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HAAO

  • Official Full Name

    3-hydroxyanthranilate 3,4-dioxygenase

  • Overview

    3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
  • Synonyms

    HAAO; 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAAO-4547H Recombinant Human HAAO Protein, GST-tagged Wheat Germ GST
Human HAAO-2403H Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase, His-tagged E.coli His
Human HAAO-13653H Recombinant Human HAAO, GST-tagged E.coli GST 1-286a.a.
Human HAAO-5650HCL Recombinant Human HAAO 293 Cell Lysate HEK293 N/A
Human HAAO-643HFL Recombinant Full Length Human HAAO Protein, C-Flag-tagged Mammalian cells Flag
Human HAAO-5306H Recombinant Human HAAO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HAAO-1038H Recombinant Human HAAO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HAAO-420H Recombinant Human HAAO Protein, His/GST-tagged Insect Cell His/GST Met1-Gly286
Human HAAO-1038H-B Recombinant Human HAAO Protein Pre-coupled Magnetic Beads HEK293
Human HAAO-18H Recombinant Human HAAO Protein, His-tagged E.coli His
Human HAAO-3415HF Recombinant Full Length Human HAAO Protein, GST-tagged In Vitro Cell Free System GST 286 amino acids
Mouse Haao-346M Recombinant Mouse Haao Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HAAO-2778R Recombinant Rat HAAO Protein Mammalian Cell His
Rat HAAO-1128R Recombinant Rat HAAO protein(Met1-Gly286), His-tagged E. coli N-His Met1-Gly286
Rat HAAO-2432R Recombinant Rat HAAO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HAAO-2432R-B Recombinant Rat HAAO Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HAAO-1775Z Recombinant Zebrafish HAAO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAAO Related Articles

HAAO involved in several pathways and played different roles in them. We selected most pathways HAAO participated on our site, such as Tryptophan metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAAO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tryptophan metabolismIL4I1;ASMT;ALDH2.1;AOX3L1;ACAT2;CMTM2A;ABP1;GCDH;HADHA
Metabolic pathwaysGLCEB;CYP26A1;AMY2A2;APIP;IMPDH1A;CEPT1;PNPLA2;CMBL;UGT1A3

HAAO has several biochemical functions, for example, 3-hydroxyanthranilate 3,4-dioxygenase activity, electron carrier activity, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAAO itself. We selected most functions HAAO had, and list some proteins which have the same functions with HAAO. You can find most of the proteins on our site.

Function Related Protein
3-hydroxyanthranilate 3,4-dioxygenase activity
electron carrier activityHSD17B6;NQO2;ACADM;SDHC;NDUFS3;SRD5A1;AOX4;ACOXL;GLRX2
ferrous iron bindingFECH;EGLN2;SNCA;ALKBH3;FXN;UROD;ACP5;ISCA2;FTO
protein bindingEEF1G;SMURF1;NPHP1;RPS6KC1;PGAP2;FOXRED2;GDAP2;PQBP1;PTPN4

HAAO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAAO here. Most of them are supplied by our site. Hope this information will be useful for your research of HAAO.

GAD1; GAD1; POT1; ARHGDIA; TERF2IP

Brkic, H; Kovacevic, B; et al. Human 3-hydroxyanthranilate 3,4-dioxygenase (3HAO) dynamics and reaction, a multilevel computational study. MOLECULAR BIOSYSTEMS 11:898-907(2015).
Seifert, J; et al. Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 116:74-82(2014).
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