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HLA-DRB3

Official Full Name

HLA-DRB3 major histocompatibility complex, class II, DR beta 3 [ Homo sapiens ]
Overview

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Synonyms

major histocompatibility complex, class II, DR beta 3; 4951; MGC117330; DR7; MHC class II antigen DRB3; human leucocyte antigen DRB3; MHC class II HLA-DR beta 3 chain; MHC class II antigen DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA-DR3B;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DRB3-13823H	Recombinant Human HLA-DRB3, His-tagged	E.coli	His	31-228a.a.	$319 / 25ug
Human	HLA-DRB3-1210H	Recombinant Human HLA-DRB3, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DRB3-798HCL	Recombinant Human HLA-DRB3 cell lysate		N/A		Inquiry
Human	HLA-DRB3-234HF	Recombinant Full Length Human HLA-DRB3 Protein, GST-tagged	In Vitro Cell Free System	GST	1 a.a. - 266 a.a.	Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DRB3 Related Articles

HLA-DRB3 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB3 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	HLA-DPB1;ATP6V1B2;ATP6V0E1;ACTB2;HLA-F;TLR4BB;CORO1A;ATP6V0E;ATP6V0B
Cell adhesion molecules (CAMs)	HLA-DRB4;TIGIT;CLDN10;OCLNA;CTLA4;HLA-C;SDC3;CD226;CD58
Antigen processing and presentation	TAPBP;HLA-E;HSPA6;HSPA1L;HLA-DQB1;HLA-DRA;HLA-DRB3;HLA-B;KLRC1
Hematopoietic cell lineage	CD3E;CD2;HLA-DRB1;IL6R;EPOR;FLT3LG;MS4A1;FLT3;ITGAM
Intestinal i	BLB1;HLA-DRB4;MADCAM1;Il2;MHC2A;ICOS;IL15RA;CXCL12;CXCL12A
ne network for IgA production	IL4;HLA-DOA;IL15RA;CCL28;CCL27B;BMA1;MHC2DAB;CXCL12B;MHC2DEB
Type I diabetes mellitus	Il2;HLA-B;HLA-DRB1;PRF1;IL1A;HLA-F;HLA-DOB;HLA-DRB3;IFNG
Leishmaniasis	IL12A;HLA-DPB1;HLA-DRB4;HLA-DQB1;MAPK13;PRKCB;ITGA4;ITGB1;C3
Toxoplasmosis	TYK2;LAMB3;H2-AB1;XIAP;TRAF6;MAPK1;TLR2;BIRC7;LAMC1
Staphylococcus aureus infection	FPR1;HLA-DRB1;HLA-DPA1;FCAR;HLA-DPB1;HLA-DRB4;C1QA;SELPLG;C1QB
Tuberculosis	C3;IFNA16;HLA-DMB;MRC2;FCGR3A;TRAF6;CORO1A;FCER1G;Itgam&Itgb2
Influenza A	EIF2AK2;NXF1;RAE1;SLC25A6;HLA-DPB1;CASP1;OAS1B;NFKB1;CPSF4
HTLV-I infection	WNT9B;SFPI1;ELK1;HLA-A;EGR1;PPP3R2;HLA-DRB1;WNT5A;TLN1
Herpes simplex infection	IL12BA;TAF3;HLA-DMB;TAP2;EIF2AK1;Ccl12;TNFB;MHC2DCB;SFRS3B
Epstein-Barr virus infection	CR2;PSMC6;SND1;CCNA1;TRAF5;MAP2K6;POLR2L;GTF2E2;TYK2
Asthma	CCL11;HLA-DRB5;HLA-DMB;IL5;CD40;IL13;HLA-DOB;EPX;HLA-DOA
Autoi	TPO;HLA-DQB1;H2-AA;HLA-DMA;IL4;Fasl;GZMB;IFNA16;HLA-G
ne thyroid disease	TSHB;IFNA21;Il2;IFNA5;HLA-DQA2;CD40LG;IFNA7;H2-AB1;IL4
Inflammatory bowel disease (IBD)	IFNG;Il4ra;IL6;SMAD3;IL12RB2;IL13;STAT6;IL21;IL2RG
Systemic lupus erythematosus	HIST1H2AP;FCGR1;H2AFB2;H2AFB1;HIST1H3H;HIST1H2AF;HIST1H2BH;HIST1H2AO;HLA-DOB
Rheumatoid arthritis	FLT1;ITGB2L;ATP6AP1;ATP6V1G1;ATP6V0D2;ATP6V0E2;ITGAL;GM-CSF;CCL20
Allograft rejection	IL12B;HLA-G;Fasl;FAS;H2-Q10;GZMB;HLA-DPA1;IL4;MICA
Graft-versus-host disease	HLA-DMB;HLA-DRB1;HLA-G;HLA-DQA2;HLA-DOB;PRF1;HLA-DRB5;HLA-F;HLA-B
Viral myocarditis	H2-AB1;HLA-G;Casp3;CASP8;RAC2;RAC3;SGCG;CD28;ABL1

HLA-DRB3 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB3 itself. We selected most functions HLA-DRB3 had, and list some proteins which have the same functions with HLA-DRB3. You can find most of the proteins on our site.

Function	Related Protein
MHC class II receptor activity	HLA-DOB;HLA-DQB1;HLA-DQA2;HLA-DQA1;HLA-DRA;KRT17;HLA-DRB4;HLA-DRB3;HLA-DOA
peptide antigen binding	HLA-C;AZGP1;MHC1UHA;HLA-A;MHC1UIA;H2-AA;TUBB3;MHC1UBA;CLEC4M
protein binding	EPS8;SSX5;GYPC;CALML3;GNAT1;CD1d1;ACE;SERPINA1A;HIST1H2BB

HLA-DRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB3.

MAP3K13; CDCA8; ZDHHC17

Kosmoliaptsis, V; Gjorgjimajkoska, O; et al. Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. KIDNEY INTERNATIONAL 86:1039-1048(2014).

Baxter-Lowe, LA; Cecka, M; et al. Center-Defined Unacceptable HLA Antigens Facilitate Transplants for Sensitized Patients in a Multi-Center Kidney Exchange Program. AMERICAN JOURNAL OF TRANSPLANTATION 14:1592-1598(2014).