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HLA-DQB1

Official Full Name

major histocompatibility complex, class II, DQ beta 1
Overview

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
Synonyms

CELIAC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA DQB; HLA DQB1; IDDM1; Lymphocyte antigen; Major histocompatibility complex class II beta; Major histocompatibility complex, class II, DQ beta 1; MHC class II antigen DQB1; MHC class II antigen HLA DQ beta 1; MHC class II DQ beta chain; MHC class II HLA DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; HLA-DQB1; DQw1;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DQB1-27714TH	Recombinant Human HLA-DQB1	Wheat Germ	N/A	89 amino acids	Inquiry
Human	HLA-DQB1-802H	Recombinant Human HLA-DQB1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DQB1-12H	Recombinant Human HLA-DQB1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DQB1-5496HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DQB1-673HF	Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged	In Vitro Cell Free System	GST	261 amino acids	Inquiry
Human	HLA-DQB1-683HF	Recombinant Full Length Human HLA-DQB1 Protein, GST-tagged	In Vitro Cell Free System	GST	261 amino acids	Inquiry
Human	HLA-DQB1-4097H	Recombinant Human HLA-DQB1 protein, His-tagged	E.coli	His	33-227aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein

HLA-DQB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	ATP6V1H;NCF1;ATP6V1B1;THBS1;TLR2;CALR;NOX3;HLA-DMB;ACTG1
Cell adhesion molecules (CAMs)	ESAM;BLB1;CLDN14;Icosl;CD2;CD226;CLDNH;MPZL1L;PRPSAP2
Antigen processing and presentation	CD74;KLRC2;CD8A;HSPA5;HSPA4;PSME1;HLA-DRB1;NFYC;HSPA6
Intestinal i	HLA-DRB1;Icosl;CCR10;CXCR4;CCL27B;LTBR;IL4;CD40LG;MHC2DAB
ne network for IgA production	CCL28;CXCL12B;PIGR;BMA2;CD80;HLA-DOA;HLA-DOB;HLA-DPB1;BLB2
Type I diabetes mellitus	PRF1;HLA-DQA2;HLA-DRB5;HLA-DQB1;HLA-DRB1;GZMB;INS;Il2;IL12A
Leishmaniasis	C3;IFNGR2;FCGR4;TLR2;HLA-DMB;TNF;HLA-DMA;H2-AB1;IL1B
Toxoplasmosis	PIK3CG;ITGA6;MAPK3;LAMB2;TLR2;ITGB1;HLA-DMB;AKT2;PIK3CB
Staphylococcus aureus infection	MASP1;HLA-DPB1;C3AR1;cgr2b;FCGR3A;HLA-DRB5;HLA-DQB1;CFI;C5AR1
Tuberculosis	TLR2;IFNA7;RAB5C;Ifna15;FCGR1;CAMP;ATP6V0A1;HSPA9;ATP6V0A2
Influenza A	MAPK13;AKT2;FDPS;HSPA1L;ADAR;PIK3R2;SLC25A6;IVNS1ABP;Ifna15
HTLV-I infection	WNT4;FZD10;HLA-G;GM-CSF;PDGFRB;HLA-DQB1;FZD7;FZD6;CRTC3
Herpes simplex infection	IL1B;IKBKE;MAPK8A;TNF;IFNA10;IFIH1;CFP;TRAF5;TAF3
Epstein-Barr virus infection	EIF2AK4;TRP53;SPN;MAPK8;PSMC2;PLCG1;LYN;PSMD7;SND1
Asthma	CD40;HLA-DQA1;HLA-DQA2;IL5;HLA-DRB4;PRG2;TNF;IL13;FCER1G
Autoi	HLA-DRB3;IL4;HLA-B;IFNA5;HLA-DQA1;H2-Q10;HLA-G;IFNA6;HLA-DQA2
ne thyroid disease	Il2;IFNA14;HLA-DPB1;HLA-G;Fasl;HLA-DQB1;HLA-DRB5;HLA-B;IFNA2
Inflammatory bowel disease (IBD)	IL21R;IL23;RORC;H2-AB1;HLA-DQA1;HLA-DOA;IL17F;NFATC1;RELA
Systemic lupus erythematosus	HIST1H2AP;H2AFB1;GM14479;HIST1H2BP;H2AFB3;SSB;CD40LG;FCGR1;HIST1H4A
Rheumatoid arthritis	ITGB2L;GM-CSF;ATP6V1D;ATP6V1B2;TGFB3;TNF;HLA-DOA;MMP3;Ctsl
Allograft rejection	HLA-DPA1;HLA-A;CD86;TNF;FASLG;IFNG;HLA-DPB1;CD28;HLA-DRB3
Graft-versus-host disease	CD28;KIR3DL2;FAS;HLA-DQA1;KIR2DL3;HLA-C;HLA-DQA2;KIR2DL1;HLA-DMA
Viral myocarditis	HLA-A;FYN;CD28;HLA-DOA;SGCG;HLA-G;ITGAL;HLA-E;ABL1

HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. We selected most functions HLA-DQB1 had, and list some proteins which have the same functions with HLA-DQB1. You can find most of the proteins on our site.

Function	Related Protein
MHC class II receptor activity	HLA-DRB3;KRT17;HLA-DRA;HLA-DRB1;HLA-DOA;HLA-DQA2;HLA-DOB;HLA-DRB4;HLA-DQA1
peptide antigen binding	HLA-DPA1;H2-Q10;HLA-G;TUBB3;MHC1UXA2;HLA-DRB4;MHC1ZHA;MHC1ZE;TAPBP

HLA-DQB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB1.

HLA-DQA1