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GNB5

  • Official Full Name

    guanine nucleotide binding protein (G protein), beta 5

  • Overview

    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
  • Synonyms

    GNB5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide-binding protein subunit beta-5; GB5; FLJ37457; FLJ43714; G protein beta 5 subunit; G protein beta subunit 5L; GB 5; GBB5_HUMAN; Gbeta5; GNB 5; Guanine nucleotide binding protein (G protein) beta 5; Guanine nucleotide binding protein beta 5; Guanine nucleotide binding protein beta 5 subunit; Guanine nucleotide binding protein beta subunit 5L; Guanine nucleotide binding protein subunit beta 5; Transducin beta chain 5; OTTHUMP00000162718; G protein, beta-5 subunit; G protein, beta subunit 5L; guanine nucleotide-binding protein, beta subunit 5L;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNB5-29091TH Recombinant Human GNB5, His-tagged E.coli His
Human GNB5-13358H Recombinant Human GNB5, GST-tagged E.coli GST 42-140a.a.
Human GNB5-5859HCL Recombinant Human GNB5 293 Cell Lysate HEK293 N/A
Human GNB5-5058H Recombinant Human GNB5 Protein, GST-tagged Wheat Germ GST
Human GNB5-2978H Recombinant Human GNB5 protein, His-SUMO-tagged E.coli His-SUMO 1-353aa
Human GNB5-5372HF Recombinant Full Length Human GNB5 Protein, GST-tagged In Vitro Cell Free System GST 126 amino acids
Mouse GNB5-7031M Recombinant Mouse GNB5 Protein Mammalian Cell His
Mouse GNB5-3769M Recombinant Mouse GNB5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNB5-3769M-B Recombinant Mouse GNB5 Protein Pre-coupled Magnetic Beads HEK293
Rat GNB5-2604R Recombinant Rat GNB5 Protein Mammalian Cell His
Rat GNB5-2259R-B Recombinant Rat GNB5 Protein Pre-coupled Magnetic Beads HEK293
Rat GNB5-2259R Recombinant Rat GNB5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GNB5-5563C Recombinant Chicken GNB5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GNB5 Related Articles

GNB5 involved in several pathways and played different roles in them. We selected most pathways GNB5 participated on our site, such as ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of Kainate Receptors upon glutamate binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ADP signalling through P2Y purinoceptor 1MAPK14;GNB5
ADP signalling through P2Y purinoceptor 12
Activation of Kainate Receptors upon glutamate bindingNCALDA;DLG3;DLG4;GNB5;DLG1L
Adrenaline,noradrenaline inhibits insulin secretionADRA2A;ADCY6;GNB5;GNB5A;ADRA2C;GNB3B;GNB3A;GNB5B
AlcoholismHIST1H3A;ADORA2B;HIST1H3E;HDAC11;HIST1H2BN;GNG13;HIST2H3C2;SLC29A1;GM14477
Aquaporin-mediated transportAQP9B;MIP;AQP1A.1;AQP8A.1;ADCY8;ADCY9;ADCY3;AQP1A.2;ADCY7
Beta-catenin independent WNT signalingCLTB;DVL3;PRICKLE1B;PRICKLE1;DVL2;MOV10;CLTA;AP2B1;ITPR2
Ca2+ pathwayAGO2;AGO1;GNB5;MOV10;AGO3

GNB5 has several biochemical functions, for example, G-protein gamma-subunit binding, GTPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB5 itself. We selected most functions GNB5 had, and list some proteins which have the same functions with GNB5. You can find most of the proteins on our site.

Function Related Protein
G-protein gamma-subunit binding
GTPase activityRND2;TUBAL3;TUBA8;DDX3X;RAB25A;TUBB4B;ARF3;ARF6;GNAO1A
chaperone bindingPARK2;HLA-B;SDF2L1;CDC37L1;H2-KE2;DNAJA1;TFRC;AHSA2;TIMM10
protein bindingMAGEA11;PI4KB;TRAF6;KIAA0947;GTF2B;PRDX1;ITGAL;TLK2;RFX6
signal transducer activityDRD2L;GRM8B;VMN1R49;CHRM2A;STAT5A;CRKL;ADORA2AB;OLFCQ19;OLFCG4

GNB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB5.

a8k1f4_human; GNG7; STIP1; MLF1; PSMD2; Usp19; HSP90AB1; q96be0_human; PFDN5; DNAJC7; AARSD1; PFDN2; NUDC; PSD; BNIP3L; EIF3J; OLFM2; ANXA7; RPA1; CDKN1A

Fang, LT; Lee, S; et al. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. INTERNATIONAL JOURNAL OF ONCOLOGY 44:211-221(2014).
Chen, YY; Zhou, CX; et al. Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 385:797-806(2012).
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