Gad2
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Official Full Name
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
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Overview
Adults express two forms of glutamate decarboxylase (GAD), GAD65 and GAD67, which are encoded by different independently regulated genes. Both are expressed in most GABA containing neurons. GAD65 appears to be targeted to the membrane and nerve endings; while GAD67 is more widely distributed throughout the cell. GAD65 preferentially synthesizes GABA for vesicular release and GAD67 preferentially synthesizes cytoplasmic GABA. GAD65 is predominantly expressed in pancreatic beta cells and autoantibodies to GAD65 are strongly associated with Insulin-dependent diabetes mellitus (IMDM). -
Synonyms
GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform; MGC161605; MGC161607;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
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- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|S
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Gad2 Related Articles
- Gad2 Related Research Area
Gad2 involved in several pathways and played different roles in them. We selected most pathways Gad2 participated on our site, such as Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gad2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alanine, aspartate and glutamate metabolism | AGXT;GOT2A;AGXT2;ASS1;GPT;ASL;GOT1;GLUD1;GLULC |
beta-Alanine metabolism | AOC3;ALDH6A1;HIBCH;AOC2;SRM;ALDH9A1;ALDH9A1A.1;ALDH3A2A;ALDH3A2 |
Taurine and hypotaurine metabolism | GGT1;CDO1;GAD2;ADOB;GGT1A;BAAT;CSAD;GGT5;GAD1 |
Butanoate metabolism | HADHA;OXCT2;OXCT1;Acsm2a;BDH1;HMGCLL1;OXCT2B;ACSM1;GAD1 |
Metabolic pathways | PET112L;GPI1;GALNT14;MTHFD1B;UGT1A7;GBGT1;FPGS;ALPP;HSD17B1 |
GABAergic synapse | SLC12A5;GABRA6;GABARAP;GNG10;GNGT1;PRKCB;GNG12;PRKACA;GNAI3 |
Type I diabetes mellitus | ICA1;IL12A;H2-Q10;IFNG;Fasl;CPE;HLA-F;HLA-G;H2-AA |
Gad2 has several biochemical functions, for example, glutamate binding, glutamate decarboxylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gad2 itself. We selected most functions Gad2 had, and list some proteins which have the same functions with Gad2. You can find most of the proteins on our site.
Function | Related Protein |
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glutamate binding | GRIN1;GLUL;CPS1;SLC1A3;GRM7;GAD2;GRIN2A;GRIK1;SLC1A1 |
glutamate decarboxylase activity | GAD1;GAD1B;GAD2;GLUL |
protein binding | SP2;PDZK1;RNF139;LPXN;RPGR;TAF7;ZNF410;USP1;L3MBTL4 |
protein heterodimerization activity | HIST1H2B5;EPAS1;MYH7;PDGFB;H2AFY2;CEBPG;PDZD7;ALG2;FZD9 |
pyridoxal phosphate binding | GPT2;NFS1;PHYKPL;GPT2L;SPTLC2;SHMT1;SRR;ALAS2;KYNU |
Gad2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gad2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gad2.
ARL6IP1; AGTRAP; MAL2; TMEM159; CMTM5
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, genetic variations in the GAD2 gene have been associated with an increased risk of developing certain neurological disorders, indicating a genetic component in their etiology.
Pharmacological agents targeting GAD2 activity are being explored to modulate GABAergic neurotransmission, potentially offering novel treatments for neurological disorders.
Yes, elevated or reduced levels of GAD2 protein can serve as a diagnostic marker for certain neurological disorders, aiding in their identification and management.
GAD2 protein is linked to neurological disorders like epilepsy, Parkinson's disease, and various psychiatric conditions due to its role in regulating GABA levels, which are crucial for proper neuronal function.
Research is ongoing to develop therapeutic interventions that modulate GAD2 activity, aiming to restore GABAergic balance in the brain and potentially treat related neurological disorders.
Customer Reviews (3)
Write a reviewThe GAD2 protein exhibits remarkable performance in Western blotting (WB) experiments.
The versatility and efficacy of GAD2 in these applications make it an invaluable tool for researchers.
Researchers can rely on GAD2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.
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