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GGT5

Official Full Name

gamma-glutamyltransferase 5
Overview

This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesnt convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms

GGT5; gamma-glutamyltransferase 5; gamma glutamyltransferase like activity 1 , GGTLA1; GGT REL; DKFZP566O011; Gamma glutamyl transpeptidase related enzyme; Gamma glutamyltranspeptidase 5; GGT 5; gamma-glutamyl cleaving enzyme; gamma-glutamyltranspeptidase 5; gamma-glutamyltransferase-like activity 1; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein; GGTLA1; GGT-REL;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Homo sapiens (Human)
Human

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GGT5-773H	Recombinant Human GGT5 protein(Ser30-Tyr586), His-tagged	HEK293	N-His	Ser30-Tyr586	Inquiry
Human	GGT5-13244H	Recombinant Human GGT5, GST-tagged	E.coli	GST	C-term-300a.a.	$319 / 25ug
Human	GGT5-1145H	Recombinant Human GGT5 protein, His & T7-tagged	E.coli	His/T7	Thr388~Tyr586 (Accession # P36269)	Inquiry
Human	GGT5-702HCL	Recombinant Human GGT5 cell lysate		N/A		Inquiry
Human	GGT5-2699H	Recombinant Human GGT5 Protein (Thr388-Tyr586), N-His tagged	E.coli	N-His	Thr388-Tyr586	Inquiry
Human	GGT5-4879H	Recombinant Human GGT5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GGT5-5243HF	Recombinant Full Length Human GGT5 Protein, GST-tagged	In Vitro Cell Free System	GST	587 amino acids	Inquiry
Homo sapiens (Human)	RFL35956HF	Recombinant Full Length Human Gamma-Glutamyltransferase 5(Ggt5) Protein, His-Tagged	E.coli expression system	His	Full Length (1-387)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GGT5 Related Articles
GGT5 Related Research Area

GGT5 involved in several pathways and played different roles in them. We selected most pathways GGT5 participated on our site, such as Taurine and hypotaurine metabolism, Cyanoamino acid metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Taurine and hypotaurine metabolism	GGT5;CDO1;ADOB;CSAD;GAD1;GGT7;BAAT;GAD1B;ADO
Cyanoamino acid metabolism	GGT1A;GGT6;GBA3;GGT5;GGT5A;SHMT1;GGT1;GGT7;SHMT2
Glutathione metabolism	GSTO1;GSTM6;PGD;GPX1A;GGCT;GCLM;GSTT1;ANPEPB;LAP3
Arachidonic acid metabolism	CYP2P7;GGT5;GPX6;GGTLC1;CYP2C38;ALOX8;PTGDS;FAAH2B;CYP2C50
Metabolic pathways	ADH2-1;PI4K2A;PIGV;ATP5IA;AGXT2L2;CYP3A41A;AMY2A4;ALDH9A1B;CYP19A1B

GGT5 has several biochemical functions, for example, gamma-glutamyltransferase activity, glutathione hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGT5 itself. We selected most functions GGT5 had, and list some proteins which have the same functions with GGT5. You can find most of the proteins on our site.

Function	Related Protein
gamma-glutamyltransferase activity	GGT5A;GGT7;GGT5;GGTLC1;GGT1;GGT6;GGT1A
glutathione hydrolase activity	GGT1;GGT5;GGT6;GGT7

GGT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGT5.

Sket, P; Korbar, T; et al. Influence of 3 '-3 ' inversion of polarity site within d(TGGGGT) on inter quartet cation binding. JOURNAL OF MOLECULAR STRUCTURE 1075:49-52(2014).

Serizawa, M; Kusuhara, M; et al. Identification of Metabolic Signatures Associated with Erlotinib Resistance of Non-small Cell Lung Cancer Cells. ANTICANCER RESEARCH 34:2779-2787(2014).

Fatty Acid Catabolism

Eicosanoids and Regulators