HMGB2
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Official Full Name
high mobility group box 2
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Overview
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. -
Synonyms
HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|Flag|StrepII
- Myc
- DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- HMGB2 Related Articles
HMGB2 involved in several pathways and played different roles in them. We selected most pathways HMGB2 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of DNA fragmentation factor | HIST1H1A;HIST1H1B;HIST1H1C;H1F0;HMGB2;HIST1H1E;DFFA;HMGB2A;HIST1H1D |
Apoptosis | DIABLOB;YWHAQ;CFLAR;DIABLOA;BCL2L1;DAPK1;BID;IRAK1;BCAP31 |
Apoptosis induced DNA fragmentation | HMGB2;HIST1H1C;H1F0;DFFA;HIST1H1A;HIST1H1B;HMGB2A;HIST1H1E;HIST1H1D |
Apoptotic execution phase | H1F0;PLECA;PKP1;CASP8L1;DSP;BCAP31;DSG3;STK24B;STK24 |
Programmed Cell Death | GZME;RNF8;DIABLOA;MLKL;HMGB2A;SATB1;BAXB;STK26;BCAP31 |
RB in Cancer | SMARCA2;DCK;PRMT2;RABIF;HMGB2;ANLN;FAF1;HLTF;RBP1 |
HMGB2 has several biochemical functions, for example, DNA binding, DNA binding, bending, RAGE receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB2 itself. We selected most functions HMGB2 had, and list some proteins which have the same functions with HMGB2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | AHRRB;PRM3;RFX8;ZFP879;KDM5D;ZFP768;PPP1R8;POU4F1;BSX |
DNA binding, bending | TFAM;TOP2A;CRIP1;HHEX;FOXD4;FOXL1;TERF1;HMGA2;TOP2B |
RAGE receptor binding | S100A7;S100A13;FPR1;S100B;S100P;HMGB1;S100A4;S100A12;S100A8 |
chemoattractant activity | VEGFB;SAA4;FGF7;VHL;HMGB1;CCL5;CCL3;VEGFA;SAA1 |
chromatin binding | SKIL;MED1;PYGO2;NCOA1;NR5A1;RUNX2;SMAD4;SOD3;CDCA5 |
damaged DNA binding | RAD52;GTF2H3;DCLRE1C;BRCA1;RAD23B;RPA3;XRCC5;TP53;H2AFX |
double-stranded DNA binding | NKX2-8;CTNNB1;ZNF638;MTERF2;RAD51AP1;CGGBP1;MTERFD3;CSDA;LSM14A |
drug binding | GSTP2;PPARA;CHKA;DHODH;NR1I2;ADH1;CNR1;CHRNA3;NAMPT |
enhancer sequence-specific DNA binding | XBP1;FOXN4;KLF6A;GATA5;TWIST1B;GATA3;TFAP2B;LMO4;SOX11 |
four-way junction DNA binding | MEN1;YY1;HMGB1;HMGB2;RAD51L3;DMC1;HMGB3;RAD51L1;RAD51 |
non-sequence-specific DNA binding, bending | |
poly(A) RNA binding | MEPCE;ZAK;GM5506;KIAA0020;XRCC6;DDX47;FAM98B;RPL4;SUGP2 |
protein binding | SMR3B;ZNF436;ETV4;AP2A1;RGMA;EGLN3;TXNL4B;MED23;ZCCHC12 |
protein domain specific binding | PLAUR;ESRRA;CHMP1A;NCK1;DYNLL1;YWHAG;HOMER3;HIST1H4F;HGS |
single-stranded DNA binding | ERCC1;RPA4;RAD23B;RAD51D;MCM10;PMS1;SUB1;DDX11;CNBP |
supercoiled DNA binding | HMGB1;PSIP1;RPS3;HMGB2 |
transcription factor activity, sequence-specific DNA binding | NKX2-8;GLI3;E4F1;NR1I3;ZNF92;MEOX2;FOSL1A;SMAD5;ZSCAN16 |
transcription factor binding | CRY1;BCOR;HTT;SIRT2;BCL10;SOX17;HDAC1;HYAL1;Ar |
transcription regulatory region DNA binding | KLF11;ZFP821;WNT5A;ZFP335;ATF5;MTERFD1;MLL1;TAL1;Arid4b |
HMGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB2.
PKNOX1; CSNK1A1; 4505953; EIF1B; NFKB1; TRAF6; q81k61_bacan; mdm2_human_probe
- Q&As
- Reviews
Q&As (6)
Ask a questionTherapeutic strategies for HMGB2 include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against HMGB2 to inhibit its aberrant activity in disease, or the regulation of HMGB2 expression through gene knockout or overexpression techniques.
Studies have shown that the aberrant expression of HMGB2 is associated with the occurrence of a variety of diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. In cancer, high expression of HMGB2 is closely related to tumor initiation, development, and metastasis.
Certain biomolecules can serve as molecular markers of HMGB2, such as mRNA or protein of HMGB2 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
At present, some drugs have been developed to act on HMGB2, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of HMGB2 or modulate its expression, thereby treating diseases associated with abnormal expression of HMGB2.
The role of HMGB2 in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.
Detection methods for HMGB2 include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of HMGB2 in tissues or cells to assess its status in the disease.
Customer Reviews (3)
Write a reviewAfter using HMGB2, my experiments are very reproducible, which is convenient for subsequent data analysis and experimental operation.
The structure is stable and not easy to mutate.
HMGB2 has a very high catalytic activity, which can greatly reduce the time and energy required for chemical reactions, and its economic value is immeasurable.
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