GPD1
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Official Full Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
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Overview
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] -
Synonyms
GPD1; glycerol-3-phosphate dehydrogenase 1 (soluble); GPD-C; HTGTI; GPDH-C; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GPD1 Related Articles
GPD1 involved in several pathways and played different roles in them. We selected most pathways GPD1 participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PPAP2B;CEPT1;PLA2G2A;STIL;PTDSS1;EPT1;AGXT2L1;PLD2;MBOAT2B |
GPD1 has several biochemical functions, for example, NAD binding, glycerol-3-phosphate dehydrogenase [NAD+] activity, glycerol-3-phosphate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPD1 itself. We selected most functions GPD1 had, and list some proteins which have the same functions with GPD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | HIBADHA;GRHPR;ME3;CTBP2L;AHCY;GRHPRA;NNT;HIBADH;HSD3B4 |
| glycerol-3-phosphate dehydrogenase [NAD+] activity | GPD1C;GPD1A;GPD1B;TESCA;GPD1;GPD1L |
| glycerol-3-phosphate dehydrogenase activity | GPD2;GPD1 |
| oxidoreductase activity | HMGCRA;ALOX5B.2;CYP2K18;SNCA;AIFM4;DHRS13B;CYP2K22;RNLS;AOC1 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HMGCRA;MDH1AA;CTBP2L;LDHBB;CTBP2A;CTBP1;GPD1A;HSD3B5;SDR42E1 |
| protein homodimerization activity | NOS1;UGT1A6;GCA;KLHL7;PDGFC;HEXB;KIAA1804;HSF2;NOS2 |
GPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPD1.
Ywhae; Ywhaz; Kcnma1; Hsd3b4; Dlg4; Pgls; Hsd3b7
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