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GNA11

  • Official Full Name

    GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [ Homo sapiens ]

  • Overview

    This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.
  • Synonyms

    guanine nucleotide binding protein (G protein), alpha 11 (Gq class); 4379; Ensembl:ENSG00000088256; guanine nucleotide-binding protein subunit alpha-11; g alpha-11; G-protein subunit alpha-11; guanine nucleotide-binding protein, Gq class, GNA11; guanine nucleotide-binding protein G(y) subunit alpha; GNA-11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNA11-22H Recombinant Human GNA11, GST-tagged Wheat Germ GST
Human GNA11-13342H Recombinant Human GNA11, His-tagged E.coli His 1-170a.a.
Human GNA11-186H Recombinant Human GNA11 protein, GST-tagged E.coli GST
Human GNA11-5872HCL Recombinant Human GNA11 293 Cell Lysate HEK293 N/A
Human GNA11-995H-B Recombinant Human GNA11 Protein Pre-coupled Magnetic Beads HEK293
Human GNA11-6939HF Recombinant Full Length Human GNA11 Protein, GST-tagged In Vitro Cell Free System GST 359 amino acids
Human GNA11-3051H Recombinant Human GNA11 Protein (Met1-Val359), N-His tagged E.coli N-His Met1-Val359
Human GNA11-1479HFL Recombinant Full Length Human GNA11 Protein, C-Flag-tagged Mammalian cells Flag
Human GNA11-3785H Recombinant Human GNA11 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GNA11-995H Recombinant Human GNA11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNA11-7009M Recombinant Mouse GNA11 Protein Mammalian Cell His
Mouse Gna11-3253M Recombinant Mouse Gna11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GNA11-3752M Recombinant Mouse GNA11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNA11-3752M-B Recombinant Mouse GNA11 Protein Pre-coupled Magnetic Beads HEK293
Rat GNA11-2590R Recombinant Rat GNA11 Protein Mammalian Cell His
Rat GNA11-2245R-B Recombinant Rat GNA11 Protein Pre-coupled Magnetic Beads HEK293
Rat GNA11-2245R Recombinant Rat GNA11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GNA11-1889R Recombinant Rhesus monkey GNA11 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GNA11-1709R Recombinant Rhesus Macaque GNA11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GNA11-1709R-B Recombinant Rhesus Macaque GNA11 Protein Pre-coupled Magnetic Beads HEK293
Chicken GNA11-5807C Recombinant Chicken GNA11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GNA11 Related Articles

GNA11 involved in several pathways and played different roles in them. We selected most pathways GNA11 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNA11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayERBB4;HTR6;AVPR1A;ADRB2A;PRKCG;PLCZ1;HTR2A;GNAQ;CHRNA7
cGMP-PKG signaling pathwayBNP;TRPC6;CALM1;IRS2;MAP2K2;ATP1B2;PLN;VASP;PLCB2
Vascular smooth muscle contractionPRKACA;GUCY1B3;CALM1;PRKCH;GNA13A;PRKACB;PLA2G2E;MYL6B;CYP4A12A
Gap junctionTUBA8L2;DRD1A;PRKCBB;PLCB4;NRAS;TUBA3C;GRM5;PRKACG;TJP1
Cholinergic synapseCHRNA6;HRAS;KCNJ4;GNB1;FOS;PLCB4;PIK3R3;KCNJ14;GNAO1
Long-term depressionBRAF;GNAI2;IGF1R;HRAS;LYN;PLA2G4F;GRM1;KRAS;PRKCG
Insulin secretionPLCB3;FFAR1;VAMP2;ATP1A3;FXYD2;PLCB1;INS1;PLCB4;GIP
GnRH signaling pathwayRAF1;Adcy4;MAPK7;GNA11B;MAP2K2;MAPK10;ITPR3;LHBETA1;GNRHR1
Aldosterone synthesis and secretionCALM1;CACNA1G;PRKACA;KCNK3;PRKD3;AGTR1;ADCY8;ITPR1;NR4A1
Chagas disease (American trypanosomiasis)IL10;NOS2;IFNGR1;C1QC;CD247;PPP2R2C;PIK3CB;TNF;C3
AmoebiasisLAMB1;SERPINB6;SERPINB2;IL1R1;LAMA4;GM-CSF;TGFB1;PRKACA;ADCY1
Pathways in cancerRELA;CXCR4;FIGF;RXRB;GNG13;PLCG2;PGF;WNT5A;LAMA1

GNA11 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNA11 itself. We selected most functions GNA11 had, and list some proteins which have the same functions with GNA11. You can find most of the proteins on our site.

Function Related Protein
G-protein beta/gamma-subunit complex bindingCETN4;GNA14;CETN2;GNAI3;GNAI1;GNAI2;GNAO1A;GNA13A;GNAIA
GTP bindingTUFM;HHAT;ARF4A;TUBB;MX2;RAP1B;RND3B;GMPPAA;GNAO1
GTPase activityRAB5B;RAB25A;GNA11B;RAB3C;RAB33B;HRAS;GTPBP4;EIF5;AGAP2
metal ion bindingRRM2;PDCD2;NOX1;PVALB4;ADNP2A;ZNF664;BMPR1BA;PDE4C;JAZF1B
signal transducer activityTAS2R143;ADCYAP1R1A;SLC20A1;MTNR1AL;MRGPRB1;VAPA;GNG8;OPN1MW1;SP110
type 2A serotonin receptor bindingGNA11;ARRB2;GNAQ

GNA11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNA11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNA11.

q5ni24_fratt; pi3p; CFTR; Tpm1; Actb; TMEM63B; Coro1c

Koelsche, C; Hovestadt, V; et al. Melanotic Tumors of the Nervous System are Characterized by Distinct Mutational, Chromosomal and Epigenomic Profiles. BRAIN PATHOLOGY 25:202-208(2015).
Kusters-Vandevelde, HVN; Kusters, B; et al. Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects. BRAIN PATHOLOGY 25:209-226(2015).
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