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GGA2

  • Official Full Name

    golgi-associated, gamma adaptin ear containing, ARF binding protein 2

  • Overview

    This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
  • Synonyms

    GGA2; golgi-associated, gamma adaptin ear containing, ARF binding protein 2; ADP-ribosylation factor-binding protein GGA2; KIAA1080; VEAR; ARF-binding protein 2; gamma ear-containing; 1200007E24Rik; ADP ribosylation factor binding protein 2; ADP ribosylation factor binding protein GGA 2; ADP ribosylation factor binding protein GGA2; FLJ20966; Gamma adaptin related protein 2; Gamma-adaptin related protein 2; Gamma-adaptin-related protein 2; GGA 2; GGA2_HUMAN; Golgi associated gamma adaptin ear containing ARF binding protein 2; Golgi localized gamma ear containing ARF binding protein 2; Golgi-localized; VHS domain and ear domain containing protein; VHS domain and ear domain of gamma adaptin; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein; golgi-localized, gamma ear-containing, ARF-binding protein 2; golgi associated, gamma adaptin ear containing, ARF binding protein 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GGA2-5950HCL Recombinant Human GGA2 293 Cell Lysate HEK293 N/A
Human GGA2-5452HF Recombinant Full Length Human GGA2 Protein, GST-tagged In Vitro Cell Free System GST 613 amino acids
Human GGA2-4866H Recombinant Human GGA2 Protein, GST-tagged Wheat Germ GST
Mouse GGA2-6323M Recombinant Mouse GGA2 Protein Mammalian Cell His
Mouse GGA2-3542M Recombinant Mouse GGA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gga2-3198M Recombinant Mouse Gga2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GGA2-3542M-B Recombinant Mouse GGA2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GGA2 Related Articles

GGA2 involved in several pathways and played different roles in them. We selected most pathways GGA2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeAP3B1;ASAH1;AP4E1;AP3M2;M6PR;ATP6V0A2B;ATP6V0CA;SLC11A1;ATP6V0A4

GGA2 has several biochemical functions, for example, ADP-ribosylation factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GGA2 itself. We selected most functions GGA2 had, and list some proteins which have the same functions with GGA2. You can find most of the proteins on our site.

Function Related Protein
ADP-ribosylation factor bindingRAB11FIP4B;GRASP;ADCYAP1R1;RAB11FIP4;GGA3;ZFP652;RAB11FIP4A;GGA2;RAB11FIP3
protein bindingLDLRAP1;CENPO;TNPO1;KIF27;CDC45;COASY;APIP;NCKAP1L;TMEM59

GGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGA2.

RABEP1; SORT1; CLTC; CA8; IGF2R; ARF1

Sun, YF; Liu, RR; et al. Genome-Wide Linkage Analysis and Association Study Identifies Loci for Polydactyly in Chickens. G3-GENES GENOMES GENETICS 4:1167-1172(2014).
Doray, B; Govero, J; et al. Impact of Genetic Background on Neonatal Lethality of Gga2 Gene-Trap Mice. G3-GENES GENOMES GENETICS 4:885-890(2014).
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