HBEGF
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Official Full Name
heparin-binding EGF-like growth factor
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Overview
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.[1] First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87 amino acid glycoprotein which displays highly regulated gene expression.[2] Ectodomain shedding results in the soluble mature form of HB-EGF which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions. -
Synonyms
HBEGF; heparin-binding EGF-like growth factor; diphtheria toxin receptor (heparin binding epidermal growth factor like growth factor) , DTR, DTS, HEGFL; proheparin-binding EGF-like growth factor; Diphtheria toxin receptor (heparin binding EGF like growth factor); heparin binding epidermal growth factor; Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF_HUMAN; HEGFL; Heparin binding EGF like growth factor; Heparin binding epidermal growth factor like growth factor; OTTHUMP00000159876; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- CHO
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HBEGF Related Articles
HBEGF involved in several pathways and played different roles in them. We selected most pathways HBEGF participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBEGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARMS-mediated activation | SPRED1;FRS2B;CSF2;PSME3;PSMD9;PEA15;EGFR;PEA15A;FGF18B |
Adaptive Immune System | SIGLEC9;CTSC;KIF3B;SIGLEC12;DCTN1;CTSS;AP1M2;CTSB;PIK3AP1 |
Axon guidance | SRGAP1;DPYSL2;RAC2;CSNK2A1;NFATC4;SPTA1;Plxna2;EFNB1;ROBO1 |
Bladder cancer | FGFR3;E2F3;MMP1A;DAPK2;MMP9;CDKN2A;HRAS;TYMP;RPS6KA5 |
Constitutive Signaling by Aberrant PI3K in Cancer | NRG4;KLB;EGF;NRG3;TRAT1;FRS2;HBEGF |
Cytokine Signaling in Immune system | SPRED2;GBP2;FGF10B;CRK;HAVCR2;KPNA3;GBP6;WDR83;FRS2A |
DAP12 interactions | DAB2IPB;PRKAR1AA;SIRPB1;FGF8B;JAK1;NRG3;SIGLEC15;DUSP10;RASGRP4 |
DAP12 signaling | NRG2A;SPTBN2;FGF8B;JAK3;CNKSR1;AGO2;DAB2IPB;MARK3;DUSP6 |
HBEGF has several biochemical functions, for example, epidermal growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HBEGF itself. We selected most functions HBEGF had, and list some proteins which have the same functions with HBEGF. You can find most of the proteins on our site.
Function | Related Protein |
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epidermal growth factor receptor binding | TNK2;HBEGFB;AREG;PLSCR1;SNX1;BTC;HBEGFA;ATXN2;VAV3 |
growth factor activity | FGF18;FGF22;MDKA;IL6;FGF8B;KLK1B4;TYMP;THPO;INHBB |
heparin binding | RSPO2;THBS2;PRELP;HDGF;CXCL10;ABI3BP;PCSK6;PTCH1;LPL |
HBEGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBEGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HBEGF.
S100A4
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Q&As (7)
Ask a questionHBEGF enhances cancer progression by facilitating tumor cell growth, migration, and invasion.
HBEGF binds to specific receptors, triggering signaling pathways that affect cell growth, survival, and differentiation.
Variations in HBEGF expression impact skin health, influencing processes like repair and the development of skin disorders.
HBEGF is crucial in embryogenesis and organ development, guiding cell differentiation and organ formation.
HBEGF modulates inflammation and immune responses, influencing cellular behavior in immune processes.
In cardiovascular diseases, HBEGF is involved in processes like cardiac hypertrophy and atherosclerotic lesion formation.
HBEGF promotes wound healing and tissue regeneration by stimulating cell proliferation and migration.
Customer Reviews (3)
Write a reviewReliable peptide synthesis; accelerates our peptide-based projects.
Efficient protein purification; consistent yields, cost-effective.
Precise protein quantification; ensures data accuracy in our experiments.
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