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GCA

  • Official Full Name

    grancalcin, EF-hand calcium binding protein

  • Overview

    This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
  • Synonyms

    GCA; grancalcin, EF-hand calcium binding protein; grancalcin, EF hand calcium binding protein; grancalcin; GCL; OTTHUMP00000162937; OTTHUMP00000204639; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GCA-2921H Recombinant Human GCA grancalcin, EF-hand Calcium Binding Protein, His-tagged E.coli His
Human GCA-4382H Recombinant Human Grancalcin, EF-hand Calcium Binding Protein, His-tagged Human His
Human GCA-26242TH Recombinant Human GCA, His-tagged E.coli His 217 amino acids
Human GCA-6941H Recombinant Human GCA, His tagged E.coli His
Human GCA-6903H Recombinant Human Grancalcin, EF-hand Calcium Binding Protein, His-tagged E.coli His 1-217aa
Human GCA-5994HCL Recombinant Human GCA 293 Cell Lysate HEK293 N/A
Human GCA-3762H Recombinant Human GCA protein, GST-tagged E.coli GST 1-217 aa
Human GCA-1316H Recombinant Human GCA Protein E.coli N/A
Human GCA-4787H Recombinant Human GCA Protein, GST-tagged Wheat Germ GST
Human GCA-4911H Recombinant Human GCA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GCA-2H Native Human Gastrointestinal Cancer Antigen N/A
Human GCA-5164HF Recombinant Full Length Human GCA Protein, GST-tagged In Vitro Cell Free System GST 217 amino acids
Human GCA-3475H Recombinant Human GCA Protein (Met1-Val139), N-His tagged E.coli N-His Met1-Val139
Mouse Gca-7825M Recombinant Mouse Gca protein, His & T7-tagged E.coli His/T7 Gly39~Ile220 (Accession # Q8VC88)
Mouse Gca-3170M Recombinant Mouse Gca Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque GCA-1819R Recombinant Rhesus monkey GCA Protein, His-tagged Mammalian Cell His
Rhesus Macaque GCA-1640R-B Recombinant Rhesus Macaque GCA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GCA-1640R Recombinant Rhesus Macaque GCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GCA Related Articles
  • GCA Related Research Area

GCA involved in several pathways and played different roles in them. We selected most pathways GCA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

GCA has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCA itself. We selected most functions GCA had, and list some proteins which have the same functions with GCA. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingANXA1;PLCZ1;CALM1;LDLRB;EHD3;FSTL1A;PCDHGB6;SYT16;PCDH2G3
calcium-dependent cysteine-type endopeptidase activityCAPN1;CAPN5;CAPN2B;PDCD6;CAPN2L;CAPNS1;CAPN3;CAPN3A;CAPN3B
protein bindingFAM114A1;HSPD1;TNIK;C14orf118;LNX2B;NADK;YTHDF3;EVC2;TTC1
protein heterodimerization activityCHRNB2;ANO9A;ZFP423;MYH7;SDCBP2;H2AFB3;SOX8;BMP7A;IKZF2
protein homodimerization activityPTS;BAXB;CDSN;GRIK1;PRDX4;FAP;TG;NRF1;TFAP4

GCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCA here. Most of them are supplied by our site. Hope this information will be useful for your research of GCA.

MAGEA8; EIF3H; ATXN1; EBNA2; RBFOX1

Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
Katsuyama, T; Sada, KE; et al. Current Concept and Epidemiology of Systemic Vasculitides. ALLERGOLOGY INTERNATIONAL 63:505-513(2014).
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Customer Reviews (3)

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Reviews
08/31/2020

    In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

    06/26/2019

      Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the GCA protein in my studies.

      09/12/2018

        The GCA protein comes highly recommended for its outstanding performance in various experimental applications.

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