GSN
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Official Full Name
gelsolin
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Overview
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GSN; gelsolin; ADF; AGEL; brevin; actin-depolymerizing factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Cattle
- Chicken
- Human
- Mouse
- Porcine
- Rat
- Bovine Plasma
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Porcine Plasma
- Porcine smooth muscle
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- N
- 6×His
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- GSN Related Articles
- GSN Related Research Area
GSN involved in several pathways and played different roles in them. We selected most pathways GSN participated on our site, such as Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | LYN;MYO10;MARCKSL1;FCGR2A;PPAP2C;PRKCA;WASF2;cgr2b;ARPC1A |
| Regulation of actin cytoskeleton | ARHGAP35;PAK7;ARPC4L;MSNB;TMSB;PTK2;MYL9A;DIAPH3;FGF21 |
| Viral carcinogenesis | SND1;ACTN2;PSMC1;TP53;HIST1H4A;RBL2;H2BFWT;UBR4;PIK3R3 |
GSN has several biochemical functions, for example, actin binding, calcium ion binding, myosin II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSN itself. We selected most functions GSN had, and list some proteins which have the same functions with GSN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | MYOZ2;EPB41L2;MYH4;MYHC4;ACTN3;PHACTR4;AVIL;GSN;EPB41L1 |
| calcium ion binding | CUBN;S100T;HPGDS;EGFEM1;F7;SULF2;SPATA21;EFEMP1;EMR3 |
| myosin II binding | GCET2;GSN;GCSAM;TRIOBP |
| protein binding | ERAL1;PELI2;CCDC92;HSD3B7;GLA;DCPS;TNS4;C16orf5;ANXA2 |
| protein domain specific binding | OCLN;SKIL;HIST1H4D;HIST1H4F;TACC2;RHOA;CA;PLAUR;CENPJ |
GSN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSN here. Most of them are supplied by our site. Hope this information will be useful for your research of GSN.
ESR1; ARRB2; ARRB1; ESR2; act1; act-1; ACTA1; PPM1B; VDAC1; CASP4; TOM1L1; EGFR; q7arf1_yerpe
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