GJA1
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Official Full Name
gap junction protein, alpha 1, 43kDa
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Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq, Jul 2008] -
Synonyms
GJA1; gap junction protein, alpha 1, 43kDa; HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; DFNB38; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Cynomolgus Monkey
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Erinaceus europaeus (Western European hedgehog)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Ursus americanus (American black bear) (Euarctos americanus)
- Xenopus laevis (African clawed frog)
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- Insect Cell
- Mammalian Cell
- Yeast
- His
- His (Fc)
- Avi
- Myc
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | GJA1-350H | Recombinant Human GJA1 protein, His-tagged | E.coli | His | Ser244~Ile382 | |
Human | GJA1-5923HCL | Recombinant Human GJA1 293 Cell Lysate | HEK293 | N/A | ||
Human | GJA1-2221H | Recombinant Human GJA1 protein, His-tagged | Insect Cell | His | 233-382aa | |
Human | GJA1-2962H | Recombinant Human GJA1 protein, His-tagged | E.coli | His | 233-382aa | |
Human | GJA1-1312H | Recombinant Human GJA1 protein, His-tagged | HEK293 | His | 233-382aa | |
Human | GJA1-2204H | Recombinant Human GJA1 Protein, His-tagged | E.coli | N-His | Ser180-Ile382 | |
Human | GJA1-2081H | Recombinant Human GJA1 Protein (Phe232-Ile382), N-His tagged | E.coli | N-His | Phe232-Ile382 | |
Mouse | GJA1-6368M | Recombinant Mouse GJA1 Protein | Mammalian Cell | His | ||
Mouse | Gja1-351M | Recombinant Mouse Gja1 Protein, His-tagged | E.coli | His | Ser180~Ile382 | |
Mouse | GJA1-893M | Recombinant Mouse GJA1 protein, His-tagged | E.coli | His | Ser180-Ile382 | |
Mouse | Gja1-5414M | Recombinant Mouse Gja1 protein, His-Myc-tagged | Yeast | His/Myc | 232-382aa | |
Mouse | Gja1-951M | Recombinant Mouse Gja1 Protein, His-tagged | HEK293F | N-His | Ser244-Ile382 | |
Mouse | Gja1-1310M | Recombinant Mouse Gja1 protein, His&Myc-tagged | HEK293 | His&Myc | 232-382aa | |
Mouse | Gja1-2222M | Recombinant Mouse Gja1 protein, His&Myc-tagged | Insect Cell | His&Myc | 232-382aa | |
Mouse | GJA1-3569M | Recombinant Mouse GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | GJA1-3569M-B | Recombinant Mouse GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | GJA1-2545R | Recombinant Rat GJA1 Protein | Mammalian Cell | His | ||
Rat | Gja1-352R | Recombinant Rat Gja1 Protein, His-tagged | E.coli | His | Ser180~Ile382 | |
Rat | GJA1-2201R-B | Recombinant Rat GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | GJA1-2201R | Recombinant Rat GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bos taurus (Bovine) | RFL25501BF | Recombinant Full Length Bovine Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-383) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL16814CF | Recombinant Full Length Dog Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | RFL11577CF | Recombinant Full Length Chlorocebus Aethiops Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Cynomolgus Monkey | GJA1-545C | Recombinant Cynomolgus GJA1 Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | GJA1-290C-B | Recombinant Cynomolgus Monkey GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cynomolgus Monkey | GJA1-290C | Recombinant Cynomolgus Monkey GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Danio rerio (Zebrafish) (Brachydanio rerio) | RFL8003DF | Recombinant Full Length Danio Rerio Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-381) | |
Erinaceus europaeus (Western European hedgehog) | RFL35560EF | Recombinant Full Length Erinaceus Europaeus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Gallus gallus (Chicken) | RFL15966GF | Recombinant Full Length Chicken Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-381) | |
Homo sapiens (Human) | RFL10056HF | Recombinant Full Length Human Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (1-382) | |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | RFL33951MF | Recombinant Full Length Macaca Fascicularis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Mus musculus (Mouse) | RFL23029MF | Recombinant Full Length Mouse Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (1-382) | |
Oryctolagus cuniculus (Rabbit) | RFL32091OF | Recombinant Full Length Rabbit Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (1-382) | |
Rattus norvegicus (Rat) | RFL11994RF | Recombinant Full Length Rat Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Rhesus Macaque | GJA1-1857R | Recombinant Rhesus monkey GJA1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | GJA1-1677R | Recombinant Rhesus Macaque GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | GJA1-1677R-B | Recombinant Rhesus Macaque GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Sus scrofa (Pig) | RFL28095SF | Recombinant Full Length Pig Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Ursus americanus (American black bear) (Euarctos americanus) | RFL34047UF | Recombinant Full Length Ursus Americanus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-382) | |
Xenopus laevis (African clawed frog) | RFL2841XF | Recombinant Full Length Xenopus Laevis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-379) | |
Chicken | GJA1-6155C | Recombinant Chicken GJA1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- GJA1 Related Articles
- GJA1 Related Research Area
GJA1 involved in several pathways and played different roles in them. We selected most pathways GJA1 participated on our site, such as Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Gap junction | RAF1;PRKCG;ADRB3A;TUBA8;TUBA1L2;HTR2B;TUBA8L2;PRKACAB;GNAIA |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | LAMA2;ACTB;RYR2;ACTN3;EMD;ITGA9;ACTG1;CACNA2D1;CACNG1 |
GJA1 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, connexin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA1 itself. We selected most functions GJA1 had, and list some proteins which have the same functions with GJA1. You can find most of the proteins on our site.
Function | Related Protein |
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PDZ domain binding | ARHGEF16;ATP2B3B;GRIK2;FZD7;GIPC1;CIT;LLGL2;BAIAP2;SLC22A12 |
SH3 domain binding | CBL;ARHGAP6;FAM125A;PDCD6IP;DTX1;CRB3;ZFP106;NCKIPSD;LRP2 |
connexin binding | CAV3;CNSTB;CXADR;GJA5;CNST;GJA1 |
gap junction channel activity | GJA1;CX30.3;GJA10;CX23;GJC2;GJA8;GJB2;CX43;CX52.6 |
gap junction channel activity involved in cardiac conduction electrical coupling | GJA1;GJA5 |
gap junction channel activity involved in cell communication by electrical coupling | |
ion transmembrane transporter activity | SFXN2;S100A6;TRPV2;LASP1;SFXN3;GJA1;SFXN5B;PLP2;SFXN1 |
protein binding | ARHGEF16;NAA50;RBM12B;VTN;ROCK2;EIF5A2;DUSP26;OAS3;CD93 |
signal transducer activity | VMN1R40;S1PR5A;TAS2R129;FPR-RS6;OLFR502;MC5RA;TAAR12E;PLCD4;OLFR181 |
GJA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA1.
TJP1; CSK; DSC2; TFCP2; SRC
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch suggests that targeting GJA1 may have therapeutic potential in cancer treatment, although further studies are needed to validate this approach.
Yes, GJA1 mutations have been associated with neurological disorders, including Charcot-Marie-Tooth disease, a group of peripheral neuropathies affecting motor and sensory nerves.
GJA1 is expressed in bone cells and plays a role in the communication between osteoblasts and osteocytes. Mutations may lead to skeletal abnormalities.
Currently, there are no widely used diagnostic tools specifically targeting GJA1. However, research is ongoing to explore its potential as a diagnostic marker.
Yes, there are some clinical trials exploring the modulation of GJA1 expression or function for potential therapeutic benefits in certain diseases.
Customer Reviews (3)
Write a reviewThey actively listen to my experimental needs and tailor their services accordingly, recognizing the unique requirements of my research.
With their assistance, I can confidently delve into the intricacies of GJA1 and make significant contributions to the field of ARID3C-related research.
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