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GRK1

Official Full Name

G protein-coupled receptor kinase 1
Overview

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Synonyms

GRK1; G protein-coupled receptor kinase 1; rhodopsin kinase , RHOK; rhodopsin kinase; GPRK1; RK; RHOK;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Human
Mouse
Rat

Source

HEK293
HEK293T
Mammalian Cell
Sf21
Sf9 Insect Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRK1-1409H	Active Recombinant Human GRK1, GST-tagged	Sf9 Insect Cell	GST	Full length	Inquiry
Human	GRK1-71HFL	Active Recombinant Full Length Human GRK1 Protein, N-His-tagged	Sf21	His	Full Length	Inquiry
Human	GRK1-27928TH	Recombinant Human GRK1	Sf9 Insect Cell	N/A	563 amino acids	Inquiry
Human	GRK1-1018H	Recombinant Human G Protein-Coupled Receptor Kinase 1, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	GRK1-5739HCL	Recombinant Human GRK1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GRK1-5352H	Recombinant Human GRK1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	Grk1-3311M	Recombinant Mouse Grk1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	GRK1-2710R	Recombinant Rat GRK1 Protein	Mammalian Cell	His		Inquiry
Rat	GRK1-2364R	Recombinant Rat GRK1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRK1-2364R-B	Recombinant Rat GRK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	GRK1-6261C	Recombinant Chicken GRK1	Mammalian Cell	His		Inquiry

GRK1 involved in several pathways and played different roles in them. We selected most pathways GRK1 participated on our site, such as Chemokine signaling pathway, Endocytosis, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chemokine signaling pathway	GNG12;CXCL8;IL-8;WASL;CCL15;Cxcl15;GNB2;RHOA;PXN
Endocytosis	ARPC5B;IL2RA;WWP1;PRKCZ;DDL-2;STAMBPA;IQSEC3;VPS4B;IGF1R
Phototransduction	RCV1;CALM1B;GUCA1B;SAG;CALM3A;GRK1;GNAT3;RCVRNA;RCVRN

GRK1 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK1 itself. We selected most functions GRK1 had, and list some proteins which have the same functions with GRK1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DGKB;TAP1;CSK;MSH3;PRKCBA;MOS;TARSL2;ACVR1;MYO5C
G-protein coupled receptor kinase activity	GRK1;GRK5;GRK6;GRK1A;GRK7B;GRK4;ADRBK2;GRK1B;RLN1
protein kinase activity	CDK14;Fert2;SRPK1;SGK2B;CDKL5;ERBB3B;GRK1B;GM711;PRPF4BA
rhodopsin kinase activity	GRK4;GRK1;RLN1;GRK7;GRK1A;GRK7A;GRK1B;GRK7B

GRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK1.

H2AFV

Osawa, S; Jo, R; et al. Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light. JOURNAL OF NEUROCHEMISTRY 107:1314-1324(2008).

Liu, P; Osawa, S; et al. M opsin phosphorylation in intact mammalian retinas. JOURNAL OF NEUROCHEMISTRY 93:135-144(2005).

GRKs (G Protein-coupled Receptor Kinases)