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GPR143

  • Official Full Name

    G protein-coupled receptor 143

  • Overview

    This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.
  • Synonyms

    GPR143; G protein-coupled receptor 143; OA1, ocular albinism 1 (Nettleship Falls); G-protein coupled receptor 143; ocular albinism 1 (Nettleship Falls); ALBINISM OCULAR TYPE I; G protein coupled receptor 143; GP143_HUMAN; MOA1; NETTLESHIP FALLS TYPE OCULAR ALBINISM; Ocular albinism type 1 protein; Ocular albinism type 1 protein homolog; Ocular albinism1 Nettleship Falls type; OA1; NYS6;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPR143-739HCL Recombinant Human GPR143 cell lysate N/A
Human GPR143-5189H Recombinant Human GPR143 Protein, GST-tagged Wheat Germ GST
Human GPR143-5188H Recombinant Human GPR143 Protein Wheat Germ N/A
Human GPR143-5640HF Recombinant Full Length Human GPR143 Protein, GST-tagged In Vitro Cell Free System GST 424 amino acids
Human GPR143-5639HF Recombinant Full Length Human GPR143 Protein In Vitro Cell Free System 693 amino acids
Mouse GPR143-7148M Recombinant Mouse GPR143 Protein Mammalian Cell His
Mouse GPR143-3853M Recombinant Mouse GPR143 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GPR143-3853M-B Recombinant Mouse GPR143 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL26150HF Recombinant Full Length Human G-Protein Coupled Receptor 143(Gpr143) Protein, His-Tagged E.coli expression system His Full Length (1-404)
Mus musculus (Mouse) RFL35466MF Recombinant Full Length Mouse G-Protein Coupled Receptor 143(Gpr143) Protein, His-Tagged E.coli expression system His Full Length (1-405)
Zebrafish GPR143-11078Z Recombinant Zebrafish GPR143 Mammalian Cell His
Chicken GPR143-5107C Recombinant Chicken GPR143 Mammalian Cell His
Kit-1287 GPR143 CHO-K1 β-Arrestin Orphan GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GPR143 involved in several pathways and played different roles in them. We selected most pathways GPR143 participated on our site, such as GPCRs, Other, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR143 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GPCRs, OtherGPR143;CELSR2;CELSR1;S1PR1;VN1R1;GPR61;PROKR2;GPR116;SETD6

GPR143 has several biochemical functions, for example, G-protein coupled receptor activity, L-DOPA binding, L-DOPA receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR143 itself. We selected most functions GPR143 had, and list some proteins which have the same functions with GPR143. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityMTNR1BB;GPR81;GPR22;OLFR998;OR52B4;HTR5AL;TAAR19P;GPR27;CHRM5A
L-DOPA binding
L-DOPA receptor activity
dopamine bindingDRD4;DRD1;GPR143;TH;DRD2A;DRD2;DRD1A;DRD2B;DRD5
protein bindingMUC7;NUBP1;UFL1;AGL;CXCR7;TGFB2;SUZ12;C1orf216;RASL10B
tyrosine bindingYARS2;ORA1;GPR143

GPR143 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR143 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR143.

MLANA

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