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GNG3

Official Full Name

guanine nucleotide binding protein (G protein), gamma 3
Overview

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004
Synonyms

GNG3; guanine nucleotide binding protein (G protein), gamma 3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; guanine nucleotide binding protein gamma 3 subunit; NBP gamma 3; GBG3_HUMAN; Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-3 subunit; NBP gamma-3; OTTHUMP00000236158; guanine nucleotide-binding protein gamma-3 subunit;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNG3-28960TH	Recombinant Human GNG3	Wheat Germ	N/A	75 amino acids	Inquiry
Human	GNG3-5852HCL	Recombinant Human GNG3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNG3-5069H	Recombinant Human GNG3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GNG3-5388HF	Recombinant Full Length Human GNG3 Protein, GST-tagged	In Vitro Cell Free System	GST	75 amino acids	Inquiry
Human	GNG3-301307H	Recombinant Human GNG3 protein, GST-tagged	E.coli	GST	Met1-Thr60	Inquiry
Human	GNG3-216HF	Recombinant Full Length Human GNG3 Protein	In Vitro Cell Free System		75 amino acids	Inquiry
Mouse	GNG3-7037M	Recombinant Mouse GNG3 Protein	Mammalian Cell	His		Inquiry
Mouse	GNG3-3774M-B	Recombinant Mouse GNG3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GNG3-3774M	Recombinant Mouse GNG3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GNG3-1905R	Recombinant Rhesus monkey GNG3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GNG3-1725R	Recombinant Rhesus Macaque GNG3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GNG3-1725R-B	Recombinant Rhesus Macaque GNG3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GNG3-9348Z	Recombinant Zebrafish GNG3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GNG3 Related Articles

GNG3 involved in several pathways and played different roles in them. We selected most pathways GNG3 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	ETS2;LAT;KSR2;FGF7;VEGFC;PLCG1;FGF5;PLA2G5;FOXO4
Chemokine signaling pathway	GNG4;AKT2;Ccl12;CCL28;LOC100033925;RASGRP2;BRAF;DOCK2;AKT1
PIK-Akt signaling pathway	FGF4;IL6R;OSMR;PDGFD;TCL1B;BAD;TCL1;FGF1;LAMC2
Circadian entrainment	NOS1;MAPK3;GNAS;GRIA1;GNB1;CACNA1H;KCNJ9;KCNJ5;FOS
Retrograde endocannabinoid signaling	GABRQ;GNG7;MAPK1;SLC17A7;GABRE;ITPR3;ITPR1;PRKACB;NAPEPLD
Glutamatergic synapse	ITPR3;GNAS;GNB1;PLA2G4A;GRM4;PPP3CA;PPP3R1;DLGAP1;PLD2
Cholinergic synapse	ITPR3;PIK3CD;CREB3L3;GNG5;ACHE;PIK3R3;CREB3L2;FYN;KCNJ3
Serotonergic synapse	CYP2D26;HTR2C;RAF1;PRKCB;HTR6;PTGS2;ALOX8;GNG2;MAP2K1
GABAergic synapse	SLC12A5;GABBR2;GLS2;GNG2;GABRG3;GNB2;GNB3;GNG10;GABRR2
Dopaminergic synapse	MAPK9;MAPK11;GNB4;GNG13;SLC18A1;PLCB2;DRD3;GNAQ;ARNTL
Taste transduction	TAS2R107;TAS2R136;SCNN1B;PRKACA;TAS2R109;TAS2R117;PRKACB;TAS2R137;TAS2R143
Alcoholism	HDAC6;HIST2H3C1;HDAC8;HIST1H4M;GNAO1;GM14476;GRIN3B;GNB1;H3F3C
Pathways in cancer	CBLB;HHIP;TRAF6;SMAD3;RALBP1;RB1;FGF18;AGTR1A;ITGA6

GNG3 has several biochemical functions, for example, GTPase activity, signal transducer activity, type 1 angiotensin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNG3 itself. We selected most functions GNG3 had, and list some proteins which have the same functions with GNG3. You can find most of the proteins on our site.

Function	Related Protein
GTPase activity	GNA11B;RAB4B;ARL1;RAB17;RAB18B;ARHGAP5;RAB33B;RAC3;TUBB6
signal transducer activity	PTK2;PTGER1C;SLC35B2;ECT2;TAAR14L;PTK2B;PTH1RB;OPN4XB;CTNNB1
type 1 angiotensin receptor binding	GNA13B;GNB1;ARRB2;GNG3;GNA13;TYK2;BDKRB2;GNA13A;ARAP1

GNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNG3.

GNAI3; SNAP23

Gonzalez-Yanes, C; Santos-Alvarez, J; et al. Pancreastatin, a chromogranin A-derived peptide, activates G alpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat heart membranes. CELLULAR SIGNALLING 13:43-49(2001).

Panchalingam, S; Undie, AS; et al. Optimized binding of [S-35]GTP gamma S to Gq-like proteins stimulated with dopamine D-1-like receptor agonists. NEUROCHEMICAL RESEARCH 25:759-767(2000).