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GLB1

  • Official Full Name

    galactosidase, beta 1

  • Overview

    This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GLB1; galactosidase, beta 1; elastin receptor 1 (67kD) , elastin receptor 1, 67kDa , ELNR1; beta-galactosidase; EBP; Acid beta galactosidase; Acid beta-galactosidase; Beta galactosidase; BGAL_HUMAN; Elastin receptor 1 (67kD); Elastin receptor 1 67kDa; Elastin receptor 1; ELNR1; Galactosidase beta 1; GLB 1; Lactase; OTTHUMP00000208610; OTTHUMP00000208611; OTTHUMP00000208612; elastin receptor 1, 67kDa; MPS4B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLB1-174H Active Recombinant Human GLB1 protein, His-tagged CHO His
Human GLB1-7790H Active Recombinant Human GLB1, His-tagged CHO His
Human GLB1-13292H Recombinant Human GLB1, His-tagged E.coli His 329-677a.a.
Human GLB1-7758H Recombinant Human GLB1 protein, His-tagged HEK293 His
Human GLB1-180H Recombinant Human GLB1 Protein, His-tagged E.coli His Arg68~Thr219
Human GLB1-5909HCL Recombinant Human GLB1 293 Cell Lysate HEK293 N/A
Human GLB1-5910HCL Recombinant Human GLB1 293 Cell Lysate HEK293 N/A
Human GLB1-4945H Recombinant Human GLB1 Protein, GST-tagged Wheat Germ GST
Human GLB1-3994H Recombinant Human GLB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GLB1-5308HF Recombinant Full Length Human GLB1 Protein, GST-tagged In Vitro Cell Free System GST 677 amino acids
Human GLB1-2399H Recombinant Human GLB1 Protein (Arg68-Thr219), His tagged E.coli His Arg68-Thr219
Human GLB1-417HFL Recombinant Full Length Human GLB1 Protein, C-Flag-tagged Mammalian cells Flag
Human GLB1-984H-B Recombinant Human GLB1 Protein Pre-coupled Magnetic Beads HEK293
Human GLB1-984H Recombinant Human GLB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GLB1-1107H Recombinant Human GLB1 Protein (Leu24-Val677), C-His tagged Mammalian cells C-His Leu24-Val677
Mouse GLB1-6392M Recombinant Mouse GLB1 Protein Mammalian Cell His
Mouse Glb1-181M Recombinant Mouse Glb1 Protein, His-tagged E.coli His Ser192~Pro432
Mouse GLB1-3587M-B Recombinant Mouse GLB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GLB1-3587M Recombinant Mouse GLB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Glb1-706M Recombinant Mouse Glb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Glb1-182R Recombinant Rat Glb1 Protein, His-tagged E.coli His Leu338~Asp570
Rat Gp9-183R Recombinant Rat Gp9 Protein, His/GST-tagged E.coli His/GST Met1~Asn189
Rat Gp9-184R Recombinant Rat Gp9 Protein, His-tagged E.coli His Met1~Trp161
Zebrafish GLB1-2329Z Recombinant Zebrafish GLB1 Mammalian Cell His
Chicken GLB1-5396C Recombinant Chicken GLB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GLB1 Related Research Area

GLB1 involved in several pathways and played different roles in them. We selected most pathways GLB1 participated on our site, such as Galactose metabolism, Other glycan degradation, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Galactose metabolismPGM2;PFKMA;GALM;HKDC1;UGP2B;GALT;G6PCA.2;LCT;G6PC
Other glycan degradationNEU3.5;ENGASE;HEXDC;MANBA;NEU3.4;FUCA1.2;AGA;NEU2;FUCA1.1
Glycosaminoglycan degradationGUSB;HGSNAT;GNSA;GALNS;ARSB;HYAL2;GLB1;HYAL3;HEXA
Sphingolipid metabolismNEU3.3;COL4A3BP;R05D11.9;SUMF2;ARSK;PPAP2B;ASAH1B;PPAP2C;GALCB
Glycosphingolipid biosynthesis - ganglio seriesST3GAL2;ST6GALNAC4;ST6GALNAC6;GLB1;ST8SIA1;B4GALNT1;HEXB;ST8SIA5;ST3GAL5
Metabolic pathwaysH2-KE6;COX7C;PIP5K1A;FPGT;ALDOC;RABGNT1;ALPI.2;LIAS;POLR2A
LysosomeASAH1;GALCA;LAPTM4B;CLTCB;CLN5;FAM49BA;CTSM;CTSSB.1;ATP6V0A2B

GLB1 has several biochemical functions, for example, beta-galactosidase activity, galactoside binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLB1 itself. We selected most functions GLB1 had, and list some proteins which have the same functions with GLB1. You can find most of the proteins on our site.

Function Related Protein
beta-galactosidase activityGLB1L3;GLB1L;GLB1;GLB1L2;GBA3
galactoside bindingGLB1;LGALS3L;LGALS1L1;LGALS2A;GLA;LGALS2;LGALS2B;LGALS9L1
protein bindingHUWE1;DNMT3B;BAHD1;G3BP2;TRA2B;TCF7;WHRN;TSPAN15;KMT2E

GLB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLB1.

CTNNBIP1; FOS; TK1; PLK1; CSNK2B; NEU1; A2M; cona_canen; ELN; H2AFX

  • Q&As
  • Reviews

Q&As (5)

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How does GLB1 protein deficiency impact the nervous system? 07/04/2022

GLB1 deficiency can lead to neurodegeneration, causing progressive deterioration of the nervous system.

What are the different subtypes of GLB1 deficiency? 02/15/2020

There are three subtypes: GM1 gangliosidosis, mucopolysaccharidosis IVB, and combined GM1 gangliosidosis and mucopolysaccharidosis IVB.

Can GLB1 deficiency be managed through dietary interventions? 12/11/2019

While dietary interventions may help manage certain symptoms, they do not address the underlying cause of the deficiency.

What are the symptoms of GLB1 deficiency? 08/29/2018

Symptoms may include developmental delay, skeletal abnormalities, vision and hearing loss, and neurological deterioration.

Can GLB1 deficiency be detected prenatally? 05/21/2016

Yes, prenatal testing through genetic analysis of amniotic fluid or chorionic villus sampling can detect GLB1 deficiency.

Customer Reviews (3)

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Reviews
12/10/2021

    Their support has been invaluable in troubleshooting and providing efficient solutions, enhancing the overall efficiency and productivity of my experiments.

    04/03/2019

      Its versatility allows for exploring its various roles and functions, shedding light on its significance in crucial biochemical pathways and cellular processes.

      05/16/2016

        Their knowledgeable and responsive team has consistently demonstrated their ability to address any concerns or challenges I have encountered along the way.

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