HLA-B
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Official Full Name
major histocompatibility complex, class I, B
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Overview
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. -
Synonyms
HLA-B; major histocompatibility complex, class I, B; ankylosing spondylitis , AS; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MH;
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- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-B Related Articles
- HLA-B Related Gene Family
HLA-B involved in several pathways and played different roles in them. We selected most pathways HLA-B participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PDCD6IP;CYTH2;ARPC2;MVB12BB;IL2RG;ARFGAP1;PIP5K1C;RAB22A;HSPA1A |
| Phagosome | FCGR2C;HLA-E;DYNC1I2A;SFTPD;ATP6V1B1;FCGR3;PIK3C3;FCGR1;TUBA4A |
| Cell adhesion molecules (CAMs) | LRRC4B;SPN;NLGN4A;SDC4;PTPRC;CLDN7;MAG;Ntng2;NFASC |
| Antigen processing and presentation | HSPA1A;HLA-A;IFNG;HLA-DRA;CANX;CD8A;HSP90AB1;LGMN;CTSS |
| Natural killer cell mediated cytotoxicity | PPP3CA;MICA;ICAM1;IFNGR2;TYROBP;MICB;IFNA5;RAET1E;RAC3 |
| Type I diabetes mellitus | IL12A;FAS;H2-AB1;HLA-DQA1;H2-Q10;HLA-A;HLA-B;H2-AA;PTPRN2 |
| HTLV-I infection | PRKACB;H2-AB1;WNT8A;IKBKB;SLC25A31;FDPS;LTBR;PPP3R1;MAPK8 |
| Herpes simplex infection | STAT1B;STAT2;CYCSB;MAPK10;DAXX;TAF6L;IFNA3;USP7;TLR2 |
| Epstein-Barr virus infection | TRP53;NFKBIE;PIK3R5;TRAF3;HLA-C;CD38;PTMA;PSMC3;NFKB2 |
| Viral carcinogenesis | CREB3L1;HDAC11;GTF2H1;HDAC7A;CCNE1;BAX;EP300;HDAC7;GSN |
| Autoi | CD28;IFNA17;HLA-DRB1;TSHR;Fasl;H2-Q10;CD86;TG;IFNA12 |
| ne thyroid disease | HLA-E;GZMB;IFNA16;CD40;HLA-DQA2;IFNA21;IFNA8;HLA-DOB;HLA-DRB1 |
| Allograft rejection | HLA-B;CD40;H2-AA;HLA-DRB4;H2-AB1;TNF;HLA-DQA2;MICA;HLA-DPA1 |
| Graft-versus-host disease | FAS;HLA-G;HLA-A;H2-AB1;HLA-DRB1;H2-Q10;Il2;HLA-DQB1;KLRD1 |
| Viral myocarditis | HLA-DQA2;CYCS;MYH7;H2-AA;H2-Q10;SGCB;SGCG;ITGB2;FYN |
HLA-B has several biochemical functions, for example, TAP binding, NOT TAP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-B itself. We selected most functions HLA-B had, and list some proteins which have the same functions with HLA-B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP binding | HLA-C;HLA-B;H2-Q10;HLA-A |
| NOT TAP binding | |
| chaperone binding | CDC37;SOD1;DNAJA3A;TP53;AHSA1;DNAJA2;ST13;BAG5;CTSC |
| peptide antigen binding | MHC1ZFA;H2-AB1;TAP1;MHC1UIA;MHC1ZDA;TRGV3;HLA-DPA1;HLA-E;HLA-DQA1 |
| receptor binding | Fgf15;SERPINE2;PVRL3;CAT;TNFSF10;INSL4;PECI;RIPK2;GFRA3 |
HLA-B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-B here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-B.
HLA-C; STAT1; ltp_ebvg; ARHGEF4; GABARAP
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