Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

GNB2

Official Full Name

guanine nucleotide binding protein (G protein), beta polypeptide 2
Overview

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5 UTR.
Synonyms

GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein; beta 2 subunit; guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 2; signal transducing gua;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNB2-13355H	Recombinant Human GNB2, His-tagged	E.coli	His	1-340a.a.	$319 / 25ug
Human	GNB2-5863HCL	Recombinant Human GNB2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNB2-5358HF	Recombinant Full Length Human GNB2 Protein, GST-tagged	In Vitro Cell Free System	GST	340 amino acids	Inquiry
Human	GNB2-5215H	Recombinant Human GNB2 protein, GST-tagged	E.coli	GST	21-327aa	Inquiry
Human	GNB2-5054H	Recombinant Human GNB2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GNB2-3346H	Recombinant Human GNB2 Protein (Ser2-Asn340), N-His tagged	E.coli	N-His	Ser2-Asn340	Inquiry
Mouse	GNB2-7027M	Recombinant Mouse GNB2 Protein	Mammalian Cell	His		Inquiry
Mouse	GNB2-3766M-B	Recombinant Mouse GNB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GNB2-3766M	Recombinant Mouse GNB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GNB2-2601R	Recombinant Rat GNB2 Protein	Mammalian Cell	His		Inquiry
Rat	GNB2-2256R	Recombinant Rat GNB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GNB2-2256R-B	Recombinant Rat GNB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GNB2-2167Z	Recombinant Zebrafish GNB2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GNB2 Related Articles

GNB2 involved in several pathways and played different roles in them. We selected most pathways GNB2 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	PDGFB;PLA2G4C;SHC2;PLA2G6;NGF;IKBKB;GNG11;PRKCG;PAK2
Chemokine signaling pathway	CXCL1;PTK2;CCL3L1;AKT2;CRKL;GRK7;ARRB2;PIK3CB;LYN
PIK-Akt signaling pathway	PRKAA1;Il6ra;ITGA2B;ANGPT1;ITGB6;GNB2;FGF6;FGF7;FASLG
Circadian entrainment	GNAQ;GRIA4;PRKCG;GNB3;GNAO1;GNAI2;CAMK2D;GNG11;RYR2
Retrograde endocannabinoid signaling	GNGT1;GABRG1;PRKCB;GABRE;PLCB4;GABRR2;GABRA1;MAPK1;MAPK12
Glutamatergic synapse	PPP3CB;PLCB2;PPP3R1;GNG7;GRM4;TRPC1;SLC1A3;PLA2G4D;GRIN2C
Cholinergic synapse	PRKCG;GNAI1;KCNQ1;MAPK3;PRKACB;PLCB2;KRAS;PRKACG;KCNJ12
Serotonergic synapse	ITPR1;HTR1A;GNAS;GNG13;HTR3B;CYP2C39;GNG12;CYP2C54;PRKCA
GABAergic synapse	GNB2;GABRA1;GNG13;SLC38A3;GLUL;PRKCB;GABRR3;GABRB2;GNAI2
Dopaminergic synapse	CREB3L2;CAMK2G;GNG4;GNAQ;CREB3L1;GNG11;MAPK8;GNB1;GNG2
Alcoholism	DRD1;HDAC7A;HIST2H4;HIST1H3A;HIST1H2BH;SLC29A1;PPP1CA;RAF1;HIST3H2BB
Pathways in cancer	BDKRB1;TGFB2;NKX3-1;BDKRB2;FGF9;Shh;PRKACB;TPM3;GNA12

GNB2 has several biochemical functions, for example, GTPase activity, GTPase binding, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2 itself. We selected most functions GNB2 had, and list some proteins which have the same functions with GNB2. You can find most of the proteins on our site.

Function	Related Protein
GTPase activity	GNAI2B;RAB33A;RAB7;RAB31;ARL1;RAB34;MX1;TUFM;TUBA1C
GTPase binding	IARS;GNB3;GOLGA4;YBX1;EPRS;VPS41;RASA1;GNB1;BNIP3
calcium channel regulator activity	GRM7;SGK2B;TMEM110;SGK1;STIM1B;STIM2;CACNA2D1A;STIM1;GRM2
protein binding	ITGB5;ADRB1;PSENEN;Car8;SILV;RNASEL;DDIT3;ZNF576;ALDOC
protein complex binding	TRAF2;NFYB;ST13;NDUFA4;SIX2;DRD1A;PDX1;HNF1B;TAB1
signal transducer activity	BMX;TAAR13B;GNG8;PRKCE;GNAQ;PTGER2B;VMN1R50;OLFR186;MC5RB

GNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2.

Cdk1; Cbx1; Cep76; IKBKE; USP50; Trim69; Haus4; Haus1; MAP3K3; Mau2; TRAF6; RIPK3; CAPNS1; TFAP2A; PDHB; RCC1; ANXA7; GADD45A; CDKN1A; STAT5A

Xing, T; Higgins, VJ; et al. Identification of G proteins mediating fungal elicitor-induced dephosphorylation of host plasma membrane H+-ATPase. JOURNAL OF EXPERIMENTAL BOTANY 48:229-237(1997).

Joshi, S; Abebe, W; et al. G-proteins in guinea pig airway smooth muscle: Identification and functional involvement. PHARMACOLOGICAL RESEARCH 33:195-202(1996).

LIU, JJ; MCLENNAN, AG; et al. PURIFICATION AND PROPERTIES OF GTP-GTP GUANYLYLTRANSFERASE FROM ENCYSTED EMBRYOS OF THE BRINE SHRIMP ARTEMIA. JOURNAL OF BIOLOGICAL CHEMISTRY 269:11787-11794(1994).