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GNAI2

  • Official Full Name

    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

  • Overview

    Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.
  • Synonyms

    Giα-2-Subunit; GNAI2; Guanine nucleotide-binding protein G(i), alpha-2 subunit; Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1; guanine nucleotide-binding protein G(i) subunit alpha-2; OTTHUMP00000211065; OTTHUMP00000211066; OTTHUMP00000211067; OTTHUMP00000211070; adenylate cyclase-inhibiting G alpha protein; GTP-binding regulatory protein Gi alpha-2 chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNAI2-190H Active Recombinant Human GNAI2 protein, GST-tagged E.coli GST 2-end
Human GNAI2-28964TH Recombinant Human GNAI2, His-tagged E.coli His
Human GNAI2-7152H Recombinant Human Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2, His-tagged E.coli His 1-355aa
Human GNAI2-31549TH Recombinant Human Human ADRB2 Flag/His
Human GNAI2-31364TH Recombinant Human Human Human Human FPR1 Flag/His
Human GNAI2-31551TH Recombinant Human Human Human Human GNB1 Flag/His
Human GNAI2-5870HCL Recombinant Human GNAI2 293 Cell Lysate HEK293 N/A
Human GNAI2-944HFL Recombinant Full Length Human GNAI2 Protein, C-Flag-tagged Mammalian cells Flag
Human GNAI2-5323HF Recombinant Full Length Human GNAI2 Protein, GST-tagged In Vitro Cell Free System GST 339 amino acids
Human GNAI2-3766H Recombinant Human GNAI2 protein, GST-tagged E.coli GST 1-355 aa
Human GNAI2-5042H Recombinant Human GNAI2 Protein, GST-tagged Wheat Germ GST
Human GNAI2-996H Recombinant Human GNAI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GNAI2-996H-B Recombinant Human GNAI2 Protein Pre-coupled Magnetic Beads HEK293
Mouse GNAI2-7015M Recombinant Mouse GNAI2 Protein Mammalian Cell His
Mouse Gnai2-3255M Recombinant Mouse Gnai2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GNAI2-3757M-B Recombinant Mouse GNAI2 Protein Pre-coupled Magnetic Beads HEK293
Mouse GNAI2-3757M Recombinant Mouse GNAI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gnai2-5898M Recombinant Mouse Gnai2 protein, His&Myc-tagged Insect Cell His&Myc 2-355aa
Mouse Gnai2-1229M Recombinant Mouse Gnai2 protein, His-tagged E.coli His 2-355aa
Rat GNAI2-2594R Recombinant Rat GNAI2 Protein Mammalian Cell His
Rat GNAI2-2249R Recombinant Rat GNAI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GNAI2-2249R-B Recombinant Rat GNAI2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GNAI2-555C Recombinant Cynomolgus GNAI2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GNAI2-300C Recombinant Cynomolgus Monkey GNAI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GNAI2-300C-B Recombinant Cynomolgus Monkey GNAI2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GNAI2-1891R Recombinant Rhesus monkey GNAI2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GNAI2-1711R-B Recombinant Rhesus Macaque GNAI2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GNAI2-1711R Recombinant Rhesus Macaque GNAI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GNAI2-6953C Recombinant Chicken GNAI2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GNAI2 involved in several pathways and played different roles in them. We selected most pathways GNAI2 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayHGF;SIPA1L2;MAP2K2;ACTB;ANGPT4;FGF14;PDGFA;FGF8;GNAS
cGMP-PKG signaling pathwayPLN;GATA4;ATP1B2;ATP1A4;MEF2A;SLC25A4;ATP2B4;KCNMB3;AKT2
cAMP signaling pathwayAKT1;RAC2;ROCK1;ARAP3;NFKB1;PPP1CA;NFKBIA;BDNF;SLC9A1
Chemokine signaling pathwayCXCL16;STAT5B;Ccl27a;GNG11;GNG8;GNG10;GRK1;CCL6;ADRBK2
Sphingolipid signaling pathwayRAF1;ROCK1;LOC100328615;S1PR2;BID;BCL2;NFKB1;SPTLC2;SPHK2
Adrenergic signaling in cardiomyocytesMAPK11;SCN1BA;BCL2;ATP1B3A;ADCY2B;ATP1A3B;PPP2R5CB;Adcy4;ADCY7
Axon guidanceEPHA8;FGF8B;EFNB2;PLXNA3;KIF4;DPYSL2B;NRG4;Sema3f;ROCK2
Tight junctionPRKCZ;PTENA;RHOAA;LLGL2;F11R.1;MYH9A;CLDND;PTENB;CRB3A
Gap junctionDRD1B;TUBA3B;Pdgfa&Pdgfb;DRD2A;HTR2B;TUBA8L;MAP2K2;TUBB2;ADCY1B
Platelet activationMYL12B;MYL12A;ROCK1;PRKACB;GUCY1A3;P2RY1;SNAP23;ORAI1;ARHGAP35
Leukocyte transendothelial migrationMYL9;VCAM1;ARHGAP35;CLDN6;PXN;PIK3R2;CTNNA3;VAV3;CLDN20
Circadian entrainmentCAMK2B;Adcy4;GNG10;PRKACB;GRIN2C;PER1;CALM1;GRIN1;GRIN2A
Retrograde endocannabinoid signalingGNG2;SLC17A6;GNB2;GNG12;MAPK10;GABRD;GABRA4;GABRQ;GABRA3
Glutamatergic synapseGNGT1;GNAI3;GRIA2;PLCB4;GRIA3;GRM1;PLCB3;SHANK3;SLC38A1
Cholinergic synapsePLCB4;GNAQ;KCNJ3;CHRNA3;CHRNA6;CHRNA7;GNG8;CHRM5;GNG13
Serotonergic synapseMAP2K1;MAPK3;GNB1;SLC18A1;PLCB4;CYP2J6;GNG13;PLCB2;GNG2
GABAergic synapseGABBR2;GNB3;GABARAPL1;GABRR1;GABARAP;SLC38A3;PRKCB;GNAI1;PRKCG
Dopaminergic synapseDRD2;KCNJ6;GNB4;DDC;GRIA4;PPP3CA;DRD3;GNB3;PPP2R1B
Long-term depressionPLA2G4C;PPP2R1B;CRHR1;HRAS;GRM1;PPP1R17;PRKCB;RYR1;MAP2K2
Progesterone-mediated oocyte maturationMAPK3;CCNB2;ANAPC13;CDH1-A;ANAPC7;GNAI2B;RAF1B;MAPK10;RPS6KA1
Estrogen signaling pathwayPRKACA;Adcy4;HSPA1A;PIK3CD;PLCB4;KCNJ3;HSPA1L;FKBP5;PRKCD
MelanogenesisGNA11A;PRKACA;FZD8A;GNAO1;TCF7L1A;HRASB;EP300;WNT5A;WNT1
Oxytocin signaling pathwayPPP1R12B;KCNJ14;CACNG6;RGS2;PRKAB1;PPP1R12A;PIK3CA;KRAS;PRKAG2
Regulation of lipolysis in adipocytesNPR1;PIK3R3;INS1;AQP7;AKT1;PRKG1;PTGS2;AKT2;PLIN1
Renin secretionGUCY1B3;CLCA3;CALM1;CLCA4;PDE3B;PRKG2;PDE3A;ACE;ITPR1
Gastric acid secretionKCNJ1;EZR;CALML5;CALM4;GNAI3;PRKACG;GNAS;ATP1A3;ATP1B4
Parkinsons diseaseATP5H;NDUFS2;NDUFS1;NDUFS3;GNAI1;NDUFA5;UQCRH;COX7B;PARK7
Cocaine addictionRGS9;GRIN2A;ATF4;PRKACB;MAOA;RELA;GRIN2B;BDNF;GRM3
AlcoholismHIST1H2BK;HIST1H3A;HDAC5;HIST1H4B;GNG10;HIST1H3I;CALM1;HIST1H2AM;HIST3H2A
PertussisMAPK8;C1QC;CALML3;CASP7;IRAK1;C3;MAPK12;IL12B;CALM2
Chagas disease (American trypanosomiasis)PLCB4;CCL3;IKBKG;MAPK12;PPP2R2A;TLR9;IRAK1;PIK3CA;CFLAR
ToxoplasmosisGNAO1;LAMA3;HLA-DRA;MAPK1;IRAK1;CD40LG;MAPK3;PIK3R2;MAP2K6
Pathways in cancerF2RL3;FGF11;WNT2;RARB;GNG5;TPR;ITGB1;HGF;CBLB

GNAI2 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI2 itself. We selected most functions GNAI2 had, and list some proteins which have the same functions with GNAI2. You can find most of the proteins on our site.

Function Related Protein
G-protein beta/gamma-subunit complex bindingGNAI2A;GNAV1;GNA11A;PIK3R5;GNA12A;GNA14;GNAI2B;GNA13B;GNA11B
G-protein coupled receptor bindingINSL3;RSPO1;S1PR2;HSPA1A;POMC;RLN3;ARRB2;GNAL;GNA12A
GTP bindingAGAP1;ARL4CB;RASL10B;DNM2B;DNAJC27;RAB33B;DNM3A;EHD4;AK3
GTPase activityRAB18A;RAB31;GNL1;MFN1B;TUBG1;RHOT1A;NUDT1;MTIF2;RRAGC
metal ion bindingZFP932;ZNF292A;BCO2;FIZ1;ACLY;LTN1;CRYAB;HBBE3;CPEB1B
protein bindingPIP;CD46;IRF4;XAGE2;LILRB2;GAP43;NPPB;CALU;SP2
signal transducer activityTAS2R202;TAS2R138;SHC3;IRS4;GPR34A;OLFR867;MAGI2;PPP1R12A;ADRA2DB

GNAI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI2.

CXCR5; MDFI; NCF2; RGS20; HSP90AB1

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