GPX4
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Official Full Name
glutathione peroxidase 4
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Overview
This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
GPX4; glutathione peroxidase 4; MCSP; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxidase; sperm nucleus glutathione peroxidase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Pongo Pygmaeus
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- His|T7
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
GPX4 involved in several pathways and played different roles in them. We selected most pathways GPX4 participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GSTM1;GGT1;TXNDC12;MGST1.2;GSTM7;PGD;GSTT1;OPLAH;LAP3 |
GPX4 has several biochemical functions, for example, glutathione peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX4 itself. We selected most functions GPX4 had, and list some proteins which have the same functions with GPX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione peroxidase activity | MGST2;GSTZ1;GPX4A;GPX6;MGST1;GPX5;GPX1A;GPX1B;PRDX6 |
| phospholipid-hydroperoxide glutathione peroxidase activity | GPX4;GPX1 |
GPX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX4.
OTUD5; MAPK13; PRDX6
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, research suggests that GPX4 modulation may have therapeutic potential in neurodegenerative diseases like Alzheimer's and Parkinson's.
Research is exploring the potential of GPX4 as a biomarker for diseases associated with oxidative stress, such as neurodegenerative disorders and certain cancers.
Certain dietary components, such as selenium, can influence GPX4 activity. Selenium is a cofactor for GPX4 and is obtained through the diet.
GPX4 contributes to cardiovascular health by protecting cells from oxidative stress, which is implicated in the development of cardiovascular diseases.
Yes, some compounds targeting GPX4 are being investigated in preclinical and early clinical trials for various diseases, including cancer.
Customer Reviews (3)
Write a reviewThe manufacturer's excellent technical support, commitment to innovation, and customer-centric approach position them as an invaluable resource.
Its high level of consistency allows for precise measurements and accurate data interpretation, enhancing the reliability of my findings.
the GPX4 protein is of exceptional quality, perfectly suiting my experimental needs.
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