HDAC4
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Official Full Name
histone deacetylase 4
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Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] -
Synonyms
HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
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- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- Flag
- GST
- GST|His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- HDAC4 Related Articles
- HDAC4 Related Research Area
- HDAC4 Related Signal Pathway
HDAC4 involved in several pathways and played different roles in them. We selected most pathways HDAC4 participated on our site, such as Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alcoholism | GNG5;GRIN3B;HIST2H2AC;GRIN3A;PPP1CB;CALM2;GNG2;SLC18A1;HIST1H2AE |
Epstein-Barr virus infection | EIF2AK3;NFKBIA;SNW1;PIK3R2;PSMC4;TRADD;CD19;SND1;MAP3K7 |
Viral carcinogenesis | PIK3CA;HDAC7;IKBKG;DDX3X;TP53;HIST1H2BL;TRADD;RHOA;HIST1H2BC |
MicroRNAs in cancer | BCL2L2;PDGFRA;EZR;GLS;MTOR;DNMT3A;DDIT4;PRKCE;WNT3 |
HDAC4 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC4 itself. We selected most functions HDAC4 had, and list some proteins which have the same functions with HDAC4. You can find most of the proteins on our site.
Function | Related Protein |
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NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC4;HDAC7;HDAC9;HDAC9B;HDAC11;HDAC2;HDAC1;HDAC8;HDAC6 |
RNA polymerase III transcription factor binding | HDAC5;HDAC4 |
activating transcription factor binding | EEF1D;GATA4;PRDM16;ZFP516;HDAC4;HDAC7A;HDAC1;MEF2D;PSIP1 |
chromatin binding | URI1;RNF168;LHX2;MORF4L1;ZFP932;TFAP2A;NKX2-5;CEBPB;RUNX2 |
core promoter binding | XBP1;EZH2;E2F2;SFPI1;RELB;NEUROG3;E2F1;E2F3;EP300 |
histone deacetylase activity | HDAC8;HDAC6;HDAC2;HDAC9;HDAC10;SIRT1;NACC2;HDAC9B;HDAC4 |
histone deacetylase binding | HDAC6;TFAP4;CBX5;GMNN;NR2E1;USF1;NR2C1;HOXA10;ZMYND15 |
potassium ion binding | PKLR;HDAC4;SLC24A1;PDXK;KCNA4;PKM2;PKMB;SLC24A5;PKMA |
protein binding | MRPL28;HIST1H4C;CFH;ESR2;ZBTB26;TAF1C;LNX2B;NEK2;NF1 |
protein deacetylase activity | SIN3A;HDAC9;HDAC3;SIRT2;HDAC4;SIRT1;HDAC5;HDAC10;HDAC2 |
protein kinase binding | LCK;SLC12A7;ADCY6;TSACC;RB1CC1;RNF138;MAPK8IP2;NME2;BCL2L14 |
repressing transcription factor binding | CTNNB1;TCF3;HDAC4;HDAC1;DDX20;HDAC7A;GMNN;HDAC5;MAGEA2B |
contributes_to sequence-specific DNA binding | SMAD4;NEUROD1;HIF1A;HDAC4;TCF3;PPARG;EPAS1;ARNT;FIGLA |
transcription corepressor activity | SF1;TRIM22;LHX1A;ANKRD1;SAP18;NCOR1;ATN1;IRF2BP2;YY1 |
transcription factor binding | DNMT1;SMARCA4;MED12L;TMEM173;Ar;PSMD10;PSMC5;DIP2C;SMAD3 |
contributes_to transcription regulatory region DNA binding | TAF1;HDAC5;TCF3;NFYA;NFYB;TCF12;HDAC4;NR1H3;ATF4 |
zinc ion binding | RNF222;ZDHHC16B;ALAD;S100A12;GATA5;RNF220;GM757;SHARPIN;TMEM163 |
HDAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC4.
YWHAG; YWHAZ; YWHAE; YWHAH
- Q&As
- Reviews
Q&As (7)
Ask a questionHDAC4 affects cardiac hypertrophy and heart failure by regulating cardiac gene expression.
HDAC4 regulates immune responses and inflammation through gene expression control.
HDAC4 is important for neuronal development and linked to neurodegenerative diseases.
Stress and diet influence HDAC4 activity, affecting its role in gene regulation and cell processes.
Mutations in HDAC4 disrupt skeletal muscle development and contribute to muscular disorders.
HDAC4 controls gene expression by altering histone acetylation, affecting chromatin structure.
HDAC4 interacts with non-histone proteins, influencing various cellular functions.
Customer Reviews (3)
Write a reviewDependable protein-protein interaction assays; integral for our experiments.
Efficient protein purification services; consistent yield and purity.
Expertise in protein engineering; excellent service, highly recommended.
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