GSTO1
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Official Full Name
glutathione S-transferase omega 1
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Overview
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GSTO1; glutathione S-transferase omega 1; glutathione S-transferase omega-1; GSTTLp28; P28; AA407097; AI194287; AU018802; DKFZp686H13163; EC 2.5.1.18; Glutathione S transferase omega 1; Glutathione S-transferase omega 1-1; Glutathione S-transferase omega; Glutathione transferase omega 1; Glutathione-dependent dehydroascorbate reductase; Glutathione-S-transferase like; Glutathione-S-transferase omega 1; GSTO 1-1; GSTO1 1; GSTX; Gtsttl; MGC94845; OTTHUMP00000020429; GSTO-1; OTTHUMP00000020430; OTTHUMP00000020431;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- MYC
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
GSTO1 involved in several pathways and played different roles in them. We selected most pathways GSTO1 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | SMS;GSTA3;ANPEPB;MGST1;GSTT2B;GSTA;PGD;GSTA5;GGCTB |
| Metabolism of xenobiotics by cytochrome P | GSTM3;GSTM5;HSD11B1;GSTM7;CBR3;UGT2A1;UGT2B7;MGST1;CYP1A |
| Drug metabolism - cytochrome P | ALDH3B1;UGT1A9;AOX3;UGT1A2;GSTP2;GSTT1;MAOA;FMO2;GSTM3 |
| Chemical carcinogenesis | UGT1A6;GSTA2;CYP3A5;CYP3A4;CYP2E1;EPHX1;GSTK1;HSD11B1;CYP1B1 |
GSTO1 has several biochemical functions, for example, glutathione dehydrogenase (ascorbate) activity, glutathione transferase activity, methylarsonate reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTO1 itself. We selected most functions GSTO1 had, and list some proteins which have the same functions with GSTO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione dehydrogenase (ascorbate) activity | GSTO2;GSTO1 |
| glutathione transferase activity | GSTM7;GSTA4;MGST3;GSTO1;EEF1G;GSTM3;LTC4S;GSTK1;GSTA2 |
| methylarsonate reductase activity | GSTO2;GSTO1 |
| oxidoreductase activity | CYBASC3;CYP8B2;DHRS11B;VAT1L;GMPR2;CYP2AA12;CYP2N13;PHF2;RNLS |
| protein binding | GTF2H3;PXMP2;IPO5;TSGA10IP;PMEPA1;GTF3C3;DCAF11;ZNF670;CTSC |
GSTO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTO1.
HSPB1; UBA5; TRAF6; EEF1G; SETDB1; RBM48; KAT5; CEP126; FN1
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