GDF5
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Official Full Name
growth differentiation factor 5
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Overview
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. -
Synonyms
GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; GDF-5; CDMP-1; radotermin; cartilage-derived morphogenetic protein-1; OS5; LAP4; SYNS2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His(C
- ter)
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GDF5 Related Articles
- GDF5 Related Gene Family
- GDF5 Related Research Area
GDF5 involved in several pathways and played different roles in them. We selected most pathways GDF5 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL1R2;BMPR1BA;ACVR1L;FLT4;TNFRSF6B;IFNA5;Kitl;CXCL12B;IL24 |
TGF-beta signaling pathway | BMP5;GDF6A;RHOAB;RHOAA;LTBP1;ACVR2B;RPS6KB1B;ID3;BMPR1AA |
Hippo signaling pathway | TGFBR2;AFP;PRKCI;TCF7L2;BIRC2;PPP2R2C;YWHAB;AXIN2;APC |
GDF5 has several biochemical functions, for example, BMP binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF5 itself. We selected most functions GDF5 had, and list some proteins which have the same functions with GDF5. You can find most of the proteins on our site.
Function | Related Protein |
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BMP binding | CER1;NBL1;GREM2;BMPR2;HFE2;GREM1;GDF5;TCAP |
cytokine activity | IL17D;CMTM8;Fasl;TGFB2;GM13285;CCL6;INHBA;IFNB1;IL36RN |
growth factor activity | HBEGF;FGF5;TDGF1;BTC;Kitl;BMP7;VEGFA;FGF16;IGF2 |
identical protein binding | GRIN3A;CBX3;CCDC155;CEACAM16;CLDN11;TLE1;MCM6;HSD17B10;LCP1 |
protein binding | HMOX1;RRM2B;SNRPD1;STAG1;HSPE1;MED24;CLPB;AARSD1;TANK |
transforming growth factor beta receptor binding | BMP2B;TGFBR3;GDF15;USP15;GDF9;NDR1;LEFTY1;BMP15;BMP7B |
GDF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF5.
BMPR1B; BMPR1A; NOG; BMPR2
- Q&As
- Reviews
Q&As (5)
Ask a questionGDF5 has been found to stimulate the proliferation and differentiation of chondrocytes, the cells responsible for cartilage formation and maintenance.
Preclinical studies have demonstrated GDF5's ability to promote bone and cartilage regeneration in animal models, providing a foundation for further clinical exploration.
GDF5's specificity for bone and cartilage development distinguishes it from other growth factors, making it a targeted option for orthopedic interventions.
Some studies suggest that combining GDF5 with other growth factors or therapeutic approaches may result in synergistic effects, improving overall outcomes.
While its primary focus is on musculoskeletal conditions, GDF5's role in cellular differentiation opens avenues for exploring its applications in broader regenerative medicine contexts.
Customer Reviews (3)
Write a reviewTheir dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.
Used in protein electron microscopy structure analysis.Great.
By harnessing the power of the GDF5 protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.
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