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GPR161

Official Full Name

G protein-coupled receptor 161
Overview

Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM;139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell.;Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 (PubMed 18250320)).
Synonyms

GPR161; G protein-coupled receptor 161; G-protein coupled receptor 161; RE2; G protein coupled receptor 161; G protein coupled receptor RE2; OTTHUMP00000032586; OTTHUMP00000032587; G-protein coupled receptor RE2;

Type

Recombinant Proteins

Species

Bos taurus (Bovine)
Danio rerio (Zebrafish) (Brachydanio rerio)
Homo sapiens (Human)
Human
Mus musculus (Mouse)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Zebrafish

Source

E.coli
E.coli expression system
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GPR161-5204H	Recombinant Human GPR161 Protein	Wheat Germ	N/A		Inquiry
Human	GPR161-3869H	Recombinant Human GPR161 protein, His-tagged	E.coli	His	321-529 aa	$319 / 25ug
Human	GPR161-1201H	Recombinant Human GPR161 Protein (1-28 aa), GST-tagged	E.coli	GST	1-28 aa	Inquiry
Human	GPR161-5205H	Recombinant Human GPR161 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GPR161-5471HF	Recombinant Full Length Human GPR161 Protein	In Vitro Cell Free System		212 amino acids	Inquiry
Bos taurus (Bovine)	RFL12413BF	Recombinant Full Length Bovine G Protein-Coupled Receptor 161(Gpr161) Protein, His-Tagged	E.coli expression system	His	Full Length (1-528)	Inquiry
Danio rerio (Zebrafish) (Brachydanio rerio)	RFL13469DF	Recombinant Full Length Danio Rerio G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged	E.coli expression system	His	Full Length (1-526)	Inquiry
Homo sapiens (Human)	RFL12517HF	Recombinant Full Length Human G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged	E.coli expression system	His	Full Length (1-529)	Inquiry
Mus musculus (Mouse)	RFL22940MF	Recombinant Full Length Mouse G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged	E.coli expression system	His	Full Length (1-545)	Inquiry
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	RFL7054XF	Recombinant Full Length Xenopus Tropicalis G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged	E.coli expression system	His	Full Length (1-518)	Inquiry
Zebrafish	GPR161-1665Z	Recombinant Zebrafish GPR161	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GPR161 Related Articles
GPR161 Related Research Area

GPR161 involved in several pathways and played different roles in them. We selected most pathways GPR161 participated on our site, such as Hedgehog off state, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR161 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog off state	TTC21B;IFT122;TULP3;IFT172;WDR19;BBS13;RPGRIP1L;INTU;GPR161
Hedgehog on state	CDC73;IFT172;GAS8;CDON;BOC;DZIP1;GPR161;KIF7;SPOP
Signal Transduction	GPR177;MAPK6;SOX7;RSPO4;PLEKHG2;OR52J3;PDK2B;NF2A;USP15
Signaling by Hedgehog	HHAT;SCUBE2;CDC73;SPOPL;RPGRIP1L;SPOP;INTU;NOTUM;DZIP1

GPR161 has several biochemical functions, for example, G-protein coupled amine receptor activity, G-protein coupled receptor activity, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR161 itself. We selected most functions GPR161 had, and list some proteins which have the same functions with GPR161. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled amine receptor activity	TAAR7D;DRD1A;DRD4A;TAAR13C;TAAR7B;GPR161;TAAR4;GPR21;DRD1B
G-protein coupled receptor activity	OLFR474;HCAR3;TAS2R125;PROKR2;NPFFR1L3;TAS2R20;OPN1MW2;GPR25;DRD7
signal transducer activity	FAS;TSPAN6;CCR12A;NFKBIB;RGS9B;CALCRLA;GNAO1A;S100A9;ACKR3B

GPR161 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR161 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR161.

Feigin, ME; Xue, B; et al. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4191-4196(2014).

Laffray, S; Bouali-Benazzouz, R; et al. Impairment of GABAB receptor dimer by endogenous 14-3-3 zeta in chronic pain conditions. EMBO JOURNAL 31:3239-3251(2012).

Hedgehog Family