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GP9

  • Official Full Name

    glycoprotein IX (platelet)

  • Overview

    This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
  • Synonyms

    GPIX; CD42a; GP9 platelet glycoprotein IX; GP-IX; glycoprotein 9; OTTHUMP00000217111;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GP9-26632TH Recombinant Human GP9 Wheat Germ N/A 177 amino acids
Human GP9-7219H Recombinant Human GP9, His-tagged E.coli His 17-147aa
Human GP9-5820HCL Recombinant Human GP9 293 Cell Lysate HEK293 N/A
Human GP9-5133H Recombinant Human GP9 Protein, GST-tagged Wheat Germ GST
Human GP9-205HF Recombinant Full Length Human GP9 Protein In Vitro Cell Free System 177 amino acids
Human GP9-823H Recombinant Human GP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GP9-5466HF Recombinant Full Length Human GP9 Protein, GST-tagged In Vitro Cell Free System GST 177 amino acids
Human GP9-2342H Recombinant Human GP9 Protein (Thr17-Gly147), His tagged E.coli His Thr17-Gly147
Human GP9-4208H Recombinant Human GP9 Protein (Met1-Gly147), C-His tagged Mammalian cells C-His Met1-Gly147
Mouse GP9-7085M Recombinant Mouse GP9 Protein Mammalian Cell His
Mouse GP9-3810M Recombinant Mouse GP9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gp9-3279M Recombinant Mouse Gp9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GP9-3810M-B Recombinant Mouse GP9 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL10221HF Recombinant Full Length Human Platelet Glycoprotein Ix(Gp9) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-177)
Mus musculus (Mouse) RFL23623MF Recombinant Full Length Mouse Platelet Glycoprotein Ix(Gp9) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-177)
Rhesus Macaque GP9-1925R Recombinant Rhesus monkey GP9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GP9-1745R Recombinant Rhesus Macaque GP9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GP9-1745R-B Recombinant Rhesus Macaque GP9 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GP9 Related Articles
  • GP9 Related Research Area

GP9 involved in several pathways and played different roles in them. We selected most pathways GP9 participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionITGA1;SV2B;COL4A6;COL11A1A;Reln;COL1A1;COL6A2;LAMC1;TNC
Platelet activationRAP1B;NOS3;F2RL3;PTGIR;PIK3R1;ROCK2;PLA2G4A;Adcy4;LCP2
Hematopoietic cell lineageIL1R1;ITGA5;CD44;KITLG;CD8A;GP1BB;GM-CSF;CD34;IL11RA

GP9 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GP9 itself. We selected most functions GP9 had, and list some proteins which have the same functions with GP9. You can find most of the proteins on our site.

Function Related Protein
protein bindingRASSF4;BUB3;PEX13;IL17F;ZFP523;FAM9B;BAZ1B;SENP7;TEK

GP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of GP9.

SPRY2; GP1BA; HOXA1; GP5; APPBP2; CRK; Hoxa1; GP1BB

Bragadottir, G; Birgisdottir, ER; et al. Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome-A case control study. AMERICAN JOURNAL OF HEMATOLOGY 90:149-155(2015).
Hassapis, KA; Stylianou, DC; et al. Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines. VIRUSES-BASEL 6:5047-5076(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the impact of altered GP9 expression on cardiovascular health? 01/09/2022

Altered GP9 expression can impact blood clotting, affecting cardiovascular health.

How does GP9 contribute to the formation of platelet plugs during wound healing? 08/16/2021

It facilitates the formation of platelet plugs at injury sites, crucial for wound healing.

What role does GP9 play in thrombotic disorders? 05/11/2020

Abnormalities in GP9 can lead to thrombotic disorders due to altered platelet function.

How do genetic variations in the GP9 gene affect platelet function and risk of bleeding disorders? 09/12/2019

Mutations in GP9 may result in impaired platelet adhesion, increasing the risk of bleeding disorders.

What potential therapeutic applications could arise from targeting GP9 in blood clotting disorders? 06/09/2019

Targeting GP9 could offer new treatments for managing clotting disorders and preventing thrombosis.

What is the primary role of GP9 in platelet function and blood coagulation? 05/05/2017

GP9 is essential for platelet adhesion, a critical step in blood clot formation.

How does GP9 interact with other components of the hemostatic system? 03/29/2017

GP9 works with other platelet surface proteins to initiate the clotting cascade.

Customer Reviews (3)

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Reviews
02/18/2021

    Streamlines experiments. Saves time and effort.

    12/29/2019

      Accurate data for credibility. Aids our research significantly.

      05/04/2017

        Exceptional expertise. Elevates our research outcomes.

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