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GRIN2B

Official Full Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Overview

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Synonyms

GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; MRD6; NR2B; hNR3; GluN2B; NMDAR2B; glutamate receptor ionotropic, NMDA 2B; NR3; glutamate receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E. coli
E.coli
HEK293
Mammalian Cell
Protein Conjugation
Wheat Germ

Tag

C
His
GST
His (Fc)
Avi
His|GST
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRIN2B-29049TH	Recombinant Human GRIN2B	Wheat Germ	N/A	110 amino acids	Inquiry
Human	GRIN2B-13535H	Recombinant Human GRIN2B, His-tagged	E.coli	His	C-term-352a.a.	$319 / 25ug
Human	GRIN2B-1354H	Recombinant Human GRIN2B protein, His & GST-tagged	E.coli	His/GST	Ile35~Asp557	Inquiry
Human	GRIN2B-2848H	Recombinant Human GRIN2B protein(1251-1380 aa), C-His-tagged	E. coli	C-His	1251-1380 aa	Inquiry
Human	GRIN2B-1915H	Recombinant Human GRIN2B protein, His-tagged	HEK293	His	Arg 27 - Met 394	Inquiry
Human	GRIN2B-5345H	Recombinant Human GRIN2B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRIN2B-2546H	Recombinant Human GRIN2B Protein (Tyr1133-Val1484), N-His tagged	E.coli	N-His	Tyr1133-Val1484	Inquiry
Rat	GRIN2B-2701R	Recombinant Rat GRIN2B Protein	Mammalian Cell	His		Inquiry
Rat	Grin2b-2814R	Recombinant Rat Grin2b Protein, His-tagged, OVA Conjugated	Protein Conjugation	N-His	Pro1113-Cys1122	Inquiry
Rat	GRIN2B-2355R-B	Recombinant Rat GRIN2B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GRIN2B-2355R	Recombinant Rat GRIN2B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

GRIN2B involved in several pathways and played different roles in them. We selected most pathways GRIN2B participated on our site, such as Ras signaling pathway, Rap signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	MAPK3;IKBKB;KITLG;GNG3;MAP2K1;PAK3;CALM3;INSR;PLA2G2A
Rap signaling pathway	LCP2;FGF6;RAC2;ITGB3;RRAS;KIT;ID1;RAP1GAP;FGF11
cAMP signaling pathway	PDE4D;PLD1;SOX9;HCAR3;ATP1B1;SLC9A1;BAD;RAC1;PIK3CB
Neuroactive ligand-receptor interaction	NTSR2;PTGER4;UTS2R;GLRB;OPRK1;F2RL3;ADRB3A;GRIK5;CHRNA4B
Circadian entrainment	GNG3;GNG2;GRIA3;PLCB3;PRKCG;CACNA1H;PER1;ADCYAP1R1;GNAI3
Long-term potentiation	RPS6KA1;RPS6KA2;PPP1R1A;MAPK3;CAMK2A;PPP3CB;CALML5;CAMK2D;PLCB2
Glutamatergic synapse	PLA2G4A;PRKACA;GNAI1;GLS;GRIN2B;PPP3CA;GRIA1;GRM3;GNG12
Dopaminergic synapse	GNG4;KCNJ6;PPP2R1B;PPP1CC;GRIA2;PRKCG;KIF5C;ARNTL;CALM3
Alzheimers disease	PLCB1;NDUFC2-KCTD14;CALML3;PPP3CA;SDHD;APH1B;ATP5C1;ITPR1;EIF2AK3
Amyotrophic lateral sclerosis (ALS)	CCS;TRP53;MAPK11;TOMM40;GRIA2;GRIN2C;GPX1;MAP2K3;NEFH
Huntingtons disease	CREB3L1;NDUFB6;COX5A;DNALI1;NDUFS8;NDUFA2;VDAC1;HDAC2;NRF1
Cocaine addiction	CREB5;FOSB;GNAS;CREB3L3;PRKACG;PDYN;CDK5;DRD2;GRIN3B
Nicotine addiction	SLC17A6;GABRA4;GRIN2B;SLC17A8;GRIA2;GRIN2D;GRIN1;GABRE;GRIN3A
Alcoholism	HIST1H2BA;HIST2H2BE;HIST1H3G;HDAC4;HIST3H2BB;HDAC3;HIST3H3;HIST1H4D;GRIN3B
Systemic lupus erythematosus	H3F3C;HIST1H2AM;HIST1H2AE;HLA-DOA;C4A;HIST1H3I;HIST1H2AP;HIST1H2AA;H2AFB2

GRIN2B has several biochemical functions, for example, NMDA glutamate receptor activity, calcium channel activity, extracellular-glutamate-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2B itself. We selected most functions GRIN2B had, and list some proteins which have the same functions with GRIN2B. You can find most of the proteins on our site.

Function	Related Protein
NMDA glutamate receptor activity	GRIN3A;GRIN1A;GRIN2D;GRIN2A;GRIN1B;GRIN3B;GRIN2C;GRIN2B;GRIN2BB
calcium channel activity	TMEM37;CACNG2B;CACFD1;CACNB2;SLC24A5;CACNA1SB;CATSPER2;CACNA2D3;CACNG2A
extracellular-glutamate-gated ion channel activity	GRIA3A;GRIN1A;GRIN3A;GRIK1;GRIA1A;GRIN1B;GRIN2D;GRIA1;GRID2
glycine binding	GLRA4A;GRIN3A;GSS;SRR;SIX2A;ALAS2;GLRA4B;GRIN2B;GRIN3B
protein binding	CLSTN2;PEPD;TXLNB;UBASH3B;RNF10;PSMC5;RBM26;HNRNPD;TMEM218
zinc ion binding	VPS8;MT1H;THRA;SPRYD5;BIRC2;LMX1BB;ZNF259;GRIN2A;TRIM27

GRIN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2B.

CAMK2A; Dlg4; DLG4; Dlg3; PPP1CA; MAGI3; PTPRC; PTPRB; PTPRG; PPP3CA; PTPN12