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HLA-DOA

Official Full Name

major histocompatibility complex, class II, DO alpha
Overview

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
Synonyms

HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA class II histocompatibility antigen, DO alpha chain precursor; HLA DNA; HLA DZA; HLADZ; Lymphocyte antigen; Major histocompatibility complex, class II, DN alpha; MHC class II antigen DOA; MHC DN alpha; MHC DZ alpha; HLA-D0-alpha; MHC DN-alpha; HLA-DNA; HLA-DZA;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DOA-4838H	Recombinant Human HLA-DOA Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DOA-232H	Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged	E.coli	His		Inquiry
Human	HLA-DOA-13814H	Recombinant Human HLA-DOA, GST-tagged	E.coli	GST	25-221a.a.	$319 / 25ug
Human	HLA-DOA-5502HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DOA Related Articles

HLA-DOA involved in several pathways and played different roles in them. We selected most pathways HLA-DOA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	H2-Q10;ATP6V1C2;TAP1;ACTG1;NOX3;HLA-F;TUBB5;THBS4A;MPO
Cell adhesion molecules (CAMs)	CLDNK;CLDN19;CLDN2;ITGAM;NRXN1;CNTNAP2A;CD40;ITGA6B;CLDN11B
Antigen processing and presentation	PSME1;HSPA1L;HLA-C;PSME2;HLA-DQB1;HSPA1A;HLA-DMA;HLA-DPA1;HLA-DOB
Intestinal i	CXCL12;ITGA4;CXCL12A;LTBR;HLA-DRB3;MAP3K14;HLA-DOA;AICDA;CXCR4
ne network for IgA production	CD80;CD86;IL5;IL6;TNFRSF13B;CD28;CXCL12B;ITGA4;ICOS
Type I diabetes mellitus	TNF;HLA-DRB4;ICA1;CD86;GAD1;HLA-B;INS1;HLA-DOB;H2-AA
Leishmaniasis	HLA-DQA1;STAT1;ELK1;HLA-DOB;HLA-DPB1;HLA-DOA;FCGR2A;HLA-DRB3;FCGR3A
Toxoplasmosis	MAPK8;HSPA1A;CD40;HLA-DRB3;HLA-DQA2;BCL2L1;TAB2;TYK2;MAP2K3
Staphylococcus aureus infection	FCGR1A;FCGR1;C5AR1;GM5077;DSG1C;HLA-DOB;CFH;C1QC;CFB
Tuberculosis	HLA-DRB3;HLA-DRB1;ITGAX;MYD88;TGFB1;MAPK10;BCL10;CALM2;MAPK11
Influenza A	STAT1;TNFRSF10D;Ccl12;PIK3R3;TYK2;OAS1;ICAM1;MAPK12;LOC780933
HTLV-I infection	SMAD3;FZD8;GPS2;WNT3;TRP53;IL2RB;Il2;HLA-E;CALR
Herpes simplex infection	SKP2;STAT1B;IFNA5;NXF1;CDC34;HCFC1;HLA-DRB5;HLA-A;HLA-DQA1
Asthma	CD40LG;FCER1G;HLA-DRA;HLA-DOB;HLA-DQA2;HLA-DRB5;CD40;HLA-DRB4;H2-AA
Autoi	IFNA7;CD40;IFNA16;HLA-DPB1;HLA-DQA2;H2-AA;IFNA1;HLA-DOA;IL4
ne thyroid disease	IL4;HLA-DRB3;IFNA2;IFNA5;HLA-DPB1;Ifna15;HLA-DPA1;FAS;IFNA6
Inflammatory bowel disease (IBD)	GATA3;TLR2;RORA;IL5;IL12A;NFKB1;MAF;IL1A;IL6
Systemic lupus erythematosus	HIST1H2AL;C5;HIST1H2AA;H2AFY;SNRPD1;HLA-DRB5;ACTN1;HIST2H3C2;HIST1H4A
Rheumatoid arthritis	CCL2;HLA-DRB5;CCL3L1;CCL3L3;TNFSF11;HLA-DQA2;HLA-DRB1;TNFSF13;ATP6V1G1
Allograft rejection	HLA-DOB;Il2;IFNG;H2-Q10;TNF;HLA-DOA;HLA-DMB;HLA-A;IL4
Graft-versus-host disease	IL6;HLA-DOA;Fasl;HLA-DMB;KLRC1;KIR2DL1;KIR3DL2;HLA-DPA1;HLA-DMA
Viral myocarditis	MYH7;HLA-F;BID;EIF4G3;PRF1;HLA-DOA;H2-Q10;RAC1;RAC3

HLA-DOA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOA itself. We selected most functions HLA-DOA had, and list some proteins which have the same functions with HLA-DOA. You can find most of the proteins on our site.

Function	Related Protein
MHC class II protein complex binding	PKM2;HLA-DMB;HLA-DRA;HLA-DRB1;YWHAE;PKM;HLA-DOA;CD74;HLA-DMA
MHC class II receptor activity	HLA-DRB4;HLA-DPA1;HLA-DOB;KRT17;HLA-DRB3;HLA-DRB1;HLA-DQB1;HLA-DOA;HLA-DQB2
protein binding	RPL11;RPL39L;F10;SMAD2;AKAP12;ZFP346;OCLN;SMIM3;TBL1XR1

HLA-DOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOA.

REL

Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).

Reynolds, RJ; Kelley, JM; et al. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. GENES AND IMMUNITY 11:94-97(2010).

van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).