GBA
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Official Full Name
glucosidase, beta, acid
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Overview
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. -
Synonyms
GBA; glucosidase, beta, acid; GLUC, glucosidase, beta; acid (includes glucosylceramidase) , glucosylceramidase; glucosylceramidase; GBA1; alglucerase; imiglucerase; acid beta-glucosidase; beta-glucocerebrosidase; lysosomal glucocerebrosidase; D-glucosyl;
- Recombinant Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- GBA Related Articles
- GBA Related Research Area
GBA involved in several pathways and played different roles in them. We selected most pathways GBA participated on our site, such as Other glycan degradation, Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | ENG-1;NEU3;HEXDC;NEU3.4;GBA;MANBA;NEU4;NEU3.5;NEU3.3 |
| Sphingolipid metabolism | GALCB;LASS2;UGCG;SPHK2;GLA;ASAH1A;GDF1;SMPD2A;ARSA |
| Metabolic pathways | GALNT11;ADH4;TPI1B;NDUFS8A;PLA2G5;PLD1;ALG14;ATP6V1G2;ALG10B |
| Lysosome | CTSSB.2;GALCB;GBA;GLB1;MANBA;NAPSA;GNPTAB;CTSC;GALC |
GBA has several biochemical functions, for example, glucosylceramidase activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA itself. We selected most functions GBA had, and list some proteins which have the same functions with GBA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucosylceramidase activity | GBA;GBA2 |
| protein binding | TIMM44;CDK17;C1QTNF1;MYLK2;C1S;CTU2;RNF20;RBM6;STX4A |
| receptor binding | CD58;Itga10&Itgb1;LRRC4B;PTPRD;Artn;CRAT;BMP2;TIGIT;EFNA1 |
GBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA.
Scarb2; pi3p; SCAMP3; TOP3B; A2M; cona_canen; HSPD1; HSP90B1; ATP5J; CANX; ATP6V1A; SKIV2L2; CCT3; CCT8; RPS6KA3; FMR1; ZMYND11; DHCR24; RNF20; ZCCHC8
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Customer Reviews (3)
Write a reviewThis guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.
They ensure the purity, integrity, and functionality of GBA protein through rigorous quality control measures.
The manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes
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