GCLM
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Official Full Name
glutamate-cysteine ligase, modifier subunit
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Overview
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. -
Synonyms
GCLM; glutamate-cysteine ligase, modifier subunit; GLCLR; glutamate--cysteine ligase regulatory subunit; gamma glutamylcysteine synthetase; Gamma ECS regulatory subunit; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; Glutamate cysteine ligase regulatory subunit; Glutamate--cysteine ligase modifier subunit; GSH0_HUMAN; GSC light chain; OTTHUMP00000012299; glutamate-cysteine ligase regulatory protein; gamma-glutamylcysteine synthetase regula;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
GCLM involved in several pathways and played different roles in them. We selected most pathways GCLM participated on our site, such as Cysteine and methionine metabolism, Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCLM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | GOT2A;GCLC;GOT2;DNMT3A;BHMT;MTAP;BCAT2;SMS;TST |
| Glutathione metabolism | GSTAL;GGT1A;GGT5;RRM2B;GCLC;GSTT2B;RRM2;GSTT2;OPLAH |
| Metabolic pathways | COX6B2;AMY2A2;CYP19A1B;GCNT3;NDUFA1;MAT1A;CYP11B1;CYP26A1;AGK |
GCLM has several biochemical functions, for example, enzyme regulator activity, contributes_to glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCLM itself. We selected most functions GCLM had, and list some proteins which have the same functions with GCLM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme regulator activity | DCP1B;RAB3GAP2;EIF2B1;BRCC3;DPM2;PPP1R7;RGN;APOC3;MTMR9 |
| contributes_to glutamate-cysteine ligase activity | |
| glutamate-cysteine ligase catalytic subunit binding | |
| protein heterodimerization activity | H2-Q10;CHUK;NEUROD2;FZD1;SRY;ABTB2;HIST1H2BF;LTC4S;SMAD1 |
GCLM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCLM here. Most of them are supplied by our site. Hope this information will be useful for your research of GCLM.
MCC; ARF6; TNFRSF14; CBWD1; FTSJ1; PHLDA3; CALM1; STOX1; IRF7
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