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HPX

  • Official Full Name

    hemopexin

  • Overview

    This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress.
  • Synonyms

    HPX; hemopexin; Beta 1B glycoprotein; Beta-1B-glycoprotein; FLJ56652; HEMO; HEMO_HUMAN; HX; OTTHUMP00000164583;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human Plasma
  • Human Serum or Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Rat Serum
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HPX-617H Active Recombinant Human HPX protein, His-tagged HEK293 His Met1-His462
Human HPX-29310H Human Hemopexin Human Plasma N/A
Human HPX-754H Recombinant Human HPX, His tagged Human Cell His
Human HPX-464H Recombinant Human hemopexin, His-tagged E.coli His
Human HPX-4391H Recombinant Human Hemopexin Human N/A
Human HPX-5065H Recombinant Human HPX, His-tagged E.coli His
Human HPX-5021H Recombinant Human HPX Protein, GST-tagged Wheat Germ GST
Human HPX-2789HCL Recombinant Human HPX cell lysate Human Cell N/A
Human HPX-206H Native Human Native Human HPX Human Serum or Plasma N/A 439 amino acids
Human HPX-5484H Recombinant Human HPX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HPX-1889H Recombinant Human HPX Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HPX-2502H Recombinant Human HPX Protein (Thr324-His462), N-His tagged E.coli N-His Thr324-His462
Human HPX-3122H Recombinant Human HPX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HPX-16H Active Human Hemopexin Reference Standard N/A
Human HPX-3639HF Recombinant Full Length Human HPX Protein, GST-tagged In Vitro Cell Free System GST 254 amino acids
Human HPX-207H Native Human Hemopexin Human Plasma N/A
Human HPX-3122H-B Recombinant Human HPX Protein Pre-coupled Magnetic Beads HEK293
Human HPX-29307TH Native Human HPX Human Plasma N/A 439 amino acids
Mouse Hpx-3282M Active Recombinant Mouse Hpx protein, His-tagged HEK293 His Met1-Gln460
Mouse HPX-2279MCL Recombinant Mouse HPX cell lysate Human Cell N/A
Mouse Hpx -40M Mouse Hemopexin Reference Standard N/A
Mouse Hpx-1167M Recombinant Mouse Hpx Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HPX-48M Recombinant Mouse HPX Protein, His-tagged HEK293 His
Rat HPX-2908R Recombinant Rat HPX Protein Mammalian Cell His
Rat Hpx-1142R Recombinant Rat Hpx Protein, His-tagged HEK293 His
Rat Hpx-2066R Recombinant Rat Hpx protein, His-tagged E.coli His Glu31~Thr242 (Accession # P20059)
Rat Hpx-3052R Recombinant Rat Hpx protein, His-tagged E.coli His 24-460aa
Rat HPX-2563R-B Recombinant Rat HPX Protein Pre-coupled Magnetic Beads HEK293
Rat HPX-2563R Recombinant Rat HPX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hpx-5429R Recombinant Rat Hpx protein, His-tagged Yeast His 24-460aa
Rat HPX-84R Native Rat Hemopexin Rat Serum N/A
Rat Hpx-83R Rat Hemopexin Reference Standard N/A
Zebrafish HPX-6221Z Recombinant Zebrafish HPX Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HPX Related Articles
  • HPX Related Research Area

HPX involved in several pathways and played different roles in them. We selected most pathways HPX participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and Uptake of Ligands by Scavenger ReceptorsNFX1;HSPH1;COL1A2;COL3A1;LOC479668;HP;HYOU1;COL1A1;Alb
Scavenging of heme from plasmaCD163;AMBP;HPX;NFX1;HP;LOC479668
Vesicle-mediated transportHYOU1;SNX9B;PPP6R3;GJA4;HPX;COPB2;AP3S1;STAB2;TBC1D8B

HPX has several biochemical functions, for example, heme transporter activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPX itself. We selected most functions HPX had, and list some proteins which have the same functions with HPX. You can find most of the proteins on our site.

Function Related Protein
heme transporter activityFLVCR1;HRG-1;SLC48A1;ABCG2;HPX;SLC48A1A;SLC48A1B;MFSD7B;ABCB7
metal ion bindingZKSCAN1;ZNF404;GUCY1B3;FGD;YY1A;ZBTB44;MLPH;ZNF330;LONRF1L
protein bindingMAGEC2;MPZL2B;COQ7;ALS2;MR1;ZBTB17;SIL1;MYLIPA;TTF2

HPX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPX here. Most of them are supplied by our site. Hope this information will be useful for your research of HPX.

GLUD1; TP63; LTN1; ALB

Iwao, Y; Shiga, K; et al. The need of MMP-2 on the sperm surface for Xenopus fertilization: Its role in a fast electrical block to polyspermy. MECHANISMS OF DEVELOPMENT 134:80-95(2014).
Peng, HY; Jiao, Y; et al. Magnetic quantitative analysis for multiplex glycoprotein with polymer-based elemental tags. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 29:1112-1119(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can HPX be used as a diagnostic marker for hemolytic disorders? 03/08/2022

Yes, low levels of HPX in the blood can be an indicator of hemolytic disorders.

How is HPX involved in managing heme in the body? 10/27/2021

HPX binds to free heme released from hemoglobin, preventing its toxic effects and aiding in its clearance.

How does HPX contribute to the prevention of heme-related toxicity? 04/07/2021

HPX binds to heme, preventing its oxidative and inflammatory damage to tissues and organs.

What clinical conditions are associated with heme release, making HPX relevant? 06/10/2018

Hemolysis, hemoglobinopathies, and various types of anemias can lead to heme release, highlighting the clinical relevance of HPX.

How is HPX regulated in the body, and can its levels be influenced by medications? 12/16/2017

HPX levels can be influenced by various factors, including inflammation and medications like glucocorticoids.

Customer Reviews (3)

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Reviews
12/09/2019

    the manufacturer offers a wide range of HPX protein variants, including recombinant or native forms, as well as different conjugates and modifications.

    02/02/2018

      As a researcher using HPX protein, I have found numerous advantages in its application during trials for various experimental purposes.

      08/15/2017

        the HPX protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.

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