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GRK4

  • Official Full Name

    G protein-coupled receptor kinase 4

  • Overview

    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
  • Synonyms

    GRK4; G protein-coupled receptor kinase 4; G protein coupled receptor kinase 2 like (Drosophila) , GPRK2L; GPRK4; ITI1; IT11; GRK4a; GPRK2L;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • Tag
  • free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRK4-74HFL Active Recombinant Full Length Human GRK4 Protein, C-His-tagged Sf21 His Full Length
Human GRK4-5738HCL Recombinant Human GRK4 293 Cell Lysate HEK293 N/A
Human GRK4-5354H Recombinant Human GRK4 Protein, GST-tagged Wheat Germ GST
Human GRK4-2601H Recombinant Human GRK4 Protein (Ala187-Phe449), His tagged E.coli His Ala187-Phe449
Human GRK4-392H Recombinant Human GRK4 Protein, His-tagged E.coli His Phe187~Phe449
Human GRK4-5353H Active Recombinant Human GRK4 Protein Insect Cell N/A
Human GRK4-614H Recombinant Human GRK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GRK4-4746HF Active Recombinant Full Length Human GRK4 Protein Insect (sf21) Tag-free 1-578
Human GRK4-5545HF Recombinant Full Length Human GRK4 Protein, GST-tagged In Vitro Cell Free System GST 578 amino acids
Mouse GRK4-7280M Recombinant Mouse GRK4 Protein Mammalian Cell His
Mouse GRK4-3937M-B Recombinant Mouse GRK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse GRK4-3937M Recombinant Mouse GRK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Grk4-1050M Recombinant Mouse Grk4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat GRK4-2711R Recombinant Rat GRK4 Protein Mammalian Cell His
Rat GRK4-2365R Recombinant Rat GRK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRK4-2365R-B Recombinant Rat GRK4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GRK4-4942Z Recombinant Zebrafish GRK4 Mammalian Cell His
Chicken GRK4-1598C Recombinant Chicken GRK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRK4 Related Articles
  • GRK4 Related Signal Pathway

GRK4 involved in several pathways and played different roles in them. We selected most pathways GRK4 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayROCK1;CXCL2;VAV3;Ccl21c;Ccl12;SOS1;CCR3;CCL5;IKBKB
EndocytosisARRB1;EHD1;ITCH;BIN1;ASAP2B;GRK7A;RAB11FIP5;WASLA;SNX4

GRK4 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, rhodopsin kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK4 itself. We selected most functions GRK4 had, and list some proteins which have the same functions with GRK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCD2;PPP2R4;ATP7B;HSP90AA1.2;AACS;MAP3K8;ACVR2AA;MYO19;GALK2
G-protein coupled receptor kinase activityADRBK1;GRK7B;GRK1A;GRK7;RLN1;GRK6;GRK4;GRK5;GRK1B
rhodopsin kinase activityGRK1A;RLN1;GRK7;GRK7B;GRK7A;GRK4;GRK1B;GRK1

GRK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK4.

IKBKG; HSP90AB1

Furuya, Y; Araki, I; et al. Decreased expression of G protein-coupled receptor kinases in the detrusor smooth muscle of human urinary bladder with outlet obstruction. INTERNATIONAL JOURNAL OF UROLOGY 13:1226-1232(2006).
Fraga, S; Luo, YJ; et al. Dopamine D-1-like receptor-mediated inhibition of Cl-/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 18:347-360(2006).
  • Q&As
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