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GFRA4

  • Official Full Name

    GDNF family receptor alpha 4

  • Overview

    The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms

    GFRA4; GDNF family receptor alpha 4; GDNF family receptor alpha-4; persephin receptor; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • CHO
  • HEK293
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GFRA4-715H Recombinant Human GFRA4 Protein, His-tagged CHO His
Human GFRA4-5951HCL Recombinant Human GFRA4 Cell Lysate, transcript variant 1 HEK293 Flag
Human GFRA4-5952HCL Recombinant Human GFRA4 Cell Lysate, transcript variant 2 HEK293 Flag
Rat GFRA4-2515R Recombinant Rat GFRA4 Protein Mammalian Cell His
Rat GFRA4-2171R Recombinant Rat GFRA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GFRA4-2171R-B Recombinant Rat GFRA4 Protein Pre-coupled Magnetic Beads HEK293
Chicken GFRA4-6549C Recombinant Chicken GFRA4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GFRA4 Related Articles
  • GFRA4 Related Gene Family

GFRA4 involved in several pathways and played different roles in them. We selected most pathways GFRA4 participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceMAPK3;AP2A2;SEMA3D;SEMA4D;COL9A3;LIMK1;DUSP2;EPHA5;GPC1A
Developmental BiologyMED22;DAB2IPB;SCN8A;CLASP1;ANK2B;SPTB;SEMA3A;KALRN;COL6A1
NCAM signaling for neurite out-growthGFRA4;COL9A1B;GFRA2;PSPN;GDNF;COL9A1A;NRTN;GFRA1;ST8SIA2
NCAM1 interactionsGFRA4;NRTN;GFRA1;GFRA2;COL9A1A;GDNF;COL9A1B;PSPN

GFRA4 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA4 itself. We selected most functions GFRA4 had, and list some proteins which have the same functions with GFRA4. You can find most of the proteins on our site.

Function Related Protein
glial cell-derived neurotrophic factor receptor activityGFRA1;GFRA4;GFRA2

GFRA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA4.

Liu, W; Rask-Andersen, H; et al. Immunohistological analysis of neurturin and its receptors in human cochlea. AURIS NASUS LARYNX 41:172-178(2014).
Gassei, K; Ehmcke, J; et al. Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men. JOURNAL OF MEDICAL PRIMATOLOGY 39:83-91(2010).
TGF
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