway | GNB2L1;GATA1A;BMX;SPI1B;GATA2A;BIRC5A;GATA1;PILRB;CISH |
| Notch-mediated HES/HEY network | MYOD1;HES6;GATA1;TLE1;BGLAP;ASCL1;GATA6;CTBP1;HEY1 |
| Signaling events mediated by HDAC Class I | NR2C1;MXD1;SIRT4;SIRT2;WDR77;TFCP2;GATA1;SIRT7;SIRT5 |
| Signaling events mediated by HDAC Class II | GATA1;BCOR;ANKRA2 |
GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C2H2 zinc finger domain binding | GATA2;ZXDC;TAF9;EHMT1;EHMT2;U2AF2;WT1;GATA1;THAP7 |
| DNA binding | LHX1A;MSGN1;TMPO;POLR2K;NKX1.2LB;AHCTF1;PSMC3IP;HINFP;ATOH7 |
| DNA binding, bending | TOP2B;GATA1;LEF1;TERF1;HMGA2;TFAM;HMGB3;HMGB1;FOXI1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ASCL2;SOX10;NR1D1;SREBF1;ZNF264;NR2C1;FOXJ1;MAFA;SMAD3 |
| RNA polymerase II core promoter sequence-specific DNA binding | TAL1;SFPI1;TRP53;GBX2;H2AFZ;ZFP335;NFIL3;GATA6;SMYD3 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF792;SATB1;ZFP39;ZNF583;GATA2;BARHL1B;ZNF561;XBP1;FOXD3 |
| RNA polymerase II transcription factor binding | MKX;DHX9;ATF4;CHST13;KDM1A;XBP1;ANKRD1;WWP2;GFI1B |
| chromatin DNA binding | HDAC3;THRB;WBP2;GRHL3;FOXC2;EZH2;H1F0;INSM1A;PPARGC1A |
| core promoter binding | HDAC2;XBP1;RB1;E2F8;DHX36;FOXP3;KDM3A;E2F7;INSM1B |
| enhancer sequence-specific DNA binding | LMO4;FOXN4;MYT1;SOX9;GATA1;XBP1;TFAP2B;GATA4;ATF2 |
| p53 binding | EP300;GATA1;RNF34;BCL2L12;CDK5;CREBBP;SMYD2;TP53RK;GSK3B |
| protein binding | KLF2;PARD6B;NDP;ID1;PTTG1IP;FAM49B;RGS7BP;MXD1;TRIM67 |
| sequence-specific DNA binding | MAFK;BCL11AB;PRRXL1;ZNF397;HSF4;PRDM16;PPARA;HSFX1;BARHL1A |
| transcription factor activity, sequence-specific DNA binding | SP3A;FOXP3;YY1;ZNF573;STAT5B;ZNF256;UHRF1;PLAGL2;NR5A1A |
| transcription regulatory region sequence-specific DNA binding | NONO;SUV39H1;BTBD8;NKX3;NFE2L2B;NFE2;SOX2;POU5F1;NR5A5 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PITX1;NR4A2;ALS2CR8;SIX2;NFKB2;RFX4;HOXA5;SOX12;NR1H2 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | PAX9;FEZF2;PKNOX1;ZGLP1;SLAMF7;GATA1;HIF1A;ALX4;MAF |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZFP90;NKX6-1;ASCL2;ZKSCAN3;EN1;GFI1;HES1;NFATC2;BCL11AB |
| zinc ion binding | ESRRGB;MAN2A2;ZDHHC4;CAD;TRIM16;TRIM43C;CSRP3;POLR2L;BPTF |
GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.
FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL
- Q&As
- Reviews
Q&As (5)
Ask a questionGATA1 primarily functions in hematopoiesis and is not directly involved in the regulation of immune responses. Its role is more specific to blood cell development.
Yes, mutations in the GATA1 gene are linked to various hematological disorders, including Diamond-Blackfan anemia and transient myeloproliferative disorder in Down syndrome.
Knowledge of GATA1 mutations can contribute to a more accurate prognosis, guiding healthcare professionals in developing appropriate treatment plans and monitoring strategies.
Yes, mutations in the GATA1 gene have been implicated in the development of acute megakaryoblastic leukemia, particularly in children with Down syndrome.
GATA1 controls the expression of genes necessary for normal blood cell development, ensuring proper function and regulation of erythrocytes and platelets.
Customer Reviews (3)
Write a reviewWhether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
In addition to its scientific merits, the manufacturer of GATA1 protein stands out for its outstanding technical support.
Ask a Question for All GATA1 Products
Required fields are marked with *
My Review for All GATA1 Products
Required fields are marked with *
