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HDAC2

  • Official Full Name

    histone deacetylase 2

  • Overview

    This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
  • Synonyms

    HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Hi-5 Insect Cell
  • Human
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDAC2-393H Active Recombinant Human HDAC2 protein, His-tagged Insect Cell His
Human HDAC2-28263TH Active Recombinant Human HDAC2, His-tagged Insect Cell His
Human HDAC2-1355H Active Recombinant Human HDAC2, GST-tagged Sf9 Insect Cell GST Full length
Human HDAC2-3565H Recombinant Human HDAC2, His-tagged Hi-5 Insect Cell His
Human HDAC2-13706H Recombinant Human HDAC2, GST-tagged E.coli GST C-term-299a.a.
Human HDAC2-1590H Recombinant Human Histone Deacetylase 2, GST-tagged Sf9 Insect Cell GST
Human HDAC2-1699H Recombinant Human Histone Deacetylase 2, His-tagged Human His
Human HDAC2-93H Recombinant Human HDAC2 Protein, GST-tagged Insect Cell GST 1-488
Human HDAC2-28264TH Recombinant Human HDAC2 Insect Cell N/A 488 amino acids
Human HDAC2-4642H Recombinant Human HDAC2 Protein, His-tagged Insect Cell His
Human HDAC2-5605HCL Recombinant Human HDAC2 293 Cell Lysate HEK293 N/A
Human HDAC2-47H Recombinant Human HDAC2 Protein, His-tagged Insect Cell His
Human HDAC2-13707H Recombinant Human HDAC2 protein, His/GST-tagged E.coli His/GST Met1~Pro488
Human HDAC1-551H Recombinant Human HDAC1 protein, His-tagged E.coli His Met1~Ile428
Human HDAC2-13708H Recombinant Human HDAC2 protein, His-tagged E. coli His Met1~Pro488
Human HDAC212813H Recombinant Human HDAC2 (1-488)-HIS (digested with Trypsin) Protein
Human HDAC2-163H Recombinant Human HDAC2 Protein, His-tagged Insect cell His
Human HDAC2-2985H Recombinant Human HDAC2 Protein (Pro386-Pro488), N-His tagged E.coli N-His Pro386-Pro488
Human HDAC2-2984H Recombinant Human HDAC2 Protein (Full Length), C-Fc tagged Mammalian cells C-Fc Full Length
Human HDAC2-2986H Recombinant Human HDAC2 Protein (386-488), His tagged E.coli His 386-488
Mouse HDAC2-7529M Recombinant Mouse HDAC2 Protein Mammalian Cell His
Mouse Hdac2-1621M Recombinant Mouse Hdac2 Protein, His&GST-tagged E.coli N-His&GST Met1-Pro488
Mouse HDAC2-4090M Recombinant Mouse HDAC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HDAC2-4090M-B Recombinant Mouse HDAC2 Protein Pre-coupled Magnetic Beads HEK293
Rat HDAC2-21R Recombinant Rat HDAC2 protein(Met1~Pro488), His-tagged E.coli N-His Met1~Pro488
Chicken HDAC2-6394C Recombinant Chicken HDAC2 Mammalian Cell His
Kit-1738 HDAC2 Kinetic Assay Kit N/A
Kit-2284 HDAC2 Immunoprecipitation (IP) & Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDAC2 Related Articles
  • HDAC2 Related Research Area
  • HDAC2 Related Signal Pathway

HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleMCPH1;WEE1;PDS5B;FGFR1OP;RANGAP1B;ATM;TFDP2;CUL1;CEP76
Notch signaling pathwayDLC;EP300;PSEN1;HER12;HES1;CTBP1;RBPJA;MIB1;NCOR2
Thyroid hormone signaling pathwayPIK3R3;MAP2K2;MED30;PLCG1;AKT1;TP53;PLCG2;RXRB;MED24
Huntingtons diseaseNDUFA10;GRM5;UQCRQ;COX6B2;NDUFB6;NDUFC2;DNAL1;SLC25A31;SOD2
AlcoholismHRAS;GM6026;HDAC10;HIST1H2BD;HIST1H4H;H3F3C;HIST2H4;HDAC1;GRIN3B
Epstein-Barr virus infectionTBPL1;PLCG1;POLR2F;PSMD2;ICAM1;XPO1;YWHAG;POLR3F;HLA-F
Pathways in cancerLAMB3;TGFB2;IKBKG;PLEKHG5;SOS1;ITGA2B;TRAF1;WNT6;MAPK10
Transcriptional misregulation in cancerSP1;PER2;HIST1H3I;TP53;HMGA2;SPI1;CD86;MAF;SS18
Viral carcinogenesisRBPJ;CREB5;REL;CDK1;HIST3H2BB-PS;GTF2H4;BAD;TRADD;EP300
Chronic myeloid leukemiaSMAD3;MAPK1;PIK3CG;STAT5A;PIK3R2;PTPN11;TGFBR2;SOS1;TGFB2

HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.

Function Related Protein
NAD-dependent histone deacetylase activity (H3-K14 specific)HDAC7;HDAC10;HDAC11;HDAC3;HDAC6;HDAC9B;HDAC5;HDAC9;HDAC4
NF-kappaB bindingCOMMD7;RELA;CDK5RAP3;FOXP3;RNF25;MTDH;NFKBIA;COMMD6;CDKN2A
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA bindingCHD4;MTA2;SMARCA4;RBBP4;GATAD2B;MBD3;SMARCC2;SMARCB1;ACTL6A
contributes_to RNA polymerase II distal enhancer sequence-specific DNA bindingACTB;SMARCC2;HDAC1;MBD3;HDAC2;SMARCE1;CHD4;SMARCC1;MTA2
RNA polymerase II repressing transcription factor bindingHDAC2;BBS2;MKKS;BBS4;TCF7L2;PPARA;RBPJ;RBBP8;MTA1
chromatin bindingSMAD6;RERE;SOX9;BRD2;WDHD1;CHD8;ARNTL1B;FOSL2;URI1
core promoter bindingNONO;PSPC1;ARNTL;MYOG;SPI1;CCAR1;KDM3A;NKX3;CRY1
deacetylase activitySIRT1;HDAC1;AADAC;NDST4;C6orf130;MAPK1IP1L;MACROD2;MACROD1;NDST1
enzyme bindingNFKBIA;NOTCH3;HMGA1;PRKCD;DDC;SIRT3;LAMP1;BRCA1;CBX1
heat shock protein bindingCDC37;LMAN2;HSPA1L;TOMM34;DNAJB6;DNAJA3B;GRXCR2;DNAJA2;DLST
histone deacetylase activityHDAC5;HDAC11;HDAC1;HDAC2;ATXN3L;SIRT1;HDAC8;HDAC7;SIRT2
contributes_to nucleosomal DNA bindingMBD3;SMARCA4;SMARCB1;ACTB;HDAC1;SMARCE1;MTA2;ACTL6A;CHD4
poly(A) RNA bindingIGF2BP2;RPL7;RPL7L1;FCF1;DDX55;MANF;EIF4E2;PARP1;VCP
protein bindingCPSF7;ALG2;DNAJC15;CPT1C;COPS7B;FOXRED2;ASH2L;EIF2B5;IRF2
protein deacetylase activitySIRT1;HDAC3;SIRT2;HDAC9;SIN3A;HDAC2;HDAC4;HDAC5;HDAC1
sequence-specific DNA bindingLMX1BB;ATF7B;NFIL3-2;PPARGC1A;GATAD2AB;HOXA9;MSXC;SOX7;BATF
transcription factor bindingTFDP1;SORBS3;ETS1;RNF19A;UBA2;IFI16;RARA;TRIM11;NAB2

HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.

HDAC1; SIN3A; MTA1

Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can HDAC2 be a potential biomarker for certain diseases? 08/13/2022

Research suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Are there HDAC inhibitors used in clinical settings? 07/16/2022

Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.

How does HDAC2 impact cancer progression? 06/24/2021

HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.

How does HDAC2 influence cellular processes through histone deacetylation? 07/27/2018

HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.

How does HDAC2 relate to neurodegenerative disorders? 10/23/2016

HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.

Customer Reviews (3)

Write a review
Reviews
11/23/2021

    Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

    11/16/2018

      This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.

      08/22/2018

        the HDAC2 protein exhibits superior performance across a range of experimental applications.

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