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GUSB

  • Official Full Name

    glucuronidase, beta

  • Overview

    This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
  • Synonyms

    GUSB; glucuronidase, beta; beta-glucuronidase; Ac2-223; asd; Beta G1; Beta glucuronidase; Beta-G1; BG; BGLR; BGLR_HUMAN; FLJ39445; Glucuronidase beta; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; MPS 7; MPS7; OTTHUMP00000159848; OTTHUMP00000210106; beta-D-glucuronidase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Helix pomatia
  • Human
  • Mouse
  • Rat
  • Baculovirus cells
  • E.coli
  • HEK293
  • HEK293T
  • Helix Pomatia
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GUSB-179H Active Recombinant Human GUSB, His-tagged Mammalian cells His
Human GUSB-4500H Recombinant Human GUSB Protein, GST-tagged Wheat Germ GST
Human GUSB-27205TH Recombinant Human GUSB Wheat Germ N/A 630 amino acids
Human GUSB-6928H Recombinant Human GUSB protein, His & T7-tagged E.coli His/T7 Glu451~Leu649 (Accession # P08236)
Human GUSB-5673HCL Recombinant Human GUSB 293 Cell Lysate HEK293 N/A
Human GUSB-5742H Recombinant Human GUSB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GUSB-001H Active Recombinant Human GUSB Protein Baculovirus cells His
Human GUSB-2348H Recombinant Human GUSB Protein (Glu451-Leu649), N-His tagged E.coli N-His Glu451-Leu649
Human GUSB-3357HF Recombinant Full Length Human GUSB Protein, GST-tagged In Vitro Cell Free System GST 651 amino acids
Human GUSB-211HF Recombinant Full Length Human GUSB Protein In Vitro Cell Free System 630 amino acids
Human GUSB-2155HFL Recombinant Full Length Human GUSB Protein, C-Flag-tagged Mammalian cells Flag
Human GUSB-1034H Recombinant Human GUSB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GUSB-1034H-B Recombinant Human GUSB Protein Pre-coupled Magnetic Beads HEK293
Mouse Gusb-6929M Recombinant Mouse Gusb protein, His & T7-tagged E.coli His/T7 Ala451~Phe648 (Accession # P12265)
Mouse GUSB-7397M Recombinant Mouse GUSB Protein Mammalian Cell His
Mouse Gusb-446M Recombinant Mouse Gusb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse GUSB-4015M-B Recombinant Mouse GUSB Protein Pre-coupled Magnetic Beads HEK293
Mouse GUSB-4015M Recombinant Mouse GUSB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gusb-6930R Recombinant Rat Gusb protein, His-tagged E.coli His Val440~Phe648
Rat GUSB-2763R Recombinant Rat GUSB Protein Mammalian Cell His
Rat GUSB-2417R Recombinant Rat GUSB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GUSB-2417R-B Recombinant Rat GUSB Protein Pre-coupled Magnetic Beads HEK293
Helix pomatia GUSB-12H Active Native Helix pomatia b-Glucuronidase Helix Pomatia N/A
Chicken GUSB-3374C Recombinant Chicken GUSB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GUSB Related Articles
  • GUSB Related Research Area

GUSB involved in several pathways and played different roles in them. We selected most pathways GUSB participated on our site, such as Pentose and glucuronate interconversions, Starch and sucrose metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsUGT5G1;AKR1A1B;UGT1A3;CRYL1;UGT1A6B;UGT1A4;XYLB;UGT1A1;AKR1B7
Starch and sucrose metabolismGPI1;UGT1A2;UGT1A7C;AMY1A;UGP2A;SI;AMY2A3;GBE1;UGT5G1
Glycosaminoglycan degradationIDUA;SPAM1;IDS;GALNS;GUSB;HGSNAT;HYAL3;GNSA;HYAL6
Porphyrin and chlorophyll metabolismHCCSB;UGT1A1;UGT2B7;PPOX;ALAS1;UGT5G1;HMOX2;UGT1A9;COX10
Drug metabolism - other enzymesNAT;UGT2B7;UGT5G1;GMPS;UGT2B15;IMPDH1A;UGT1A3;NAT1;UCK2B
Metabolic pathwaysAK7;ACADSB;CYP4A12A;CYP2A4;LDHAL6B;IMPA2;UQCR11;PKM;LIPF
LysosomeGM2A;AP1S3;HGSNAT;HEXA;SUMF1;SORT1B;GNSB;MFSD8;TCEAL4

GUSB has several biochemical functions, for example, beta-glucuronidase activity, protein domain specific binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GUSB itself. We selected most functions GUSB had, and list some proteins which have the same functions with GUSB. You can find most of the proteins on our site.

Function Related Protein
beta-glucuronidase activityGUSB;HPSE
protein domain specific bindingE2F4;PPARA;MRPL17;STRN4;CALM1;STMN3;NFASC;TACC1;NF2
receptor bindingANGPT2;UCN2;MTSS1;TRDN;KCNJ10;NPPB;FKBP1B;BAAT;GBA

GUSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUSB here. Most of them are supplied by our site. Hope this information will be useful for your research of GUSB.

GIT2; A2M; cona_canen

Boado, RJ; Pardridge, WM; et al. Genetic engineering of IgG-glucuronidase fusion proteins. JOURNAL OF DRUG TARGETING 18:205-211(2010).
Zhang, Y; Wang, Y; et al. Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer. PHARMACEUTICAL RESEARCH 25:400-406(2008).
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