HLA-F
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Official Full Name
major histocompatibility complex, class I, F
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Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | His | 22-305aa | |
Human | HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | N/A | ||
Human | HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | His | 21-298 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-F Related Articles
- HLA-F Related Gene Family
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | IL2RGA;FAM125A;IST1;TGFBR1A;ARPC5L;DDL-2;EPN1;KITA;ADRBK2 |
Phagosome | Cd209g;OLR1;MRC2;ATP6V1B1;DYNC1I1;CANX;HLA-DQA1;CTSSA;MARCO |
Cell adhesion molecules (CAMs) | SDC2;LRRC4;HLA-DRB4;NLGN2;NRXN1;NRCAMA;LRRC4B;CLDN18;ICAM3 |
Antigen processing and presentation | HLA-DPB1;CTSB;KLRC2;KIR2DS2;CALR;KIR2DS3;HLA-DOA;HSP90AA1;IFI30 |
Type I diabetes mellitus | H2-AB1;TNF;HLA-E;LTA;IL1A;HSPD1;PRF1;HLA-DPB1;HLA-DRB5 |
HTLV-I infection | ETS1;RANBP3;IL1R2;PIK3CG;PIK3R1;FZD8;WNT4;BUB3;MYBL2 |
Herpes simplex infection | HLA-DQB1;IFNA13;PTPN11A;HLA-DRB3;SRSF7A;OAS3;TNFB;FOS;MHC2A |
Epstein-Barr virus infection | YWHAG;TBPL1;POLR2J;MAP2K4;HLA-F;NCOR2;MAP3K7;TRAF6;PSMD11 |
Viral carcinogenesis | STAT5B;HIST1H4H;GRB2;PIK3CA;STAT5A;UBR4;PIK3CB;NRAS;HIST1H2BQ |
Autoi | IFNA1;TSHR;HLA-G;HLA-DMA;HLA-E;HLA-DOA;IFNA7;HLA-F;CD80 |
ne thyroid disease | HLA-E;HLA-C;IFNA2;HLA-DPA1;FAS;HLA-DQB1;IL4;HLA-DQA2;TSHR |
Allograft rejection | H2-AB1;CD80;HLA-DPA1;HLA-DOB;HLA-DMA;CD86;HLA-DQA1;Fasl;HLA-DRA |
Graft-versus-host disease | HLA-F;Fasl;IL6;H2-AB1;HLA-E;H2-AA;HLA-DPA1;IFNG;TNF |
Viral myocarditis | SGCG;CXADR;ITGAL;HLA-DRA;LAMA2;SGCA;ICAM1;ABL2;RAC2 |
HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
Function | Related Protein |
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TAP1 binding | TAPBP;TAP1;TAP2;HLA-F |
TAP2 binding | HLA-F;TAPBP;TAP1 |
peptide antigen binding | H2-AA;HLA-A;H2-AB1;AZGP1;HLA-F;MHC1UDA;MHC1UEA;MR1;TAP1 |
receptor binding | Ar;Ifnl2;ICOSLG;KCNA5;CNPY3;LTB;PCSK1N;CXCL12;CD276 |
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan; ilvD
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