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HHAT

Official Full Name

hedgehog acyltransferase
Overview

Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
Synonyms

HHAT; hedgehog acyltransferase; protein-cysteine N-palmitoyltransferase HHAT; FLJ10724; GUP2; MART 2; MART2; rasp; sit; ski; Skn; 2810432O22Rik; AI462858; FLJ34867; AC115917.1; HHAT_HUMAN; MART-2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; OTTHUMP00000034608; OTTHUMP00000034611;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	HHAT-255H	Recombinant Human HHAT Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Mouse	HHAT-7609M	Recombinant Mouse HHAT Protein	Mammalian Cell	His	Inquiry
Mouse	HHAT-4149M	Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Hhat-3389M	Recombinant Mouse Hhat Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	HHAT-4149M-B	Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	HHAT-6488Z	Recombinant Zebrafish HHAT	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
HHAT Related Articles
HHAT Related Research Area

HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis, Signal Transduction, Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog ligand biogenesis	DISP2;OS9;GPC5A;DERL2;NOTUM;HHAT;SCUBE2;NOTUM1A
Signal Transduction	TAGAPB;PENKA;CGNB;SHARPIN;BCO2;DLC1;CCK;FFAR3;WLS
Signaling by Hedgehog	INTU;CDON;SPOP;BOC;GAS8;EFCAB7;HHAT;DZIP1;NOTUM1A

HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity, 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity, 2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

Function	Related Protein
2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity	CML5;LPCAT3;Acnat1;DGAT2L6;MBOAT4;CML2;MBOAT1;HHAT;NAT14
2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity	CML5;MBOAT1;MBOAT7;LPCAT3;ACNAT2;HHAT;Acnat1;CML2;MBOAT4
2-methylhexanoyl-CoA C-acetyltransferase activity	ACNAT2;CML5;LPCAT3;MBOAT4;CML2;Acnat1;HHAT;NAT14;DGAT2L6
3-hydroxybutyryl-CoA thiolase activity	Acnat1;MBOAT1;NAT14;MBOAT7;HHAT;CML5;ACNAT2;CML2;MBOAT4
3-ketopimelyl-CoA thiolase activity	MBOAT4;DGAT2L6;Acnat1;ACNAT2;CML2;NAT14;LPCAT3;MBOAT1;MBOAT7
C-acyltransferase activity	MBOAT4;CML2;MBOAT7;LPCAT3;MBOAT1;DGAT2L6;NAT14;Acnat1;CML5
C-palmitoyltransferase activity	NAT14;Acnat1;ACNAT2;CML5;MBOAT1;MBOAT7;LPCAT3;HHAT;CML2
GTP binding	GBP3;DRG1;RAB43;ARL8B;SAR1B;RAB18B;GEM;RRAGD;RAB38
L-2-aminoadipate N-acetyltransferase activity	NAT14;MBOAT4;LPCAT3;ACNAT2;Acnat1;MBOAT7;MBOAT1;CML2;HHAT
N-acetyltransferase activity	SAT2A;NAA10;NAT6;AANAT1;ACNAT2;SAT1A.1;AANAT2;DGAT2L6;NAT9
N-acyltransferase activity	HHAT;LPCAT3;CML2;DGAT2L6;MBOAT7;MBOAT1;NAT14;HRASLS5;MBOAT4
N-palmitoyltransferase activity	HHAT;DGAT2L6;ACNAT2;Acnat1;CML5;MBOAT4;CML2;MBOAT1;NAT14
N-succinyltransferase activity	MBOAT7;CML5;NAT14;ACNAT2;DGAT2L6;Acnat1;LPCAT3;CML2;MBOAT4
O-acetyltransferase activity	HHAT;Acnat1;NAT14;ACNAT2;CML2;MBOAT4;CML5;MBOAT7;MBOAT1
O-acyltransferase activity	Acnat1;DGAT1B;NAT14;DGAT2L6;CML2;LPCAT3;HHAT;DGAT1A;ACNAT2
O-octanoyltransferase activity	ACNAT2;CML2;MBOAT4;MBOAT1;NAT14;DGAT2L6;HHAT;LPCAT3;MBOAT7
O-palmitoyltransferase activity	Acnat1;DGAT2L6;HHAT;CML5;MBOAT1;ACNAT2;LPCAT3;CML2;MBOAT7
O-sinapoyltransferase activity	MBOAT1;ACNAT2;CML2;NAT14;HHAT;LPCAT3;MBOAT7;MBOAT4;Acnat1
O-succinyltransferase activity	CML5;HHAT;NAT14;LPCAT3;MBOAT1;DGAT2L6;MBOAT4;Acnat1;ACNAT2
Ras palmitoyltransferase activity	MBOAT1;LPCAT3;CML5;Acnat1;MBOAT7;NAT14;CML2;ZDHHC9;HHAT
S-acetyltransferase activity	ACNAT2;CML5;LPCAT3;Acnat1;CML2;MBOAT1;MBOAT4;DGAT2L6;MBOAT7
S-acyltransferase activity	HHAT;CML2;MBOAT1;ACNAT2;NAT14;CML5;MBOAT7;LPCAT3;Acnat1
S-malonyltransferase activity	MBOAT4;MBOAT1;Acnat1;NAT14;LPCAT3;DGAT2L6;HHAT;CML2;CML5
S-succinyltransferase activity	CML5;MBOAT4;CML2;MBOAT1;ACNAT2;HHAT;Acnat1;MBOAT7;LPCAT3
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity	MBOAT4;NAT14;ACNAT2;MBOAT1;DGAT2L6;CML2;CML5;MBOAT7;Acnat1
acetyl-CoA:L-lysine N6-acetyltransferase	Acnat1;MBOAT4;HHAT;CML2;LPCAT3;MBOAT7;DGAT2L6;MBOAT1;CML5
acetyltransferase activity	DGAT2L6;ACNAT2;NAT14;MBOAT4;CREBBP;Acnat1;Nat3;KAT5;CML5
acyl-CoA N-acyltransferase activity	LPCAT3;MBOAT1;DGAT2L6;MBOAT7;CML2;Acnat1;CML5;MBOAT4;NAT14
acylglycerol O-acyltransferase activity	ACNAT2;MBOAT1;LPCAT3;DGAT2L6;NAT14;Acnat1;CML2;MBOAT7;MBOAT4
azetidine-2-carboxylic acid acetyltransferase activity	MBOAT1;ACNAT2;CML5;MBOAT4;Acnat1;NAT14;CML2;HHAT;MBOAT7
benzoyl acetate-CoA thiolase activity	ACNAT2;CML2;DGAT2L6;Acnat1;LPCAT3;HHAT;MBOAT4;CML5;MBOAT7
butyryl-CoA 2-C-propionyltransferase activity	DGAT2L6;MBOAT4;ACNAT2;HHAT;NAT14;CML2;MBOAT7;CML5;MBOAT1
carnitine O-acyltransferase activity	MBOAT1;NAT14;HHAT;Acnat1;CML2;LPCAT3;CML5;MBOAT4;DGAT2L6
dihydrolipoamide S-acyltransferase activity	MBOAT1;ACNAT2;HHAT;MBOAT4;LPCAT3;CML5;NAT14;CML2;MBOAT7
dihydrolipoamide branched chain acyltransferase activity	HHAT;LPCAT3;Acnat1;DGAT2L6;CML2;NAT14;MBOAT7;MBOAT1;MBOAT4
ergosterol O-acyltransferase activity	ACNAT2;CML2;HHAT;DGAT2L6;LPCAT3;NAT14;Acnat1;MBOAT4;MBOAT7
glucosaminyl-phosphotidylinositol O-acyltransferase activity	MBOAT1;ACNAT2;Acnat1;DGAT2L6;NAT14;MBOAT7;CML2;HHAT;LPCAT3
keto acid formate lyase activity	Acnat1;LPCAT3;MBOAT7;HHAT;CML5;NAT14;DGAT2L6;MBOAT1;MBOAT4
lanosterol O-acyltransferase activity	MBOAT7;CML5;ACNAT2;LPCAT3;MBOAT4;DGAT2L6;CML2;MBOAT1;Acnat1
malonyltransferase activity	MBOAT7;HHAT;Acnat1;DGAT2L6;LPCAT3;MBOAT1;MBOAT4;CML2;ACNAT2
myristoyltransferase activity	ACNAT2;MBOAT7;CML5;NAT14;MBOAT4;LPCAT3;CML2;Acnat1;DGAT2L6
naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity	NAT14;MBOAT4;CML5;MBOAT1;Acnat1;DGAT2L6;HHAT;LPCAT3;ACNAT2
nucleotide binding	EEF1A1L2;CSTF2T;TNRC6B;RBM10;RERGLA;RBM4.1;PPRC1;RPS6KAL;CDK12
octanoyltransferase activity	HHAT;CML2;LIPT2;NAT14;Acnat1;MBOAT7;CML5;MBOAT1;LPCAT3
palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity	HHAT;Acnat1;MBOAT7;CML5;MBOAT1;LPCAT3;CML2;MBOAT4;DGAT2L6
palmitoyltransferase activity	ZDHHC3;MBOAT1;ZDHHC14;NAT14;ZDHHC5A;ACNAT2;LPCAT3;ZDHHC20;ZDHHC13
peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	NAA50;MBOAT4;CML5;MBOAT1;MBOAT7;NAT14;HHAT;DGAT2L6;ACNAT2
peptidyl-lysine N6-myristoyltransferase activity	DGAT2L6;HHAT;CML2;MBOAT1;LPCAT3;MBOAT7;NAT14;CML5;Acnat1
peptidyl-lysine N6-palmitoyltransferase activity	Acnat1;NAT14;CML5;LPCAT3;CML2;MBOAT7;HHAT;ACNAT2;MBOAT4
protein-cysteine S-acyltransferase activity	ACNAT2;MBOAT7;DGAT2L6;LPCAT3;MBOAT4;CML2;MBOAT1;CML5;HHAT
protein-cysteine S-myristoyltransferase activity	ACNAT2;CML5;CML2;LPCAT3;MBOAT7;HHAT;NAT14;Acnat1;MBOAT1
serine O-acyltransferase activity	MBOAT1;ACNAT2;NAT14;MBOAT7;DGAT2L6;Acnat1;HHAT;MBOAT4;CML2
sinapoyltransferase activity	CML2;ACNAT2;Acnat1;NAT14;HHAT;CML5;DGAT2L6;LPCAT3;MBOAT4
sterol O-acyltransferase activity	NAT14;ACNAT2;CML5;DGAT2L6;SOAT1;MBOAT7;HHAT;Acnat1;MBOAT4
succinyltransferase activity	ACNAT2;Acnat1;DGAT2L6;LPCAT3;HHAT;NAT14;CML5;MBOAT1;MBOAT4
transferase activity	SULT1ST3;AKT2L;SUV39H1B;UGT5B1;DCLK3;TSSK1;PRDM11;TAB3;UGT1A5
transferase activity, transferring acyl groups	HHATLA;CHAC2;CRATB;MCM3AP;LPGAT1;CML2;MBOAT2;GGT7;DGAT2L6

HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

Tumor Antigens