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Gar1

Official Full Name

GAR1 GAR1 ribonucleoprotein homolog (yeast) [ Homo sapiens ]
Overview

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Synonyms

GAR1 ribonucleoprotein homolog (yeast); 14264; Ensembl:ENSG00000109534; H/ACA ribonucleoprotein complex subunit 1; snoRNP protein GAR1; nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); NOLA1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GAR1-13156H	Recombinant Human GAR1, GST-tagged	E.coli	GST	1-217a.a.	$319 / 25ug
Human	GAR1-6021HCL	Recombinant Human GAR1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GAR1-5978H	Recombinant Human GAR1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	GAR1-6209M	Recombinant Mouse GAR1 Protein	Mammalian Cell	His		Inquiry
Mouse	GAR1-3468M	Recombinant Mouse GAR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GAR1-3468M-B	Recombinant Mouse GAR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Gar1-4456M	Recombinant Mouse Gar1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	GAR1-2478R	Recombinant Rat GAR1 Protein	Mammalian Cell	His		Inquiry
Rat	GAR1-2134R	Recombinant Rat GAR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GAR1-2134R-B	Recombinant Rat GAR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GAR1-11210Z	Recombinant Zebrafish GAR1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Gar1 Related Articles

Gar1 involved in several pathways and played different roles in them. We selected most pathways Gar1 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gar1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome biogenesis in eukaryotes	NOP10;NXF2;BARHL1;SPATA5;NOP56;MPHOSPH10;NXT1;POP4;RBM28

Gar1 has several biochemical functions, for example, cation channel activity, poly(A) RNA binding, telomerase RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gar1 itself. We selected most functions Gar1 had, and list some proteins which have the same functions with Gar1. You can find most of the proteins on our site.

Function	Related Protein
cation channel activity	FAM26D;FAM26E;FAM26F;PKD2L1;GRIN2A;ASIC1A;ASIC4B;FAM38B;TRPM1B
poly(A) RNA binding	GANAB;HMGB2;SF3B4;SNTB2;RPL30;RPF2;SERPINH1;DDX28;DDX5
telomerase RNA binding	TERT;HNRNPU;DKC1;NHP2;HNRNPC;GAR1;PINX1;WRAP53;NOP10

Gar1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gar1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gar1.

SMN1; DKC1; USP10; USP39; Nhp2l1; ssdna_dtdg; TAF1; FAAP20; CEP89; PRMT5; GABARAP; FN1; ALB; MAPT; MNDA; CLNS1A; RPL27; HSPG2

Chauvin, C; Koka, V; et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. ONCOGENE 33:474-483(2014).

von Stedingk, K; Koster, J; et al. snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis. TRANSLATIONAL ONCOLOGY 6:447-U142(2013).