HDAC2
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Official Full Name
histone deacetylase 2
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Overview
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] -
Synonyms
HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;
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- C
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- N/A
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- Interacting Protein
- HDAC2 Related Articles
- HDAC2 Related Research Area
- HDAC2 Related Signal Pathway
HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | MCPH1;WEE1;PDS5B;FGFR1OP;RANGAP1B;ATM;TFDP2;CUL1;CEP76 |
Notch signaling pathway | DLC;EP300;PSEN1;HER12;HES1;CTBP1;RBPJA;MIB1;NCOR2 |
Thyroid hormone signaling pathway | PIK3R3;MAP2K2;MED30;PLCG1;AKT1;TP53;PLCG2;RXRB;MED24 |
Huntingtons disease | NDUFA10;GRM5;UQCRQ;COX6B2;NDUFB6;NDUFC2;DNAL1;SLC25A31;SOD2 |
Alcoholism | HRAS;GM6026;HDAC10;HIST1H2BD;HIST1H4H;H3F3C;HIST2H4;HDAC1;GRIN3B |
Epstein-Barr virus infection | TBPL1;PLCG1;POLR2F;PSMD2;ICAM1;XPO1;YWHAG;POLR3F;HLA-F |
Pathways in cancer | LAMB3;TGFB2;IKBKG;PLEKHG5;SOS1;ITGA2B;TRAF1;WNT6;MAPK10 |
Transcriptional misregulation in cancer | SP1;PER2;HIST1H3I;TP53;HMGA2;SPI1;CD86;MAF;SS18 |
Viral carcinogenesis | RBPJ;CREB5;REL;CDK1;HIST3H2BB-PS;GTF2H4;BAD;TRADD;EP300 |
Chronic myeloid leukemia | SMAD3;MAPK1;PIK3CG;STAT5A;PIK3R2;PTPN11;TGFBR2;SOS1;TGFB2 |
HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.
Function | Related Protein |
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NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC7;HDAC10;HDAC11;HDAC3;HDAC6;HDAC9B;HDAC5;HDAC9;HDAC4 |
NF-kappaB binding | COMMD7;RELA;CDK5RAP3;FOXP3;RNF25;MTDH;NFKBIA;COMMD6;CDKN2A |
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | CHD4;MTA2;SMARCA4;RBBP4;GATAD2B;MBD3;SMARCC2;SMARCB1;ACTL6A |
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | ACTB;SMARCC2;HDAC1;MBD3;HDAC2;SMARCE1;CHD4;SMARCC1;MTA2 |
RNA polymerase II repressing transcription factor binding | HDAC2;BBS2;MKKS;BBS4;TCF7L2;PPARA;RBPJ;RBBP8;MTA1 |
chromatin binding | SMAD6;RERE;SOX9;BRD2;WDHD1;CHD8;ARNTL1B;FOSL2;URI1 |
core promoter binding | NONO;PSPC1;ARNTL;MYOG;SPI1;CCAR1;KDM3A;NKX3;CRY1 |
deacetylase activity | SIRT1;HDAC1;AADAC;NDST4;C6orf130;MAPK1IP1L;MACROD2;MACROD1;NDST1 |
enzyme binding | NFKBIA;NOTCH3;HMGA1;PRKCD;DDC;SIRT3;LAMP1;BRCA1;CBX1 |
heat shock protein binding | CDC37;LMAN2;HSPA1L;TOMM34;DNAJB6;DNAJA3B;GRXCR2;DNAJA2;DLST |
histone deacetylase activity | HDAC5;HDAC11;HDAC1;HDAC2;ATXN3L;SIRT1;HDAC8;HDAC7;SIRT2 |
contributes_to nucleosomal DNA binding | MBD3;SMARCA4;SMARCB1;ACTB;HDAC1;SMARCE1;MTA2;ACTL6A;CHD4 |
poly(A) RNA binding | IGF2BP2;RPL7;RPL7L1;FCF1;DDX55;MANF;EIF4E2;PARP1;VCP |
protein binding | CPSF7;ALG2;DNAJC15;CPT1C;COPS7B;FOXRED2;ASH2L;EIF2B5;IRF2 |
protein deacetylase activity | SIRT1;HDAC3;SIRT2;HDAC9;SIN3A;HDAC2;HDAC4;HDAC5;HDAC1 |
sequence-specific DNA binding | LMX1BB;ATF7B;NFIL3-2;PPARGC1A;GATAD2AB;HOXA9;MSXC;SOX7;BATF |
transcription factor binding | TFDP1;SORBS3;ETS1;RNF19A;UBA2;IFI16;RARA;TRIM11;NAB2 |
HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.
HDAC1; SIN3A; MTA1
- Q&As
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Q&As (5)
Ask a questionResearch suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.
Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.
HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.
HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.
HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.
Customer Reviews (3)
Write a reviewIts versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.
This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.
the HDAC2 protein exhibits superior performance across a range of experimental applications.
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