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HBEGF

  • Official Full Name

    heparin-binding EGF-like growth factor

  • Overview

    Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.[1] First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87 amino acid glycoprotein which displays highly regulated gene expression.[2] Ectodomain shedding results in the soluble mature form of HB-EGF which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
  • Synonyms

    HBEGF; heparin-binding EGF-like growth factor; diphtheria toxin receptor (heparin binding epidermal growth factor like growth factor) , DTR, DTS, HEGFL; proheparin-binding EGF-like growth factor; Diphtheria toxin receptor (heparin binding EGF like growth factor); heparin binding epidermal growth factor; Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF_HUMAN; HEGFL; Heparin binding EGF like growth factor; Heparin binding epidermal growth factor like growth factor; OTTHUMP00000159876; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HBEGF-8325H Active Recombinant Human HBEGF Sf21 Insect Cell N/A
Human HBEGF-871H Active Recombinant Human HBEGF Insect Cell N/A Met 1-Leu 148
Human HBEGF-4599H Recombinant Human HBEGF Protein, GST-tagged Wheat Germ GST
Human HBEGF-530H Recombinant Human HBEGF protein E.coli N/A 86
Human HBEGF-13682H Recombinant Human HBEGF, GST-tagged E.coli GST 25-162a.a.
Human HBEGF-339H Recombinant Human Heparin-Binding EGF-Like Growth Factor Sf21 Insect Cell N/A
Human HBEGF-256H Recombinant Human heparin-binding EGF-like growth factor, His-tagged E.coli His
Human HBEGF-551HCL Recombinant Human HBEGF cell lysate Insect Cell N/A
Human HBEGF-269H Active Recombinant Human HBEGF Protein CHO
Human HBEGF-1534H Active Recombinant Human HBEGF protein, His-tagged HEK293 His Asp63-Leu148
Human HBEGF-3493HF Recombinant Full Length Human HBEGF Protein, GST-tagged In Vitro Cell Free System GST 208 amino acids
Human HBEGF-3004H Recombinant Human HBEGF Protein (Val21-Thr160), N-His tagged E.coli N-His Val21-Thr160
Human HBEGF-5724H Recombinant Human HBEGF Protein (Leu20-Leu148), C-His tagged Mammalian cells C-His Leu20-Leu148
Human HBEGF-112H Active Recombinant Human HBEGF Protein E.coli
Human HBEGF-2526H Recombinant Human HBEGF Protein (63-148 aa), His-tagged Yeast His 63-148 aa
Human HBEGF-385H Active Recombinant Human HBEGF Protein (86 aa) E.coli 86
Human HBEGF-056H Active Recombinant Human HBEGF Protein E. coli
Human HBEGF-957H Recombinant Human HBEGF Protein, His-tagged HEK293F N-His Val21-Thr160
Mouse Hbegf-564M Recombinant Mouse Hbegf protein E.coli N/A 86
Mouse HBEGF-7506M Recombinant Mouse HBEGF Protein Mammalian Cell His
Mouse Hbegf-7018M Recombinant Mouse Hbegf protein, His & T7-tagged E.coli His/T7 Ser25~Thr160 (Accession # Q06186)
Mouse HBEGF-4076M Recombinant Mouse HBEGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HBEGF-4076M-B Recombinant Mouse HBEGF Protein Pre-coupled Magnetic Beads HEK293
Rat Hbegf-592R Recombinant Rat Hbegf protein E.coli N/A 86
Rat HBEGF-2800R Recombinant Rat HBEGF Protein Mammalian Cell His
Rat HBEGF-2455R-B Recombinant Rat HBEGF Protein Pre-coupled Magnetic Beads HEK293
Rat HBEGF-2455R Recombinant Rat HBEGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rattus norvegicus (Rat) RFL29258RF Recombinant Full Length Rat Proheparin-Binding Egf-Like Growth Factor(Hbegf) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-208)
Rhesus Macaque HBEGF-2043R Recombinant Rhesus monkey HBEGF Protein, His-tagged Mammalian Cell His
Rhesus Macaque HBEGF-1864R Recombinant Rhesus Macaque HBEGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HBEGF-1864R-B Recombinant Rhesus Macaque HBEGF Protein Pre-coupled Magnetic Beads HEK293
Chicken HBEGF-6412C Recombinant Chicken HBEGF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HBEGF Related Articles

HBEGF involved in several pathways and played different roles in them. We selected most pathways HBEGF participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBEGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationSPRED1;FRS2B;CSF2;PSME3;PSMD9;PEA15;EGFR;PEA15A;FGF18B
Adaptive Immune SystemSIGLEC9;CTSC;KIF3B;SIGLEC12;DCTN1;CTSS;AP1M2;CTSB;PIK3AP1
Axon guidanceSRGAP1;DPYSL2;RAC2;CSNK2A1;NFATC4;SPTA1;Plxna2;EFNB1;ROBO1
Bladder cancerFGFR3;E2F3;MMP1A;DAPK2;MMP9;CDKN2A;HRAS;TYMP;RPS6KA5
Constitutive Signaling by Aberrant PI3K in CancerNRG4;KLB;EGF;NRG3;TRAT1;FRS2;HBEGF
Cytokine Signaling in Immune systemSPRED2;GBP2;FGF10B;CRK;HAVCR2;KPNA3;GBP6;WDR83;FRS2A
DAP12 interactionsDAB2IPB;PRKAR1AA;SIRPB1;FGF8B;JAK1;NRG3;SIGLEC15;DUSP10;RASGRP4
DAP12 signalingNRG2A;SPTBN2;FGF8B;JAK3;CNKSR1;AGO2;DAB2IPB;MARK3;DUSP6

HBEGF has several biochemical functions, for example, epidermal growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HBEGF itself. We selected most functions HBEGF had, and list some proteins which have the same functions with HBEGF. You can find most of the proteins on our site.

Function Related Protein
epidermal growth factor receptor bindingTNK2;HBEGFB;AREG;PLSCR1;SNX1;BTC;HBEGFA;ATXN2;VAV3
growth factor activityFGF18;FGF22;MDKA;IL6;FGF8B;KLK1B4;TYMP;THPO;INHBB
heparin bindingRSPO2;THBS2;PRELP;HDGF;CXCL10;ABI3BP;PCSK6;PTCH1;LPL

HBEGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBEGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HBEGF.

S100A4

Kuo, PL; Huang, MS; et al. Lung Cancer-derived Galectin-1 Enhances Tumorigenic Potentiation of Tumor-associated Dendritic Cells by Expressing Heparin-binding EGF-like Growth Factor. JOURNAL OF BIOLOGICAL CHEMISTRY 287:9753-9764(2012).
Belo, A; Cheng, KR; et al. Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 300:G749-G760(2011).
  • Q&As
  • Reviews

Q&As (7)

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How does HBEGF influence cancer cell growth, migration, and invasion? 06/19/2021

HBEGF enhances cancer progression by facilitating tumor cell growth, migration, and invasion.

How does HBEGF interact with its receptors, and what are the downstream signaling pathways involved? 02/19/2021

HBEGF binds to specific receptors, triggering signaling pathways that affect cell growth, survival, and differentiation.

How do changes in HBEGF expression affect skin homeostasis and the development of skin diseases? 08/23/2020

Variations in HBEGF expression impact skin health, influencing processes like repair and the development of skin disorders.

What is the impact of HBEGF in developmental processes, particularly in embryogenesis and organogenesis? 07/24/2019

HBEGF is crucial in embryogenesis and organ development, guiding cell differentiation and organ formation.

What are the mechanisms by which HBEGF modulates cellular responses in inflammation and immune regulation? 05/24/2019

HBEGF modulates inflammation and immune responses, influencing cellular behavior in immune processes.

What role does HBEGF play in cardiovascular diseases, particularly in cardiac hypertrophy and atherosclerosis? 05/18/2019

In cardiovascular diseases, HBEGF is involved in processes like cardiac hypertrophy and atherosclerotic lesion formation.

How does HBEGF contribute to the process of wound healing and tissue regeneration? 03/20/2019

HBEGF promotes wound healing and tissue regeneration by stimulating cell proliferation and migration.

Customer Reviews (3)

Write a review
Reviews
01/14/2019

    Reliable peptide synthesis; accelerates our peptide-based projects.

    10/08/2018

      Efficient protein purification; consistent yields, cost-effective.

      01/30/2018

        Precise protein quantification; ensures data accuracy in our experiments.

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