Gas6
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Official Full Name
growth arrest-specific 6
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Overview
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
GAS6; growth arrest-specific 6; AXSF; AXLLG; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Gas6 Related Articles
- Gas6 Related Research Area
Gas6 involved in several pathways and played different roles in them. We selected most pathways Gas6 participated on our site, such as Cell surface interactions at the vascular wall, Gamma carboxylation, hypusine formation and arylsulfatase activation, Gamma-carboxylation of protein precursors, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gas6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell surface interactions at the vascular wall | GRB14;CXADR;JAM2B;GRB7;SLC7A8A;GLG1B;ESAMA;SLC7A6;MERTK |
Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSF;EIF5A2;ARSD;DHPS;DPH2;F9B;ARSE;DOHH;DPH5 |
Gamma-carboxylation of protein precursors | F9A;PROZ;PROCA;GAS6;F9B |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | FURINA;GAS6;PROZ;F9A;PROCA;F9B;FURINB |
Hemostasis | AKAP1B;LOC100514666;PIK3R6;HBBE2;DOCK9;BA1;ANXA2A;PHF21A;IGF2B |
Metabolism of proteins | TOMM70A;APCS;SPON1B;MPDU1B;B3GNT3;KCNA6;TBCB;TGFBI;GALNT6 |
Platelet activation, signaling and aggregation | C6orf25;F13A1A.1;AASS;CALU;MMRN1;F13A1B;G6b;STXBP3A;TFA |
Platelet degranulation | F13A1A.1;BRPF3;SPARC;F13A1B;CLU;SRGN;CALU;SCG3;CD9A |
Gas6 has several biochemical functions, for example, binding, bridging, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Gas6 itself. We selected most functions Gas6 had, and list some proteins which have the same functions with Gas6. You can find most of the proteins on our site.
Function | Related Protein |
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binding, bridging | GAS6;PDCD6;TRADD |
calcium ion binding | FKBP14;MFGE8B;RPH3AL;SRI;C1rb;SLC25A25A;RCVRNA;MAN1A2;S100A8 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process | DPEP1;XIAP;VIL1;TFAP2B;GAS6;IGF1RA;ARRB1;RPS6KA1;TNFAIP8 |
phosphatidylserine binding | AXL;OSBPL5;AP1S2;CPNE1;PLCD1;SCARB1;TRIM72;CPNE6;ANXA9 |
protein binding | TMED1;PHF17;DPPA4;AGTRAP;GUCY1B3;POLDIP2;RLN3;COX4I1;NUDT18 |
protein tyrosine kinase activator activity | AFAP1L2;GAS6;ABI1;ABI3A;ERBB3;Cd24a;NRG1;GHRL;CD24 |
receptor agonist activity | WNT3;SFRP2;NODAL;WNT4;WNT5A;WNT3A;WNT2;WNT10B;GAS6 |
receptor binding | ICAM3;FGF1A;RSPO1;APOF;F2RL1;TNFSF10;CADM1B;DIAPH1;LRP6 |
receptor tyrosine kinase binding | PLCG1;FNTA;LRP4;DNAJA3;PTPN1;ELMO2;HYAL2;GNB2L1;FLT3LG |
voltage-gated calcium channel activity | RYR1;TPC3;CACNG2A;GAS6;CACNG7;CACNA1SA;NALCN;CACNB4B;CACNA2D2 |
Gas6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gas6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gas6.
AXL; ppdK; hemC
- Q&As
- Reviews
Q&As (6)
Ask a questionExpression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.
The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.
GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.
Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore
It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.
Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.
Customer Reviews (3)
Write a reviewGAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.
The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.
Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.
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