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GRIK3

Official Full Name

glutamate receptor, ionotropic, kainate 3
Overview

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
Synonyms

GRIK3; glutamate receptor, ionotropic, kainate 3; glutamate receptor, ionotropic kainate 3; GLUR7; EAA5; Excitatory amino acid receptor 5; GLR 7; GLR7; GLU R7; GLUR 7; GluR 7a; GluR7a; Glutamate receptor 7; Glutamate receptor ionotropic kainate 3; GRIK 3; gluR-7; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7));

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRIK3-5338H	Recombinant Human GRIK3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRIK3-5644HF	Recombinant Full Length Human GRIK3 Protein, GST-tagged	In Vitro Cell Free System	GST	919 amino acids	Inquiry
Mouse	GRIK3-7266M	Recombinant Mouse GRIK3 Protein	Mammalian Cell	His		Inquiry
Mouse	GRIK3-3928M-B	Recombinant Mouse GRIK3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GRIK3-3928M	Recombinant Mouse GRIK3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRIK3-2697R	Recombinant Rat GRIK3 Protein	Mammalian Cell	His		Inquiry
Rat	GRIK3-2351R	Recombinant Rat GRIK3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRIK3-2351R-B	Recombinant Rat GRIK3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GRIK3 Related Articles

GRIK3 involved in several pathways and played different roles in them. We selected most pathways GRIK3 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neuroactive ligand-receptor interaction	NPFFR2;CNR1;GRIA1B;NTSR1;TAAR12E;TACR1B;PTGER2B;GALR1;NTSR2
Glutamatergic synapse	GNAI3;GNAQ;GNG2;GRIA3;MAPK3;GRM3;PRKCA;GNG13;HOMER3

GRIK3 has several biochemical functions, for example, adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, extracellular-glutamate-gated ion channel activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK3 itself. We selected most functions GRIK3 had, and list some proteins which have the same functions with GRIK3. You can find most of the proteins on our site.

Function	Related Protein
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
extracellular-glutamate-gated ion channel activity	GRIN1B;GRIN3B;GRIN2D;GRID1;GRIK2;GRIK4;GRIA2B;GRIA3B;GRIK3
glutamate receptor activity	GRM6;GRM7;GRM3;GRID2;GRM8;GRIK3;GRM4;GRM1;GRIA1
ion channel activity	FXYD6;CACNA1DA;CHRNB3A;KCNC2;KCNV2;CACNA1BA;GRIN3B;FXYD2;CACNA1SB
ionotropic glutamate receptor activity	GRIA3A;GRIA1A;GRIA4;GRIN3B;GRIA4A;GRIK3;GRID2;GRIN1B;GRID1
kainate selective glutamate receptor activity	GRIK2;GRIK5;GRIK4;GRIK3;GRIK1
protein binding	ADCYAP1R1;DIRAS3;TUBA4A;IFRD2;AGFG1;HSPA8;GNG10;MSTN;REEP6
receptor activity	MRC1;VAC14;LILRB3;ITGB8;KIR2DL3;TNFRSF25;IL10RA;ITGB1B.1;CD93

GRIK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK3.

Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).

Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).