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GRIK4

Official Full Name

glutamate receptor, ionotropic, kainate 4
Overview

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
Synonyms

GRIK4; glutamate receptor, ionotropic, kainate 4; GRIK; glutamate receptor, ionotropic kainate 4; GluK4; KA1; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1; EAA1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRIK4-29879TH	Recombinant Human GRIK4	Wheat Germ	N/A	110 amino acids	Inquiry
Human	GRIK4-5340H	Recombinant Human GRIK4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	GRIK4-7267M	Recombinant Mouse GRIK4 Protein	Mammalian Cell	His		Inquiry
Mouse	GRIK4-3929M-B	Recombinant Mouse GRIK4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GRIK4-3929M	Recombinant Mouse GRIK4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRIK4-2698R	Recombinant Rat GRIK4 Protein	Mammalian Cell	His		Inquiry
Rat	GRIK4-2352R	Recombinant Rat GRIK4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRIK4-2352R-B	Recombinant Rat GRIK4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GRIK4 Related Articles

GRIK4 involved in several pathways and played different roles in them. We selected most pathways GRIK4 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neuroactive ligand-receptor interaction	APLNRA;CHRNA7;F2RL1;PRL;TACR1;MC4R;KISS1RB;NPY5R;DRD7
Glutamatergic synapse	GRM4;GNB4;GNG4;GNAI2;DLGAP1;GNB3;GNAO1;GRIK4;GRIK5

GRIK4 has several biochemical functions, for example, extracellular-glutamate-gated ion channel activity, kainate selective glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK4 itself. We selected most functions GRIK4 had, and list some proteins which have the same functions with GRIK4. You can find most of the proteins on our site.

Function	Related Protein
extracellular-glutamate-gated ion channel activity	GRIN2B;GRID1;GRIA4A;GRIA1;GRIK2;GRIA2;GRIA4B;GRIK4;GRIN2A
kainate selective glutamate receptor activity	GRIK3;GRIK1;GRIK2;GRIK5;GRIK4

GRIK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK4.

Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).

Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).