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GFM2

  • Official Full Name

    G elongation factor, mitochondrial 2

  • Overview

    Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three transcript variants encoding distinct isoforms.
  • Synonyms

    GFM2; G elongation factor, mitochondrial 2; ribosome-releasing factor 2, mitochondrial; EFG2; FLJ21661; MSTP027; mitochondrial elongation factor G2; elongation factor G 2, mitochondrial; mitochondrial ribosome recycling factor 2; RRF2; MRRF2; hEFG2; MST02;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GFM2-13231H Recombinant Human GFM2, GST-tagged E.coli GST 430-779a.a.
Human GFM2-90H Recombinant Human GFM2, His-tagged HEK293 His
Human GFM2-5382HF Recombinant Full Length Human GFM2 Protein, GST-tagged In Vitro Cell Free System GST 779 amino acids
Human GFM2-1731H Recombinant Human GFM2 protein, His & T7-tagged E.coli His/T7 Asn570~Thr779 (Accession # Q969S9)
Human GFM2-4459H Recombinant Human GFM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GFM2-4854H Recombinant Human GFM2 Protein, GST-tagged Wheat Germ GST
Mouse Gfm2-3193M Recombinant Mouse Gfm2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Gfm2-1732M Recombinant Mouse Gfm2 protein, His & T7-tagged E.coli His/T7 Asn569~Leu779 (Accession # Q8R2Q4)
Rat Gfm2-1733R Recombinant Rat Gfm2 protein, His & T7-tagged E.coli His/T7 Asn569~Leu779 (Accession # Q5BJP6)
Rhesus Macaque GFM2-1833R Recombinant Rhesus monkey GFM2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GFM2-1654R Recombinant Rhesus Macaque GFM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GFM2-1654R-B Recombinant Rhesus Macaque GFM2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GFM2-4758Z Recombinant Zebrafish GFM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GFM2 involved in several pathways and played different roles in them. We selected most pathways GFM2 participated on our site, such as Mitochondrial translation, Mitochondrial translation termination, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial translationMTFMT;MTRF1L;MRPS31;MRPL37;MRPS24;MRPL38;MRPL10;MRPL45;ICT1
Mitochondrial translation terminationMRPS27;MRPS31;MRPL55;MRPS33;MRPS28;GFM2;MRPL48;MRPS34;MRPL42
Organelle biogenesis and maintenancePKD1;TNPO1;TCTEX1D2;BBS12;MARK4;MRPL39;MRPL40;MRPL54;TTC30A2

GFM2 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFM2 itself. We selected most functions GFM2 had, and list some proteins which have the same functions with GFM2. You can find most of the proteins on our site.

Function Related Protein
GTP bindingMX1;RAB3DA;TUBA2;RAC1A;RSG1;GTPBP1;SAR1A;GNAO1;RNGTT
GTPase activityARL4C;RAB44;RAB22A;RAB25B;RAB17;GNL3;EIF5;IFT22;HRAS
protein bindingSIN3A;SIN3B;TMEM139;RGS19;SRPK1;DENR;TRAFD1;THEG;LLGL2
NOT translation elongation factor activityGFM2;EFTUD2

GFM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFM2.

TRIM27; VPS52; BANP; TRIM9; SMAD2; SLX4

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