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HLA-DRB4

Official Full Name

major histocompatibility complex, class II, DR beta 4
Overview

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Synonyms

HLA-DRB4; major histocompatibility complex, class II, DR beta 4; HLA DR4B; DR4; DR-4; leukocyte antigen; MHC class2 antigen; MHC HLA DR-beta chain; MHC class II antigen DRB4; DRB1 transplantation antigen; human leucocyte antigen DRB4; MHC class II antigen;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DRB4-1209H	Recombinant Human HLA-DRB4, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DRB4-5492HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DRB4-3738H	Recombinant Human HLA-DRB4 protein, GST-tagged	E.coli	GST	1-266 aa	$319 / 25ug
Human	HLA-DRB4-235HF	Recombinant Full Length Human HLA-DRB4 Protein, GST-tagged	In Vitro Cell Free System	GST	30 a.a. - 266 a.a.	Inquiry
Human	HLA-DRB4-2263H	Recombinant Human HLA-DRB4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DRB4 Related Articles

HLA-DRB4 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB4 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	TAP1;H2-AB1;CLEC7A;SEC22B;PIKFYVE;TUBA2;NOX3;ITGAM;ITGB1B.2
Cell adhesion molecules (CAMs)	CD274;PDCD1;ITGB1;CLDN11;CD40;ITGB1A;HLA-DRB4;HLA-B;NLGN3A
Antigen processing and presentation	HLA-A;TNF;HLA-B;HSPA8;CD8A;HLA-DRB5;HSP90AB1;NFYC;KIR2DL1
Hematopoietic cell lineage	CD5;IL1R2;CD4;TFRC;IL11;CD19;GM13305;CD33;CD24
Intestinal i	HLA-DRA;MHC2DCB;ICOSLG;Icosl;HLA-DPB1;TGFB1A;CD86;TNFRSF17;HLA-DRB3
ne network for IgA production	IL15RA;HLA-DMA;HLA-DRB5;HLA-DQB1;IL-15RA;Il2;IL15;ITGB7;CCR10
Type I diabetes mellitus	INS1;H2-AB1;GAD2;PRF1;CD80;FAS;HLA-DPA1;FASLG;INS
Leishmaniasis	ITGB2L;STAT1;ITGB1;PTPN6;HLA-DRB4;FOS;NFKBIB;MAPK11;NFKB1
Toxoplasmosis	STAT1;TYK2;IKBKG;PIK3CG;TGFB1;HLA-DQA2;LAMA3;CD40LG;HLA-DMA
Staphylococcus aureus infection	FCGR1A;HLA-DQB1;Hc;FPR1;FPR3;FCGR3B;HLA-DRA;FCGR3;HLA-DRB4
Tuberculosis	CD209;CALML3;HLA-DRB1;HLA-DMB;CALM3;HLA-DQA1;IL10RB;LBP;ITGAX
Influenza A	HLA-DMB;MAPK8;AKT1;MAP2K7;OAS1A;IRF7;RELA;TNFRSF10B;IFNGR2
HTLV-I infection	MAPK8;POLD2;KAT2B;FZD5;ANAPC7;HLA-DOA;PRKACB;Fzd4;CANX
Herpes simplex infection	SRSF5A;TTC6;SRSF1B;CASP8;IFNGR2;BMA1;HLA-G;HLA-DMB;SRSF6A
Epstein-Barr virus infection	MAPK12;HSPA1B;HLA-F;TYK2;NUP214;POLR2H;YWHAE;FGR;HDAC2
Asthma	FCER1A;HLA-DMA;TNF;CCL11;HLA-DQB1;IL13;HLA-DRB3;FCER1G;IL3
Autoi	Ifna11;IFNA17;HLA-F;H2-AA;IFNA4;PRF1;IFNA16;HLA-DQA2;HLA-DMA
ne thyroid disease	TSHR;TSHB;H2-Q10;CD40LG;HLA-DQA1;TPO;HLA-G;HLA-DMB;PRF1
Inflammatory bowel disease (IBD)	IL18R1;SMAD2;Il23a;IL18;H2-AB1;HLA-DPA1;IL17F;HLA-DQA2;HLA-DRB1
Systemic lupus erythematosus	GM14482;C2;SSB;HIST2H2BB;HLA-DRB1;SNRPD3;HIST1H2AE;H2AFY;ELANE
Rheumatoid arthritis	CCL3L3;ATP6V1F;ANGPT1;CXCL6;HLA-DPA1;CD86;CD80;IL18;IL17A
Allograft rejection	HLA-G;HLA-DRB1;Fasl;GZMB;HLA-A;HLA-DQA2;HLA-B;H2-AA;HLA-C
Graft-versus-host disease	HLA-DRB1;KIR2DL1;CD86;HLA-DMB;IL6;HLA-DRB3;HLA-DRA;HLA-A;FAS
Viral myocarditis	MYH7;ACTG1;CXADR;HLA-DRB4;CD86;CYCS;CAV1;EIF4G2;RAC1

HLA-DRB4 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB4 itself. We selected most functions HLA-DRB4 had, and list some proteins which have the same functions with HLA-DRB4. You can find most of the proteins on our site.

Function	Related Protein
MHC class II receptor activity	HLA-DQB1;HLA-DQA2;HLA-DOB;HLA-DRB4;HLA-DRB3;HLA-DRB1;HLA-DPA1;HLA-DQB2;HLA-DOA
peptide antigen binding	MAML1;HLA-A;MHC1UFA;MHC1UJA;MHC1ZHA;MHC1ZFA;HLA-DRB4;HLA-G;MHC1UIA
protein binding	S100A1;SLPI;PTPN12;CALR;XRCC2;LGI4;PPP6R2;KIAA1199;SOX15

HLA-DRB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB4.

ASMTL

Rasmussen, S; Donskov, F; et al. Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:487-496(2013).

Resse, M; Paolillo, R; et al. Anti-HLA-A, -B, -DR,-DQB1 and-DQA1 antibodies reactive epitope determination with HLAMatchmaker in multipare awaiting list for heart transplant. HUMAN IMMUNOLOGY 74:937-941(2013).