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GNAI1

  • Official Full Name

    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

  • Overview

    Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.
  • Synonyms

    GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1; Gi1 protein alpha subunit; adenylate cyclase-inhibiting G alpha protein; Gi;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Baculovirus-Insect cells
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mouse
  • Wheat Germ
  • GST
  • His
  • HIS
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • TwinStrep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNAI1-189H Active Recombinant Human GNAI1 protein, GST-tagged E.coli GST 2-end
Human GNAI1-13346H Recombinant Human GNAI1, GST-tagged E.coli GST 1-354a.a.
Human GNAI1-28963TH Recombinant Human GNAI1 Protein, His-tagged E. coli HIS
Human GNAI1-6873H Recombinant Human Guanine Nucleotide Binding Protein (G protein), Alpha Inhibiting Activity Polypeptide 1, His-tagged E.coli His 1-354aa
Human GNAI1-5041H Recombinant Human GNAI1 Protein, GST-tagged Wheat Germ GST
Human GNAI1-5322HF Recombinant Full Length Human GNAI1 Protein, GST-tagged In Vitro Cell Free System GST 354 amino acids
Human GNAI1-1952H Recombinant Human GNAI1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse GNAI1-7014M Recombinant Mouse GNAI1 Protein Mammalian Cell His
Mouse Gnai1-3254M Recombinant Mouse Gnai1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GNAI1-3756M-B Recombinant Mouse GNAI1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GNAI1-3756M Recombinant Mouse GNAI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GNAI1-2593R Recombinant Rat GNAI1 Protein Mammalian Cell His
Rat GNAI1-2248R-B Recombinant Rat GNAI1 Protein Pre-coupled Magnetic Beads HEK293
Rat DMABT-H16571 Mouse Anti-Gnai1 Monoclonal Antibody Mouse N/A
Rat GNAI1-2248R Recombinant Rat GNAI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine GNAI1-0033B Recombinant Bovine GNAI1 Protein (Gly2-Phe354), N-TwinStrep-tagged Baculovirus-Insect cells N-TwinStrep Gly2-Phe354
Zebrafish GNAI1-11206Z Recombinant Zebrafish GNAI1 Mammalian Cell His
Chicken GNAI1-6954C Recombinant Chicken GNAI1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GNAI1 involved in several pathways and played different roles in them. We selected most pathways GNAI1 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayGRIN1;PDGFRA;RHOA;ID1;IGF1;MLLT4;MAPK3;LPAR2;HGF
cGMP-PKG signaling pathwaySLC25A6;BAD;PRKG2;GNA11;ITPR3;PDE3A;PPP3R1;PDE5A;NFATC3
cAMP signaling pathwayHCN4;ATP1B1;ATP2B4;GRIA2;GRIN3B;MAP2K1;DRD1A;PDE4B;HCAR2
Chemokine signaling pathwayCCL21;PIK3R5;Ccl9;CXCR5;HCK;CRK;PRKCB;JAK3;CCL22
Sphingolipid signaling pathwayFYN;BAX;ROCK2;MAPK12;TRAF2;PIK3CB;ACER1;MAPK13;PDPK1
Adrenergic signaling in cardiomyocytesCAMK2D;PPP2R5EB;CREB1A;TNNT2;ATP2A2;PIK3R2;BCL2A;ATF6B;CACNA1DA
Axon guidanceDUSP4;GSK3B;SEMA5B;PLXNA1;NTNG1;DNM1;EPHA7;ABLIM1;EPHB3
Tight junctionSHROOM1;PPP2R2D;CLDNH;MYLPF;CLDN18;TJP2;PRKCI;MYH11A;CLDN11
Gap junctionAdcy4;DRD1A;GNA15.1;PRKACAA;GNAI2;PDGFA;GNA11;MAPK7;MAP2K2A
Platelet activationGP1BA;RAP1B;AKT1;GP5;GNAI1;RHOA;PRKACA;ITGA2;PIK3CA
Leukocyte transendothelial migrationVAV2;MYL2;PIK3R3;RAC1;CLDN22;CD99;Itgam&Itgb2;GNAI2;PLCG1
Circadian entrainmentCAMK2G;MAPK3;GRIN2C;PER2;GNB4;PRKCG;NOS1AP;CAMK2D;PER1
Retrograde endocannabinoid signalingGRIA3;GNG3;GNG7;GNAI2;SLC17A8;GABRG2;GRM1;PRKACG;SLC17A6
Glutamatergic synapseGNGT2;GNAQ;SLC38A1;SHANK1;GNG5;GRIN3B;GNAS;PRKACA;GRIN2A
Cholinergic synapsePIK3R2;CHRM3;PRKCB;KCNJ12;GNG8;CREB3;KCNJ6;CAMK2D;ITPR3
Serotonergic synapsePRKCA;CYP2C38;GNAQ;CYP2C37;APP;GNGT2;PTGS1;PLA2G4F;HTR7
GABAergic synapseGNB3;GNG11;GABRB2;GLUL;GNG3;PRKACA;GNB4;SRC;SLC38A3
Dopaminergic synapseGNAI1;GNG12;CREB3L1;GNB3;DRD1A;PPP1CA;PPP2R2D;AKT1;GRIN2A
Long-term depressionPLA2G4A;GRID2;RYR1;ITPR3;GNAQ;PLA2G4C;PLCB3;PRKCB;GNAS
Progesterone-mediated oocyte maturationRPS6KA1;CDK1;PRKACBA;ADCY1A;MAPK9;CPEB1B;ANAPC4;ANAPC5;CCNA2
Estrogen signaling pathwayPLCB1;CREB3L1;PRKACB;HSPA1L;SHC1;PIK3CB;HSP90B1;Adcy4;HSPA6
MelanogenesisCALM3A;PRKCA;WNT5B;WNT4;PRKCBA;CAMK2B1;GNAS;POMCA;NRAS
Oxytocin signaling pathwayGNAO1;NFATC1;PIK3CG;PRKACG;MYLK4;PIK3R5;PIK3R1;GUCY1B3;OXT
Regulation of lipolysis in adipocytesAKT2;GNAI1;GNAS;PIK3R5;GNAI2;PTGS2;AKT1;PTGER3;INS1
Renin secretionPRKACB;PLCB4;AQP1;CALM4;REN;PPP3CB;GNAI2;PLCB1;GUCY1B3
Gastric acid secretionSLC9A4;SST;ATP4A;KCNK2;KCNJ15;SLC9A1;HRH2;ACTB;ATP1B4
Parkinsons diseaseLRRK2;NDUFA1;SDHA;NDUFAB1;SLC18A2;SDHB;NDUFS8;UQCRH;GNAI2
Cocaine addictionCREB3L2;CREB3L1;GRIN1;CDK5;MAOA;GRIA2;MAOB;DRD1;DRD2
AlcoholismCAMKK1;GM14478;KRAS;GNG4;HIST1H2BP;CREB3L1;GNB2;HDAC4;MAPK1
PertussisIl23a;IL-8;CD14;IRF1;C3;IL12B;C1QA;IL1A;MAPK11
Chagas disease (American trypanosomiasis)NFKB1;C1QB;GNA14;Il2;CCL3;CCL5;PIK3CG;AKT1;PLCB1
ToxoplasmosisTNF;CASP8;BIRC8;TYK2;BCL2L1;HSPA6;IFNGR2;ALOX5;NFKBIB
Pathways in cancerIGF1R;MAX;LAMB2;TCEB1;PDGFRA;PIK3CB;ABL1;TGFBR1;EP300

GNAI1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI1 itself. We selected most functions GNAI1 had, and list some proteins which have the same functions with GNAI1. You can find most of the proteins on our site.

Function Related Protein
G-protein beta/gamma-subunit complex bindingGNAI2B;GNAO1;GNAT2;GNAI2A;PIK3R5;GNAI1;GNA12;GNAT3;GNAO1A
G-protein coupled serotonin receptor bindingGNAO1B;GNAI3;GNAO1A;GNAI1;GNAO1;GNAZ;GNAIA
GDP bindingRAB35;RAB14;PRPS2;PIGC;MIEF1;RAB40C;RAB12;SRP54;RHOA
GTP bindingRRAGCB;DNM1;TUFM;PPP1CA;GNA11A;SEPT8B;RASL11A;RASL12;RAB8B
GTPase activating protein bindingFMNL1;TSC1;TUBB;RGS14;PTBP3;GNAO1;GNAI3;GAPVD1;PIN1
GTPase activityGNAIA;TUBG2;ARL1;SEPT9;EFTUD1;DNM1;RAB5B;ARHGDIB;TUBA8L4
metal ion bindingMUL1B;ZFPM1;BMI1B;ADARB2;IKZF3;PDE9A;ACY1;ZBTB20;SMAD6
protein bindingBLOC1S6;RBBP8;FIG4;LIN7A;IFT27;CAND1;LGALS2;RPTOR;EID3
signal transducer activityOLFR507;MRGPRB8;TACR1B;RGS9;GPR183B;TAS2R140;GNAO1A;GHRHRL;TAAR7D

GNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI1.

NUMA1; GPSM2; RGS17; GPSM3; RGS14; RANGAP1; MT1A; GNG2; Cbx1

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