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GUCY1A3

Official Full Name

guanylate cyclase 1, soluble, alpha 3
Overview

soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
Synonyms

GUCY1A3; guanylate cyclase 1, soluble, alpha 3; SGC; Gucy1a1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; soluble guanylate cyclase large subunit; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GUCY1A3-4489H	Recombinant Human GUCY1A3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GUCY1A3-627H	Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged	Sf9 Insect Cell	His		Inquiry
Human	GUCY1A3-5677HCL	Recombinant Human GUCY1A3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GUCY1A3-3345HF	Recombinant Full Length Human GUCY1A3 Protein, GST-tagged	In Vitro Cell Free System	GST	690 amino acids	Inquiry
Mouse	GUCY1A3-7388M	Recombinant Mouse GUCY1A3 Protein	Mammalian Cell	His		Inquiry
Mouse	GUCY1A3-4009M	Recombinant Mouse GUCY1A3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GUCY1A3-4009M-B	Recombinant Mouse GUCY1A3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GUCY1A3-2478Z	Recombinant Zebrafish GUCY1A3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GUCY1A3 Related Articles

GUCY1A3 involved in several pathways and played different roles in them. We selected most pathways GUCY1A3 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCY1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PDE7A;ADSL;PKLR;ZNRD1;PDE6G;POLR2GL;PDE3B;CECR1A;PDE6B
cGMP-PKG signaling pathway	IRS4;LOC100328615;PLCB1;ATF4;RGS2;PDE3B;GNA12;ITPR1;CREB3L2
Vascular smooth muscle contraction	PRKCBA;CALM3;MAP2K2;PPP1CA;PRKACAA;PLA2G4C;MAPK3;PRKACAB;CYP4A10
Gap junction	TUBA8L4;MAP2K1;TUBA1L2;MAP3K2;PRKACA;RAF1A;MAP2K5;PDGFAA;TUBA3A
Platelet activation	PPP1CC;PLA2G4F;COL24A1;NOS3;ITPR3;LYN;SRC;GUCY1A3;COL27A1
Circadian entrainment	GUCY1A3;GNAI1;CACNA1G;GNG13;GRIA2;ITPR1;GNB4;FOS;MAPK1
Long-term depression	GNAO1;GNAS;PRKCB;GNA13;GRIA3;PLA2G4A;GNAQ;PLA2G4F;GNAI3
Oxytocin signaling pathway	MEF2C;CAMKK2;PRKAB1;CAMK2G;CAMKK1;PRKAG1;PLCB3;ITPR3;PLCB2
Renin secretion	REN2;GNAS;PPP3R2;PPP3CA;CALM1;PRKACA;PDE3A;ACE;PDE3B
Salivary secretion	ATP1B2;PLCB2;ATP1B1;MUC5B;KCNN4;GUCY1A3;VAMP2;LYZ;CAMP

GUCY1A3 has several biochemical functions, for example, GTP binding, NOT adenylate cyclase activity, guanylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCY1A3 itself. We selected most functions GUCY1A3 had, and list some proteins which have the same functions with GUCY1A3. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	SEPT1;RASL11B;IRGE4;DNAJC27;RALBB;SEPT2;RAP2C;RAB18A;MFN1B
NOT adenylate cyclase activity	GC3;NPR1A;GUCY1A3;NPR3;NPR2;GUCY1B3;GC2;GUCY2C;GUCY2F
guanylate cyclase activity	NPR1;GC2;GC3;GUCY1B3;NPR1A;GUCY2F;NPR2;GUCY2C;GUCY2E
heme binding	CYP4F3;CYP2D26;MPO;CYP4Z1;DGCR8;CYP26A1;CYP2U1;HBB-BH1;DUOX2
protein binding	NRP1B;NPBWR1;NIPA2;ZNF514;NMRK2;TRIM17;BAZ1B;a;RAB1
protein heterodimerization activity	TPD52;BCL11A;TPD52L2;MPP7;HIF1A;ARNT;MAPK6;PPP3CA;HAND1
receptor activity	NLGN3A;Siglece;BTN1A1;NLGN4A;LYVE1;CD200R2;PAQR9;NPC1;NPY2R

GUCY1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCY1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCY1A3.

GUCY1B3; gtp; MAPK8; IKBKG

Fusco, DN; Brisac, C; et al. A Genetic Screen Identifies Interferon-alpha Effector Genes Required to Suppress Hepatitis C Virus Replication. GASTROENTEROLOGY 144:1438-U210(2013).

Priora, R; Margaritis, A; et al. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. PHARMACOLOGICAL RESEARCH 64:289-297(2011).