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GJA4

  • Official Full Name

    gap junction protein, alpha 4, 37kDa

  • Overview

    This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.
  • Synonyms

    GJA4; gap junction protein, alpha 4, 37kDa; gap junction protein, alpha 4, 37kD (connexin 37) , gap junction protein, alpha 4, 37kDa (connexin 37); gap junction alpha-4 protein; connexin 37; CX37; Connexin-37; CXA4_HUMAN; Gap junction alpha 4 protein; gap junction protein, alpha 4 37kDa (connexin 37); gap junction protein, alpha 4, 37kD (connexin 37); OTTHUMP00000004181; OTTHUMP00000004182;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GJA4-26253TH Recombinant Human GJA4 Wheat Germ N/A 333 amino acids
Human GJA4-6996H Recombinant Human GJA4 protein, His-tagged E.coli His Val79~Ser328 (Accession # P35212)
Human GJA4-5922HCL Recombinant Human GJA4 293 Cell Lysate HEK293 N/A
Human GJA4-191HF Recombinant Full Length Human GJA4 Protein In Vitro Cell Free System 333 amino acids
Human GJA4-4922H Recombinant Human GJA4 Protein, GST-tagged Wheat Germ GST
Human GJA4-5291HF Recombinant Full Length Human GJA4 Protein, GST-tagged In Vitro Cell Free System GST 333 amino acids
Mouse GJA4-6370M Recombinant Mouse GJA4 Protein Mammalian Cell His
Mouse Gja4-6997M Recombinant Mouse Gja4 protein, His & GST-tagged E.coli His/GST Thr19~Asp245 (Accession # P28235)
Mouse GJA4-3571M-B Recombinant Mouse GJA4 Protein Pre-coupled Magnetic Beads HEK293
Mouse GJA4-3571M Recombinant Mouse GJA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GJA4-2547R Recombinant Rat GJA4 Protein Mammalian Cell His
Rat GJA4-2203R-B Recombinant Rat GJA4 Protein Pre-coupled Magnetic Beads HEK293
Rat GJA4-2203R Recombinant Rat GJA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL7509BF Recombinant Full Length Bovine Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-333)
Homo sapiens (Human) RFL19593HF Recombinant Full Length Human Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-333)
Mus musculus (Mouse) RFL35221MF Recombinant Full Length Mouse Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-333)
Rattus norvegicus (Rat) RFL12524RF Recombinant Full Length Rat Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-333)
Xenopus laevis (African clawed frog) RFL2986XF Recombinant Full Length Xenopus Laevis Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-352)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL29813XF Recombinant Full Length Xenopus Tropicalis Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-352)
Chicken GJA4-7107C Recombinant Chicken GJA4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GJA4 Related Articles
  • GJA4 Related Research Area

GJA4 involved in several pathways and played different roles in them. We selected most pathways GJA4 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium Regulation in the Cardiac CellRGS11;CX34.4;RGS14;CASQ2;CX35.4;RGS18;RGS17;RGS10;GJC2
Gap junction assemblyGJB2;CX30.3;GJA4;GJB4;CX27.5;GJB3;GJC1;GJB7;GJA5
Gap junction traffickingMYO6B;GJB7;GJB4;CX30.3;GJB2;GJA5;GJA8;MYO6;GJA4
Gap junction trafficking and regulationCX30.3;CX27.5;GJA8;GJB5;MYO6B;MYO6;GJA4;GJD3;GJB3
Membrane TraffickingCNIH2;BLOC1S1;TERFA;TMED2;SEC16B;FTH1A;TGOLN2;GORASP1;FTH1B
Ovarian Infertility GenesMSH5;DAZL;DMC1;ZP2;SYNE2;NRIP1;INHA;NR5A1;ZP3
Vesicle-mediated transportDTNBP1;TPD52L1;RAB10;TRAPPC2L;TRAPPC6BL;HYOU1;SEC16B;TRAPPC3;GJB3

GJA4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA4 itself. We selected most functions GJA4 had, and list some proteins which have the same functions with GJA4. You can find most of the proteins on our site.

Function Related Protein
protein bindingFRMD8;MXD3;A1CF;UBE2H;USHBP1;HTR6;PHYH;GJA1;RARG

GJA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA4.

OPRM1; Oprd1; OPRK1

Luana, NT; Sharma, N; et al. Characterization and cardiac differentiation of chicken spermatogonial stem cells. ANIMAL REPRODUCTION SCIENCE 151:244-255(2014).
Berthoud, VM; Minogue, PJ; et al. Connexin50D47A Decreases Levels of Fiber Cell Connexins and Impairs Lens Fiber Cell Differentiation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:7614-7622(2013).
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