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GIPR

  • Official Full Name

    gastric inhibitory polypeptide receptor

  • Overview

    Gastric Inhibitory Polypeptide Receptor is a member of the G protein-coupled receptor (GPCR, or GPR) family (subfamily Gastric inhibitory polypeptide). Members of this family contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Gastric inhibitory polypeptide receptor is a receptor for gastric inhibitory polypeptide (GIP), this is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food- dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.
  • Synonyms

    GIPR; gastric inhibitory polypeptide receptor; PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor; MGC126722; GIP; Gastric Inhibitory Peptide;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • Myc
  • MBP
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GIPR-22H Active Recombinant Human GIPR Fc Chimera HEK293T
Human GIPR-203H Active Acitive Recombinant Human GIPR Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human GIPR-13267H Recombinant Human GIPR, GST-tagged E.coli GST 25-142a.a.
Human GIPR-294HCL Recombinant Human GIPR HEK293T Over-expression Lysate HEK293T Myc/DDK
Human GIPR-1355H Recombinant Human GIPR protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gly 26 - Gln 138
Human GIPR-2961H Recombinant Human GIPR protein, His-tagged E.coli His 22-138aa
Human GIPR-2220H Recombinant Human GIPR protein, His&Myc-tagged Insect Cell His&Myc 22-138aa
Human GIPR-1107HFL Recombinant Human GIPR protein, His&Flag-tagged HEK293 His&Flag 1-466 aa
Human GIPR-5016H Recombinant Human GIPR protein, His&Myc-tagged HEK293 His&Myc 22-138aa
Human GIPR-1354H Recombinant Human GIPR protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi 22-138aa
Human GIPR-1912H Recombinant Human GIPR Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 22-466aa
Mouse Gipr-1167M Recombinant Mouse Gipr protein, His&Myc-tagged E.coli His&Myc 19-134aa
Rat GIPR-2543R Recombinant Rat GIPR Protein Mammalian Cell His
Rat GIPR-2199R Recombinant Rat GIPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GIPR-2199R-B Recombinant Rat GIPR Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL32302HF Recombinant Full Length Human Gastric Inhibitory Polypeptide Receptor(Gipr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-466)
Mesocricetus auratus (Golden hamster) RFL9002MF Recombinant Full Length Mesocricetus Auratus Gastric Inhibitory Polypeptide Receptor(Gipr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-462)
Mus musculus (Mouse) RFL11621MF Recombinant Full Length Mouse Gastric Inhibitory Polypeptide Receptor(Gipr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-460)
Rattus norvegicus (Rat) RFL12063RF Recombinant Full Length Rat Gastric Inhibitory Polypeptide Receptor(Gipr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-455)
Chicken GIPR-3733C Recombinant Chicken GIPR Mammalian Cell His
Kit-1094 Hydrogen Peroxide Colorimetric/Fluorometric Assay Kit N/A
Kit-1002 Methanol Assay Kit (Colorimetric) N/A
Kit-1258 cAMP GIPR CHO-K1 GPCR Assay Kit N/A
Kit-1257 GIPR CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GIPR Related Articles

GIPR involved in several pathways and played different roles in them. We selected most pathways GIPR participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayLOC100328615;RHOA;ATP2A2;CREB3L3;PLCE1;PPP1R12A;PLD1;PDE4B;NFKB1
Neuroactive ligand-receptor interactionNMUR1;GLRA1;CCKAR;NPFFR2;GNRHR2;APLNRA;OPRM1;MC5RA;HTR1E

GIPR has several biochemical functions, for example, gastric inhibitory peptide receptor activity, peptide hormone binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GIPR itself. We selected most functions GIPR had, and list some proteins which have the same functions with GIPR. You can find most of the proteins on our site.

Function Related Protein
gastric inhibitory peptide receptor activity
peptide hormone bindingNPR3;CRHR2;NPR2;PTH1RB;AGTR1B;GHRHR;GALR1;GHSR;GIPR
transmembrane signaling receptor activityBAI2;TLR5;KLRF1;EGFR;SLAMF1;FZD8A;MARCO;OR6K3;LGR4

GIPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GIPR.

Chen, S; Okahara, F; et al. Increased GIP signaling induces adipose inflammation via a HIF-1 alpha-dependent pathway and impairs insulin sensitivity in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 308:E414-E425(2015).
Keyhani-Nejad, F; Irmler, M; et al. Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice. DIABETOLOGIA 58:374-383(2015).
  • Q&As
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