gcdh
Share
  • Official Full Name
  • glutaryl-CoA dehydrogenase
  • Background
  • The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • GCDH; glutaryl-CoA dehydrogenase; glutaryl Coenzyme A dehydrogenase; glutaryl-CoA dehydrogenase, mitochondrial; ACAD5; mitochondrial; EC 1.3.99.7; GCD; GCDH_HUMAN; Glutaryl CoA dehydrogenase, mitochondrial; MS781; glutaryl-Coenzyme A dehydrogenase
Cat.#:Gcdh-8166MTag:His & T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gcdh protein, His & T7-tagged
+Inquiry
Cat.#:GCDH-2728HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutaryl-CoA Dehydrogenase, His-tagged
+Inquiry
Cat.#:GCDH-27464THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GCDH, His-tagged
+Inquiry
Cat.#:GCDH-6259MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GCDH Protein
+Inquiry
Cat.#:GCDH-539CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GCDH Protein, His-tagged
+Inquiry
Cat.#:GCDH-5992HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GCDH 293 Cell Lysate
+Inquiry

GCDH Related Articles

Gerstner, B; Gratopp, A; et al. Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: A novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency. PEDIATRIC RESEARCH 57:771-776(2005).
Kolker, S; Ahlemeyer, B; et al. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. PEDIATRIC RESEARCH 47:495-503(2000).
Kolker, S; Ahlemeyer, B; et al. Cerebral organic acid disorders induce neuronal damage via excitotoxic organic acids in vitro. AMINO ACIDS 18:31-40(2000).
KLEES, AG; LINDER, D; et al. 2-HYDROXYGLUTARYL-COA DEHYDRATASE FROM FUSOBACTERIUM-NUCLEATUM (SUBSP NUCLEATUM) - AN IRON-SULFUR FLAVOPROTEIN. ARCHIVES OF MICROBIOLOGY 158:294-301(1992).