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GJA1

  • Official Full Name

    gap junction protein, alpha 1, 43kDa

  • Overview

    This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq, Jul 2008]
  • Synonyms

    GJA1; gap junction protein, alpha 1, 43kDa; HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; DFNB38; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Cynomolgus Monkey
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Erinaceus europaeus (Western European hedgehog)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Ursus americanus (American black bear) (Euarctos americanus)
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Insect Cell
  • Mammalian Cell
  • Yeast
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GJA1-350H Recombinant Human GJA1 protein, His-tagged E.coli His Ser244~Ile382
Human GJA1-5923HCL Recombinant Human GJA1 293 Cell Lysate HEK293 N/A
Human GJA1-2221H Recombinant Human GJA1 protein, His-tagged Insect Cell His 233-382aa
Human GJA1-2962H Recombinant Human GJA1 protein, His-tagged E.coli His 233-382aa
Human GJA1-1312H Recombinant Human GJA1 protein, His-tagged HEK293 His 233-382aa
Human GJA1-2204H Recombinant Human GJA1 Protein, His-tagged E.coli N-His Ser180-Ile382
Human GJA1-2081H Recombinant Human GJA1 Protein (Phe232-Ile382), N-His tagged E.coli N-His Phe232-Ile382
Mouse GJA1-6368M Recombinant Mouse GJA1 Protein Mammalian Cell His
Mouse Gja1-351M Recombinant Mouse Gja1 Protein, His-tagged E.coli His Ser180~Ile382
Mouse GJA1-893M Recombinant Mouse GJA1 protein, His-tagged E.coli His Ser180-Ile382
Mouse Gja1-5414M Recombinant Mouse Gja1 protein, His-Myc-tagged Yeast His/Myc 232-382aa
Mouse Gja1-951M Recombinant Mouse Gja1 Protein, His-tagged HEK293F N-His Ser244-Ile382
Mouse Gja1-1310M Recombinant Mouse Gja1 protein, His&Myc-tagged HEK293 His&Myc 232-382aa
Mouse Gja1-2222M Recombinant Mouse Gja1 protein, His&Myc-tagged Insect Cell His&Myc 232-382aa
Mouse GJA1-3569M Recombinant Mouse GJA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GJA1-3569M-B Recombinant Mouse GJA1 Protein Pre-coupled Magnetic Beads HEK293
Rat GJA1-2545R Recombinant Rat GJA1 Protein Mammalian Cell His
Rat Gja1-352R Recombinant Rat Gja1 Protein, His-tagged E.coli His Ser180~Ile382
Rat GJA1-2201R-B Recombinant Rat GJA1 Protein Pre-coupled Magnetic Beads HEK293
Rat GJA1-2201R Recombinant Rat GJA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL25501BF Recombinant Full Length Bovine Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-383)
Canis lupus familiaris (Dog) (Canis familiaris) RFL16814CF Recombinant Full Length Dog Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL11577CF Recombinant Full Length Chlorocebus Aethiops Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Cynomolgus Monkey GJA1-545C Recombinant Cynomolgus GJA1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GJA1-290C-B Recombinant Cynomolgus Monkey GJA1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GJA1-290C Recombinant Cynomolgus Monkey GJA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Danio rerio (Zebrafish) (Brachydanio rerio) RFL8003DF Recombinant Full Length Danio Rerio Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-381)
Erinaceus europaeus (Western European hedgehog) RFL35560EF Recombinant Full Length Erinaceus Europaeus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Gallus gallus (Chicken) RFL15966GF Recombinant Full Length Chicken Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-381)
Homo sapiens (Human) RFL10056HF Recombinant Full Length Human Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (1-382)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL33951MF Recombinant Full Length Macaca Fascicularis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Mus musculus (Mouse) RFL23029MF Recombinant Full Length Mouse Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (1-382)
Oryctolagus cuniculus (Rabbit) RFL32091OF Recombinant Full Length Rabbit Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (1-382)
Rattus norvegicus (Rat) RFL11994RF Recombinant Full Length Rat Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Rhesus Macaque GJA1-1857R Recombinant Rhesus monkey GJA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GJA1-1677R Recombinant Rhesus Macaque GJA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GJA1-1677R-B Recombinant Rhesus Macaque GJA1 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL28095SF Recombinant Full Length Pig Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Ursus americanus (American black bear) (Euarctos americanus) RFL34047UF Recombinant Full Length Ursus Americanus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-382)
Xenopus laevis (African clawed frog) RFL2841XF Recombinant Full Length Xenopus Laevis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-379)
Chicken GJA1-6155C Recombinant Chicken GJA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GJA1 Related Articles
  • GJA1 Related Research Area

GJA1 involved in several pathways and played different roles in them. We selected most pathways GJA1 participated on our site, such as Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gap junctionRAF1;PRKCG;ADRB3A;TUBA8;TUBA1L2;HTR2B;TUBA8L2;PRKACAB;GNAIA
Arrhythmogenic right ventricular cardiomyopathy (ARVC)LAMA2;ACTB;RYR2;ACTN3;EMD;ITGA9;ACTG1;CACNA2D1;CACNG1

GJA1 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, connexin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA1 itself. We selected most functions GJA1 had, and list some proteins which have the same functions with GJA1. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingARHGEF16;ATP2B3B;GRIK2;FZD7;GIPC1;CIT;LLGL2;BAIAP2;SLC22A12
SH3 domain bindingCBL;ARHGAP6;FAM125A;PDCD6IP;DTX1;CRB3;ZFP106;NCKIPSD;LRP2
connexin bindingCAV3;CNSTB;CXADR;GJA5;CNST;GJA1
gap junction channel activityGJA1;CX30.3;GJA10;CX23;GJC2;GJA8;GJB2;CX43;CX52.6
gap junction channel activity involved in cardiac conduction electrical couplingGJA1;GJA5
gap junction channel activity involved in cell communication by electrical coupling
ion transmembrane transporter activitySFXN2;S100A6;TRPV2;LASP1;SFXN3;GJA1;SFXN5B;PLP2;SFXN1
protein bindingARHGEF16;NAA50;RBM12B;VTN;ROCK2;EIF5A2;DUSP26;OAS3;CD93
signal transducer activityVMN1R40;S1PR5A;TAS2R129;FPR-RS6;OLFR502;MC5RA;TAAR12E;PLCD4;OLFR181

GJA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA1.

TJP1; CSK; DSC2; TFCP2; SRC

Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).
Choudhury, A; Khole, VV; et al. HSP90 Antibodies: A Detrimental Factor Responsible for Ovarian Dysfunction. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 70:372-385(2013).
  • Q&As
  • Reviews

Q&As (5)

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Can GJA1 be a potential therapeutic target for cancer treatment? 05/25/2021

Research suggests that targeting GJA1 may have therapeutic potential in cancer treatment, although further studies are needed to validate this approach.

Are there any neurologic implications of GJA1 mutations? 09/04/2019

Yes, GJA1 mutations have been associated with neurological disorders, including Charcot-Marie-Tooth disease, a group of peripheral neuropathies affecting motor and sensory nerves.

How is GJA1 involved in bone development and maintenance? 04/01/2019

GJA1 is expressed in bone cells and plays a role in the communication between osteoblasts and osteocytes. Mutations may lead to skeletal abnormalities.

Are there any diagnostic tools specifically targeting GJA1 for clinical use? 02/09/2019

Currently, there are no widely used diagnostic tools specifically targeting GJA1. However, research is ongoing to explore its potential as a diagnostic marker.

Are there ongoing clinical trials targeting GJA1 for therapeutic interventions? 10/23/2017

Yes, there are some clinical trials exploring the modulation of GJA1 expression or function for potential therapeutic benefits in certain diseases.

Customer Reviews (3)

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Reviews
02/12/2021

    They actively listen to my experimental needs and tailor their services accordingly, recognizing the unique requirements of my research.

    08/22/2018

      With their assistance, I can confidently delve into the intricacies of GJA1 and make significant contributions to the field of ARID3C-related research.

      10/02/2016

        This collaborative partnership contributes to a productive and efficient research experience, as I can rely on their expertise and assistance throughout the process.

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