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HLA-F

  • Official Full Name

    major histocompatibility complex, class I, F

  • Overview

    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms

    HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli His 22-305aa
Human HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 N/A
Human HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli His 21-298 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-F Related Articles
  • HLA-F Related Gene Family

HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisIL2RGA;FAM125A;IST1;TGFBR1A;ARPC5L;DDL-2;EPN1;KITA;ADRBK2
PhagosomeCd209g;OLR1;MRC2;ATP6V1B1;DYNC1I1;CANX;HLA-DQA1;CTSSA;MARCO
Cell adhesion molecules (CAMs)SDC2;LRRC4;HLA-DRB4;NLGN2;NRXN1;NRCAMA;LRRC4B;CLDN18;ICAM3
Antigen processing and presentationHLA-DPB1;CTSB;KLRC2;KIR2DS2;CALR;KIR2DS3;HLA-DOA;HSP90AA1;IFI30
Type I diabetes mellitusH2-AB1;TNF;HLA-E;LTA;IL1A;HSPD1;PRF1;HLA-DPB1;HLA-DRB5
HTLV-I infectionETS1;RANBP3;IL1R2;PIK3CG;PIK3R1;FZD8;WNT4;BUB3;MYBL2
Herpes simplex infectionHLA-DQB1;IFNA13;PTPN11A;HLA-DRB3;SRSF7A;OAS3;TNFB;FOS;MHC2A
Epstein-Barr virus infectionYWHAG;TBPL1;POLR2J;MAP2K4;HLA-F;NCOR2;MAP3K7;TRAF6;PSMD11
Viral carcinogenesisSTAT5B;HIST1H4H;GRB2;PIK3CA;STAT5A;UBR4;PIK3CB;NRAS;HIST1H2BQ
AutoiIFNA1;TSHR;HLA-G;HLA-DMA;HLA-E;HLA-DOA;IFNA7;HLA-F;CD80
ne thyroid diseaseHLA-E;HLA-C;IFNA2;HLA-DPA1;FAS;HLA-DQB1;IL4;HLA-DQA2;TSHR
Allograft rejectionH2-AB1;CD80;HLA-DPA1;HLA-DOB;HLA-DMA;CD86;HLA-DQA1;Fasl;HLA-DRA
Graft-versus-host diseaseHLA-F;Fasl;IL6;H2-AB1;HLA-E;H2-AA;HLA-DPA1;IFNG;TNF
Viral myocarditisSGCG;CXADR;ITGAL;HLA-DRA;LAMA2;SGCA;ICAM1;ABL2;RAC2

HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

Function Related Protein
TAP1 bindingTAPBP;TAP1;TAP2;HLA-F
TAP2 bindingHLA-F;TAPBP;TAP1
peptide antigen bindingH2-AA;HLA-A;H2-AB1;AZGP1;HLA-F;MHC1UDA;MHC1UEA;MR1;TAP1
receptor bindingAr;Ifnl2;ICOSLG;KCNA5;CNPY3;LTB;PCSK1N;CXCL12;CD276

HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

q81nr7_bacan; ilvD

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
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